Neuromuscular blockers and spasmolytic drugs

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What is the primary mechanism of action of dantrolene?

Stimulating the release of acetylcholine from the nerve terminals

Blocking the release of intracellular calcium from its storage sites (correct)

Enhancing the activity of muscle relaxant receptors

Inhibiting the action of gamma-aminobutyric acid (GABA) on muscle contractions

Which of the following drugs is used to treat local muscle spasm and acts as a sedative?

Metaxalone

Botulinum toxin

Dantrolene

Cyclobenzaprine (correct)

What is the order of muscle affected by dantrolene?

Smooth muscle, then skeletal muscle

Skeletal muscle only (correct)

Both skeletal and smooth muscle equally

Skeletal muscle, then smooth muscle

Which type of muscle blockage is caused by dantrolene?

Excitation-contraction coupling blockage Signup and view all the answers

What is the half-life of dantrolene?

8-9 hours Signup and view all the answers

Which of the following is NOT a major adverse effect of dantrolene?

Hypertension Signup and view all the answers

What is the effect of calcium ions on muscle contraction?

It triggers the release of muscle contraction Signup and view all the answers

What is the primary mechanism of Carisoprodol's muscle relaxant effect?

By blocking the pain sensations from the nerves Signup and view all the answers

Which of the following is NOT a type of muscle relaxant?

Barbiturates Signup and view all the answers

What is the primary effect of Meprobamate on the CNS?

It depresses the CNS Signup and view all the answers

What is the primary site of action of Baclofen?

Spinal cord Signup and view all the answers

What is the primary mechanism of Mephenesin?

Depressing the CNS Signup and view all the answers

What is the primary mechanism of action of non-depolarizing neuromuscular blockers?

Prevent access of acetylcholine at the motor end plate Signup and view all the answers

Which type of muscle relaxant acts directly on the skeletal muscle?

Directly acting muscle relaxants Signup and view all the answers

What is the order of muscle affected by neuromuscular blockers?

Extraocular, head and neck, then limb muscles Signup and view all the answers

Which of the following drugs is a centrally acting muscle relaxant that acts through GABA A receptors?

Diazepam Signup and view all the answers

What type of neuromuscular blockers act as agonists at acetylcholine receptors?

Depolarizing blockers Signup and view all the answers

Which of the following is an example of a peripheral non-depolarizing neuromuscular blocker?

Pancuronium Signup and view all the answers