Muscle Anatomy and Functions

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Questions and Answers

What initiates the contraction of skeletal muscle fibers?

  • Presence of potassium ions
  • Decrease in temperature
  • Stimulus from a motor neuron (correct)
  • Release of myoglobin

What is the process that leads to rigor mortis?

  • Loss of muscle tone
  • Accumulation of calcium in the sarcoplasm (correct)
  • Increased ATP production
  • Enhanced ion pump function

What distinguishes isotonic contraction from isometric contraction?

  • Isotonic contraction occurs only during relaxation
  • Isometric contraction involves sliding filaments
  • Isotonic contraction requires no energy
  • Isotonic contraction changes muscle length while isometric does not (correct)

What is muscle tone?

<p>Normal tension and firmness of a muscle at rest (D)</p> Signup and view all the answers

What occurs during complete tetanus?

<p>Sustained contraction with no relaxation (D)</p> Signup and view all the answers

How does treppe differ from wave summation?

<p>Treppe involves relaxation between stimuli (C)</p> Signup and view all the answers

What is required for muscle relaxation and return to resting length?

<p>Active transport of calcium ions (C)</p> Signup and view all the answers

What characterizes incomplete tetanus?

<p>Muscle fibers relax between contractions (D)</p> Signup and view all the answers

What initiates the muscle contraction process after an action potential reaches the T tubule?

<p>Sarcoplasmic reticulum releases calcium ions (C)</p> Signup and view all the answers

What role do calcium ions play in muscle contraction?

<p>They expose active sites on thin filaments (B)</p> Signup and view all the answers

What process occurs repeatedly during the contraction cycle?

<p>Cross-bridge binding and detachment (B)</p> Signup and view all the answers

What occurs when acetylcholine (ACh) is broken down?

<p>Action potential generation ends (C)</p> Signup and view all the answers

How does the reabsorption of calcium ions affect the muscle fibers?

<p>Decreases calcium concentration in the cytosol (C)</p> Signup and view all the answers

What happens to cross-bridge formation when calcium ions decrease?

<p>Cross-bridge formation ends (B)</p> Signup and view all the answers

What is the final event in the muscle contraction process?

<p>Contraction ends and relaxation occurs (C)</p> Signup and view all the answers

What returns to its normal position after muscle contraction ceases?

<p>Tropomyosin (A)</p> Signup and view all the answers

What is the primary function of skeletal muscles?

<p>Maintain body position (A), Support soft tissues (D)</p> Signup and view all the answers

Which connective tissue layer surrounds the entire muscle?

<p>Epimysium (C)</p> Signup and view all the answers

What is the role of the sarcoplasmic reticulum in muscle contraction?

<p>To store and release calcium ions (D)</p> Signup and view all the answers

What structure is formed by the combination of two terminal cisternae and one T tubule?

<p>Triad (B)</p> Signup and view all the answers

What is NOT a component of a sarcomere?

<p>Transverse tubule (D)</p> Signup and view all the answers

How does acetylcholine (ACh) affect muscle contraction?

<p>Binds to receptors and allows sodium influx (D)</p> Signup and view all the answers

What happens to the H zone during muscle contraction according to the sliding filament theory?

<p>It narrows (B)</p> Signup and view all the answers

Which type of muscle tissue is NOT voluntary?

<p>Both B and C (B)</p> Signup and view all the answers

What is the role of myofilaments in muscle fibers?

<p>Responsible for muscle contraction (C)</p> Signup and view all the answers

Which layer of connective tissue surrounds individual muscle fibers?

<p>Endomysium (C)</p> Signup and view all the answers

What does the sliding filament theory describe?

<p>The interaction of thin and thick filaments during contraction (D)</p> Signup and view all the answers

Which protein is NOT part of thin filaments?

<p>Myosin (A)</p> Signup and view all the answers

What initiates the muscle action potential?

<p>Acetylcholine binding to receptors (C)</p> Signup and view all the answers

What is the predominant role of satellite cells in skeletal muscle?

