Neuromuscular blockers and spasmolytic drugs
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Questions and Answers

What is the primary mechanism of action of dantrolene?

  • Stimulating the release of acetylcholine from the nerve terminals
  • Blocking the release of intracellular calcium from its storage sites (correct)
  • Enhancing the activity of muscle relaxant receptors
  • Inhibiting the action of gamma-aminobutyric acid (GABA) on muscle contractions

    • Which of the following drugs is used to treat local muscle spasm and acts as a sedative?

  • Metaxalone
  • Botulinum toxin
  • Dantrolene
  • Cyclobenzaprine (correct)

    • What is the order of muscle affected by dantrolene?

  • Smooth muscle, then skeletal muscle
  • Skeletal muscle only (correct)
  • Both skeletal and smooth muscle equally
  • Skeletal muscle, then smooth muscle

    • Which type of muscle blockage is caused by dantrolene?

    <p>Excitation-contraction coupling blockage</p> Signup and view all the answers

    What is the half-life of dantrolene?

    <p>8-9 hours</p> Signup and view all the answers

    Which of the following is NOT a major adverse effect of dantrolene?

    <p>Hypertension</p> Signup and view all the answers

    What is the effect of calcium ions on muscle contraction?

    <p>It triggers the release of muscle contraction</p> Signup and view all the answers

    What is the primary mechanism of Carisoprodol's muscle relaxant effect?

    <p>By blocking the pain sensations from the nerves</p> Signup and view all the answers

    Which of the following is NOT a type of muscle relaxant?

    <p>Barbiturates</p> Signup and view all the answers

    What is the primary effect of Meprobamate on the CNS?

    <p>It depresses the CNS</p> Signup and view all the answers

    What is the primary site of action of Baclofen?

    <p>Spinal cord</p> Signup and view all the answers

    What is the primary mechanism of Mephenesin?

    <p>Depressing the CNS</p> Signup and view all the answers

    What is the primary mechanism of action of non-depolarizing neuromuscular blockers?

    <p>Prevent access of acetylcholine at the motor end plate</p> Signup and view all the answers

    Which type of muscle relaxant acts directly on the skeletal muscle?

    <p>Directly acting muscle relaxants</p> Signup and view all the answers

    What is the order of muscle affected by neuromuscular blockers?

    <p>Extraocular, head and neck, then limb muscles</p> Signup and view all the answers

    Which of the following drugs is a centrally acting muscle relaxant that acts through GABA A receptors?

    <p>Diazepam</p> Signup and view all the answers

    What type of neuromuscular blockers act as agonists at acetylcholine receptors?

    <p>Depolarizing blockers</p> Signup and view all the answers

    Which of the following is an example of a peripheral non-depolarizing neuromuscular blocker?

    <p>Pancuronium</p> Signup and view all the answers

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