Neuromuscular blockers and spasmolytic drugs
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Questions and Answers

What is the primary mechanism of action of dantrolene?

  • Stimulating the release of acetylcholine from the nerve terminals
  • Blocking the release of intracellular calcium from its storage sites (correct)
  • Enhancing the activity of muscle relaxant receptors
  • Inhibiting the action of gamma-aminobutyric acid (GABA) on muscle contractions

Which of the following drugs is used to treat local muscle spasm and acts as a sedative?

  • Metaxalone
  • Botulinum toxin
  • Dantrolene
  • Cyclobenzaprine (correct)

What is the order of muscle affected by dantrolene?

  • Smooth muscle, then skeletal muscle
  • Skeletal muscle only (correct)
  • Both skeletal and smooth muscle equally
  • Skeletal muscle, then smooth muscle

Which type of muscle blockage is caused by dantrolene?

<p>Excitation-contraction coupling blockage (A)</p> Signup and view all the answers

What is the half-life of dantrolene?

<p>8-9 hours (B)</p> Signup and view all the answers

Which of the following is NOT a major adverse effect of dantrolene?

<p>Hypertension (D)</p> Signup and view all the answers

What is the effect of calcium ions on muscle contraction?

<p>It triggers the release of muscle contraction (D)</p> Signup and view all the answers

What is the primary mechanism of Carisoprodol's muscle relaxant effect?

<p>By blocking the pain sensations from the nerves (A)</p> Signup and view all the answers

Which of the following is NOT a type of muscle relaxant?

<p>Barbiturates (C)</p> Signup and view all the answers

What is the primary effect of Meprobamate on the CNS?

<p>It depresses the CNS (B)</p> Signup and view all the answers

What is the primary site of action of Baclofen?

<p>Spinal cord (A)</p> Signup and view all the answers

What is the primary mechanism of Mephenesin?

<p>Depressing the CNS (C)</p> Signup and view all the answers

What is the primary mechanism of action of non-depolarizing neuromuscular blockers?

<p>Prevent access of acetylcholine at the motor end plate (D)</p> Signup and view all the answers

Which type of muscle relaxant acts directly on the skeletal muscle?

<p>Directly acting muscle relaxants (A)</p> Signup and view all the answers

What is the order of muscle affected by neuromuscular blockers?

<p>Extraocular, head and neck, then limb muscles (A)</p> Signup and view all the answers

Which of the following drugs is a centrally acting muscle relaxant that acts through GABA A receptors?

<p>Diazepam (C)</p> Signup and view all the answers

What type of neuromuscular blockers act as agonists at acetylcholine receptors?

<p>Depolarizing blockers (B)</p> Signup and view all the answers

Which of the following is an example of a peripheral non-depolarizing neuromuscular blocker?

<p>Pancuronium (A)</p> Signup and view all the answers

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