<p>Repair and regeneration of damaged fibers (A)</p> Signup and view all the answers

Which condition is characterized by continuous muscle contractions due to a toxin from a specific bacteria?

<p>Tetanus (A)</p> Signup and view all the answers

What is the primary energy source generated during anaerobic respiration in muscle fibers?

<p>ATP (B)</p> Signup and view all the answers

During peak muscle exertion, which process do muscles primarily rely on for ATP production?

<p>Glycolysis (C)</p> Signup and view all the answers

What occurs to pyruvic acid during conditions of low oxygen availability in muscles?

<p>It is converted to lactic acid. (D)</p> Signup and view all the answers

What is a significant result of muscle fatigue during prolonged exertion?

<p>Accumulation of lactic acid (C)</p> Signup and view all the answers

What is measured by an electromyogram (EMG)?

<p>Electrical activity of muscle fibers (B)</p> Signup and view all the answers

How much ATP is generated from 1 glucose molecule during anaerobic glycolysis?

<p>2 ATP (B)</p> Signup and view all the answers

What happens to the muscle fibers during the recovery period after exertion?

<p>Mitochondria resume activity. (C)</p> Signup and view all the answers

What is the main consequence of muscle contractions in terms of heat production?

<p>Increased body temperature (B)</p> Signup and view all the answers

During moderate activity, which substrates are primarily utilized for energy?

<p>Glucose and glycogen (A)</p> Signup and view all the answers

What is the relationship between creatine phosphate and ATP in muscle fibers?

<p>Creatine phosphate helps restore ATP levels. (C)</p> Signup and view all the answers

What causes the inability of skeletal muscle to perform required activities?

<p>Lactic acid accumulation (A)</p> Signup and view all the answers

Which of the following is true regarding the Krebs cycle?

<p>It relies on oxygen. (A)</p> Signup and view all the answers

What is the primary effect of growth hormone on skeletal muscles?

<p>Stimulating protein synthesis (C)</p> Signup and view all the answers

Which hormone is responsible for elevating energy consumption in skeletal muscles?

<p>Thyroid hormones (A)</p> Signup and view all the answers

What defines the term 'power' in muscle performance?

<p>Maximum amount of tension produced (B)</p> Signup and view all the answers

How can muscle hypertrophy be achieved?

<p>By engaging in heavy training (A)</p> Signup and view all the answers

What happens to muscles that remain inactive for an extended period?

<p>They may become flaccid (B)</p> Signup and view all the answers

What is a characteristic of cardiac muscle tissue?

<p>Intercalated discs (D)</p> Signup and view all the answers

What is the primary function of intercalated discs in cardiomyocytes?

<p>To maintain structural integrity (B)</p> Signup and view all the answers

Smooth muscle is typically found in which of the following systems?

<p>Digestive and urinary systems (A)</p> Signup and view all the answers

What distinguishes smooth muscle cells from skeletal muscle cells?

<p>Fusiform shape (D)</p> Signup and view all the answers

Which physiological characteristic is NOT present in cardiac tissue?

<p>Tetany (C)</p> Signup and view all the answers

Which component is NOT found in smooth muscle cells?

<p>Sarcomeres (A)</p> Signup and view all the answers

How do electrical signals travel between cardiomyocytes?

<p>Through gap junctions in intercalated discs (A)</p> Signup and view all the answers

What is the primary function of smooth muscle in blood vessels?

<p>Regulating blood flow and pressure (D)</p> Signup and view all the answers

Which type of muscle is characterized by being involuntary and non-striated?

<p>Smooth muscle (A)</p> Signup and view all the answers

Which muscle is NOT part of the rotator cuff?

<p>Teres major muscle (C)</p> Signup and view all the answers

What is the primary function of the gluteus maximus muscle?

<p>Extension and lateral rotation at the hip (B)</p> Signup and view all the answers

Which of the following muscles contributes to the adduction of the thigh?

<p>Pectineus (A)</p> Signup and view all the answers

Which muscles are classified as hip flexors?

