11 Questions
What triggers the release of acetylcholine into the synaptic cleft at the neuromuscular junction?
Arrival of an action potential in the motor neuron
What does acetylcholine bind to on the muscle fiber?
Receptors on the motor end plate
What triggers an action potential along the sarcolemma of a muscle cell?
End-plate potential (EPP) reaching the threshold
Where does the action potential travel along before penetrating into the muscle fiber?
Sarcolemma and T-tubules
What signals the release of calcium ions from the sarcoplasmic reticulum (SR) in a muscle cell?
Action potential in T-tubules
What do calcium ions bind to in a muscle cell?
Troponin, a regulatory protein associated with actin filaments
What causes the exposure of myosin-binding sites on actin filaments?
Binding of calcium to troponin
What provides energy for the myosin heads to pull the actin filaments?
ATP hydrolysis
What leads to the relaxation of the muscle fiber?
Pumping of calcium ions back into the sarcoplasmic reticulum
What binds to the exposed sites on actin, forming cross-bridges?
Myosin heads from the thick filaments
What causes the sarcomere to shorten and the muscle to contract?
Sliding of actin over myosin filaments
Learn about the neuromuscular junction activation and the process of acetylcholine release and binding for muscle contraction.
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