<p>Psoas major and iliacus (A)</p> Signup and view all the answers

What is a characteristic of the pelvic girdle?

<p>Is tightly bound to the axial skeleton (D)</p> Signup and view all the answers

Which muscles are primarily responsible for controlling the position of the eye?

<p>Extrinsic eye muscles (C)</p> Signup and view all the answers

Which of the following muscles constricts the mouth opening?

<p>Orbicularis oris (D)</p> Signup and view all the answers

Which nerve supplies the muscles of facial expression?

<p>Facial Nerve (D)</p> Signup and view all the answers

What is the primary function of the masseter muscle?

<p>Lifts the mandible (D)</p> Signup and view all the answers

Which muscles in the eye are supplied by the Oculomotor Nerve, besides the lateral rectus?

<p>Medial rectus and superior rectus (A)</p> Signup and view all the answers

What is the main function of the triceps brachii muscle?

<p>Extension of the elbow (C)</p> Signup and view all the answers

Which of the following muscles is NOT part of the rotator cuff?

<p>Teres major (A)</p> Signup and view all the answers

What is the role of pronator teres and supinator in the forearm?

<p>Rotating the radius (B)</p> Signup and view all the answers

Which muscle primarily flexes and adducts the wrist?

<p>Flexor carpi ulnaris (A)</p> Signup and view all the answers

What condition results from the thickening of the flexor retinaculum?

<p>Carpal tunnel syndrome (D)</p> Signup and view all the answers

Which of the following statements about extrinsic muscles of the hand is true?

<p>Their tendons cross the wrist. (A)</p> Signup and view all the answers

What is the primary role of tendon sheaths in the wrist?

<p>To protect tendons from friction (D)</p> Signup and view all the answers

Which of the following muscles are considered intrinsic muscles of the hand?

<p>Dorsal interossei (D)</p> Signup and view all the answers

Which type of muscle is characterized by fibers that run parallel to the long axis of the muscle?

<p>Parallel muscles (D)</p> Signup and view all the answers

Which of the following describes the arrangement of fascicles in a unipennate muscle?

<p>Fibers arranged on one side of the tendon (A)</p> Signup and view all the answers

What term describes a muscle that opposes the action of the agonist?

<p>Antagonist (D)</p> Signup and view all the answers

Which skeletal muscle type is primarily responsible for opening and closing body openings?

<p>Circular muscles (C)</p> Signup and view all the answers

What is typically the origin of a muscle in relation to its insertion?

<p>The origin is usually proximal to the insertion (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic used in the naming of skeletal muscles?

<p>Historical significance (C)</p> Signup and view all the answers

In a bipennate muscle, the fascicles are arranged in what manner?

<p>Fibers on both sides of the tendon (D)</p> Signup and view all the answers

What is the function of a synergist muscle?

<p>To assist the agonist in performing a movement (B)</p> Signup and view all the answers

Which muscle group primarily consists of the hamstrings responsible for knee flexion?

<p>Flexors of the knee (D)</p> Signup and view all the answers

What is the role of the quadriceps tendon?

<p>Enclose the patella and connect quadriceps to the tibial tuberosity (D)</p> Signup and view all the answers

Which extensor muscle is primarily responsible for plantar flexion of the ankle?

<p>Gastrocnemius (A)</p> Signup and view all the answers

What is the primary action of the popliteus muscle?

<p>Unlocks the knee by rotating the tibia (A)</p> Signup and view all the answers

Which muscle is NOT part of the quadriceps femoris group?

<p>Biceps femoris (A)</p> Signup and view all the answers

What common type of hernia occurs in the abdominal wall?

<p>Umbilical hernia (B)</p> Signup and view all the answers

Which muscle opposes the extensors and is responsible for dorsiflexion?

<p>Tibialis anterior (C)</p> Signup and view all the answers

Which two muscles are commonly considered flexors of the toes?

<p>Flexor digitorum longus and Flexor hallucis longus (B)</p> Signup and view all the answers

As skeletal muscle fibers age, which of the following changes is NOT typically observed?

<p>Increased elasticity (A)</p> Signup and view all the answers

What are the four muscles that comprise the quadriceps femoris?

<p>Vastus medialis, vastus lateralis, rectus femoris, vastus intermedius (A)</p> Signup and view all the answers

Which of the following structures directly holds tendons of the toes as they cross the ankle?

<p>Extensor retinacula (D)</p> Signup and view all the answers

How do skeletal muscles rely on energy during prolonged exertion?

<p>Primarily through anaerobic glycolysis (B)</p> Signup and view all the answers

What is the main role of the iliopsoas muscle group?

<p>Flexion of the hip (A)</p> Signup and view all the answers

What does the term 'agonist' refer to in the context of muscle actions?

<p>The muscle that performs the desired action (B)</p> Signup and view all the answers

What is the primary function of the diaphragm?

<p>Main muscle of respiration (C)</p> Signup and view all the answers

Which muscle is considered the main flexor of the elbow?

<p>Biceps brachii (B)</p> Signup and view all the answers

The fibers of the external oblique muscle run in which direction?

<p>Downward and medially (C)</p> Signup and view all the answers

What role do the rotator cuff muscles primarily serve?

<p>Stabilization of the shoulder joint (D)</p> Signup and view all the answers

What is the primary action of the trapezius muscle?

<p>Stabilizing the scapula (C)</p> Signup and view all the answers

Which muscle primarily assists with lateral rotation at the shoulder?

<p>Infraspinatus (B)</p> Signup and view all the answers

Which group of muscles compresses the underlying structures and rotates the vertebral column?

<p>Oblique muscles (B)</p> Signup and view all the answers

Which statement correctly describes the structure of the rectus abdominis muscle?

<p>Divided transversely by tendinous inscriptions (B)</p> Signup and view all the answers

Which muscle assists the deltoid for the first 15 degrees of abduction?

<p>Supraspinatus (C)</p> Signup and view all the answers

Which muscle is responsible for flexing the vertebral column and opposing the erector spinae muscle?

<p>Rectus abdominis (D)</p> Signup and view all the answers

What is the main action of the serratus anterior muscle?

<p>Protracting and stabilizing the scapula (D)</p> Signup and view all the answers

How do flexor muscles typically position themselves in the arm and forearm?

<p>Anteriorly and medially (C)</p> Signup and view all the answers

Which pelvic floor muscle has a role in controlling the movement of urine through the urethra?

<p>External urethral sphincter (A)</p> Signup and view all the answers

Flashcards

Muscle Tissue Types

Skeletal, cardiac, and smooth muscle tissues make up the muscular system.

Skeletal Muscles

Muscles attached to the skeleton, enabling body movement.

Functions of Skeletal Muscles

Produce movement, maintain posture, support soft tissues, guard openings, and regulate body temperature.

Muscle Fiber

Individual muscle cells, and are very long.

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Sarcomere

The basic contractile unit of a muscle fiber.

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Epimysium

Connective tissue surrounding the entire muscle.

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Perimysium

Connective tissue surrounding muscle fascicles (bundles).

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Endomysium

Connective tissue surrounding individual muscle fibers.

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Neuromuscular Junction (NMJ)

The connection between a nerve ending and a muscle fiber.

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Acetylcholine (ACh)

Neurotransmitter that signals muscle contraction.

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Sliding Filament Theory

Mechanism of muscle contraction where filaments slide past each other.

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Thin Filaments

Filaments composed of actin, tropomyosin, and troponin.

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Myosin

Protein forming thick filaments and for muscle contraction.

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Myofibril

Lengthwise threads within a muscle fiber.

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Transverse (T) Tubules

Deep invaginations of the sarcolemma, which transmit the action potential.

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Muscle Contraction

Shortening of muscle fibers; thin filaments sliding past thick filaments.

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Calcium's Role in Contraction

Calcium release from the SR triggers muscle contraction.

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Isotonic Contraction

Muscle shortens and movement occurs.

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Isometric Contraction

Muscle develops tension but doesn't change length.

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Motor Unit

A single motor neuron and the muscle fibers it controls.

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Muscle Tone

Normal tension and firmness of a muscle at rest.

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Treppe

Increase in muscle tension with successive stimuli.

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Tetany

Sustained muscle contraction without relaxation.

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Action Potential

Electrical signal that travels along a nerve or muscle fiber, triggering a response.

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Sarcoplasmic Reticulum

Specialized endoplasmic reticulum in muscle cells, storing calcium ions.

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Calcium Ions (Ca2+)

Ions crucial for muscle contraction by binding to troponin.

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Cross-Bridge Formation

Myosin heads attaching to actin filaments, initiating the contraction cycle.

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Muscle Contraction Cycle

Repeated process of cross-bridge binding, pivoting, and detaching, fueled by ATP.

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Acetylcholinesterase (AChE)

Enzyme that breaks down acetylcholine, ending the signal.

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Muscle Relaxation

Return of muscle to resting state, involving Ca2+ reuptake and active site recovery.

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T-tubules

Infoldings of the sarcolemma that transmit action potentials into the muscle fiber interior.

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Growth Hormone & Testosterone

These hormones stimulate the synthesis of contractile proteins, leading to muscle growth and enlargement.

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Thyroid Hormones

These hormones increase the rate of energy consumption in both resting and active muscles.

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Epinephrine's Effect on Muscles

Epinephrine enhances the duration and force of muscle contractions, allowing for more powerful and sustained effort.

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Muscle Endurance

The length of time a muscle can sustain a certain activity.

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Factors Affecting Muscle Performance

Muscle performance is influenced by individual physical condition and the types of muscle fibers present.

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Muscle Hypertrophy

An increase in muscle size due to heavy training, resulting in larger muscle fibers, more myofibrils, and increased energy reserves (mitochondria, glycogen).

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Muscle Atrophy

A decrease in muscle size, tone, and power resulting from lack of muscle activity.

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What Happens to Inactive Muscles?

Muscles become flaccid when inactive for days or weeks, and even fibrous tissue may replace muscle fibers with prolonged inactivity.

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Cardiac Muscle

The type of muscle tissue found exclusively in the heart, responsible for pumping blood throughout the body.

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Cardiomyocytes

The specialized cells that make up cardiac muscle tissue, also known as cardiocytes.

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Intercalated Discs

Specialized junctions between cardiomyocytes that maintain structural integrity, enhance communication, and conduct electrical signals.

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Coordination of Cardiomyocytes

Intercalated discs allow cardiomyocytes to act as a single, interconnected unit, ensuring synchronized contraction of the heart.

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Key Physiological Characteristics of Cardiac Tissue

Cardiac muscle exhibits automaticity (self-excitation), conductivity (transmitting signals), excitability (responding to stimuli), and contractility (contraction), but it does NOT experience tetany (sustained contraction).

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Parallel Muscles

Muscle fibers run parallel to the long axis of the muscle, creating a straight, elongated shape. Examples include the sartorius and biceps brachii.

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Convergent Muscles

Muscle fibers converge from a broad origin to a single, narrow tendon, allowing for force in multiple directions. The pectoralis muscles are a good example.

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Circular Muscles

Muscle fibers arranged in a circle and surround openings to control their opening and closing. Examples include the orbicularis oris (lips) and the external anal sphincter.

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Unipennate Muscles

Muscle fibers are arranged on one side of a tendon, increasing force production in a single direction. The extensor digitorum is an example.

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Bipennate Muscles

Muscle fibers attach to a tendon on both sides, providing strong force production in one direction. The rectus femoris is an example.

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Multipennate Muscles

Muscle fibers attach to tendons at multiple points within the muscle, maximizing force generation. A good example is the deltoid muscle.

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Origin

The fixed point of attachment for a muscle. Usually, the origin is proximal (closer to the center of the body) to the insertion.

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Insertion

The moving point of attachment for a muscle. Often, the insertion is distal (further from the center of the body) to the origin.

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Extrinsic Eye Muscles

These six muscles originate on the orbit and insert on the sclera of the eyeball, controlling eye position.

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Muscles of the Tongue

These muscles all end in 'glossus' and are responsible for tongue movement, crucial for speech and swallowing.

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Where do neck muscles group?

Neck muscles are divided into three groups: anterior, posterior, and lateral. They help with head movement, posture, and swallowing.

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Facial Expression Muscles

These muscles are innervated by the Facial Nerve (VII) and control various facial expressions, like smiling, frowning, and blinking.

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What's the strongest jaw muscle?

The Masseter is the strongest jaw muscle, responsible for closing the jaw and chewing.

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Rotator Cuff Muscles

A group of four muscles that surround the shoulder joint, providing stability, movement, and preventing dislocation. They are: Supraspinatus, Infraspinatus, Teres Minor, and Subscapularis.

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Muscles of the Pelvic Girdle

Muscles that connect the pelvic girdle to the lower limb and contribute to movement of the thigh, leg, foot, and toes.

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Gluteal Muscles

Muscles that cover the lateral surface of the ilium and contribute to hip extension, rotation, and abduction.

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Adductors

Muscles that move the thigh towards the midline of the body, responsible for adduction, flexion, and rotation of the thigh.

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Iliopsoas Muscle

A two-in-one muscle that flexes the hip, consisting of the psoas major and iliacus muscles.

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Triceps Brachii

The major extensor muscle of the elbow joint. It originates on the scapula and humerus, has three heads (long, medial, and lateral), and inserts on the olecranon process.

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Pronator Teres

A muscle in the forearm responsible for pronation (turning the palm downwards). It originates on the humerus and ulna and inserts on the radius.

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Supinator

A muscle in the forearm responsible for supination (turning the palm upwards). It originates on the humerus and ulna and inserts on the radius.

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Extrinsic Muscles of the Hand

These muscles are located in the forearm and only their tendons cross the wrist. They control movement of the hand and fingers.

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Intrinsic Muscles of the Hand

Muscles located entirely within the hand. These muscles contribute to fine motor movements and precise hand actions.

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Flexor Carpi Radialis

A muscle that flexes and abducts (moves away from the midline) the wrist joint. It is one of the extrinsic muscles of the hand.

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Extensor Carpi Radialis Longus

A muscle that extends and abducts (moves away from the midline) the wrist joint. It is one of the extrinsic muscles of the hand.

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Extensor Carpi Ulnaris

A muscle that extends and adducts (moves towards the midline) the wrist joint. It is one of the extrinsic muscles of the hand.

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What are Oblique Muscles?

Oblique muscles are found in the abdominal wall and help compress internal structures and rotate the vertebral column.

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What are Rectus Muscles?

Rectus muscles are located in the abdominal wall and contribute to flexing the vertebral column and opposing the erector spinae muscles.

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External Oblique Muscle

The most superficial oblique muscle in the abdomen, fibers run downward and medially.

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Internal Oblique Muscle

Located beneath the external oblique, internal oblique fibers run upward and medially.

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Transversus Abdominis

Deepest abdominal oblique muscle, fibers run horizontally.

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Rectus Abdominis

Located between the xiphoid process and symphysis pubis, separated by linea alba and divided transversely by tendinous inscriptions.

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Diaphragm

Separates the thoracic and abdominal cavities, primary muscle involved in inspiration during breathing.

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Pelvic Floor Muscles

Muscles that support pelvic organs, flex the sacrum and coccyx, and control urine and stool passage.

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Perineum

Area of skin anterior to the anus, extending to vaginal opening (female) or base of testicles (male), rich in nerve endings, site of episiotomy.

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Trapezius

Superficial muscle covering the back and neck, inserting on clavicle and scapular spine.

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Rhomboids & Levator Scapulae

Deep to trapezius, originating on cervical and thoracic vertebrae and inserting on medial scapular border.

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Serratus Anterior

Muscle on the chest, originating along ribs and inserting on anterior scapular margin.

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Pectoralis Major

Muscle between sternum and humerus, adducts and medially rotates the arm, flexes the shoulder.

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Latissimus Dorsi

Muscle between vertebrae and humerus, extends the shoulder, adducts and medially rotates the arm.

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Extensors of the Knee

These muscles straighten the leg at the knee joint, moving the lower leg forward. They originate on the femoral surface and include the powerful quadriceps femoris.

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Flexors of the Knee

These muscles bend the leg at the knee joint, bringing the lower leg backward towards the thigh. They originate on the pelvic girdle and include the hamstring group.

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Quadriceps Femoris

A large group of four muscles located at the front of the thigh; they are the primary extensors of the knee.

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Hamstring Muscles

A group of three muscles located at the back of the thigh; they are the primary flexors of the knee.

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Rectus Femoris

One of the four muscles in the quadriceps group; it is unique for crossing both the hip and knee joint.

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Vasti Muscles

The other three muscles of the quadriceps; they are responsible for extending the knee joint.

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Tibial Tuberosity

A bony prominence on the front of the shinbone (tibia) where the quadriceps tendon attaches.

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Semitendinosus

One of the three hamstring muscles; it is located on the medial (inner) side of the thigh.

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Semimembranosus

One of the three hamstring muscles; it is located on the medial (inner) side of the thigh.

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Biceps Femoris

One of the three hamstring muscles; it is located on the lateral (outer) side of the thigh.

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Plantarflexion

The movement of the foot downwards, pointing your toes away from the shin. This is done by the calf muscles.

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Dorsiflexion

The movement of the foot upwards, pointing your toes towards the shin. This is done by the tibialis anterior muscle.

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Gastrocnemius

A major calf muscle that helps with plantarflexion and knee flexion.

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Soleus

A deep calf muscle that assists with plantarflexion.

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Calcaneal (Achilles) Tendon

A strong tendon that attaches the calf muscles to the heel bone (calcaneus).

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Study Notes

Support & Movement

  • The muscular system is responsible for skeletal movement, maintaining body position, supporting soft tissues, guarding body openings, and maintaining body temperature.

Muscle Tissue

  • Skeletal muscle tissue
  • Cardiac muscle tissue
  • Smooth muscle tissue

Skeletal Muscles

  • Attached to the skeletal system
  • Allow body movement
  • The muscular system only includes skeletal muscles.

Functions of Skeletal Muscles

  • Produce skeletal movement
  • Maintain body position
  • Support soft tissues
  • Guard body openings
  • Maintain body temperature

Structure of Skeletal Muscle

  • Muscle cells (fibers)
  • Connective tissues
  • Blood vessels
  • Lymphatics
  • Nerves

Levels of Organization of Muscle Tissue

  • Level 1: skeletal muscle
  • Level 2: muscle fascicles
  • Level 3: muscle fiber
  • Level 4: myofibril
  • Level 5: sarcomere

Connective Tissue Covering of Skeletal Muscles

  • 3 layers: epimysium, perimysium, endomysium

Epimysium

  • Surrounds the entire muscle
  • Connected to deep fascia
  • Separates muscle from surrounding tissue

Perimysium

  • Surrounds muscle fascicles
  • Contains blood vessels and nerve supply to fascicles

Endomysium

  • Surrounds individual muscle fibers
  • Contains capillaries and nerve fibers
  • Contains satellite (stem) cells for repair

Muscle Attachments

  • Endomysium, perimysium, and epimysium meet together at muscle ends to form connective tissue attachments to bone matrix: tendons (bundles), or aponeuroses (sheets).

Innervations & Blood Supply

  • Skeletal muscles are voluntary muscles, controlled by somatic nerves.
  • Muscles have extensive vascular systems to supply large amounts of oxygen and nutrients, and carry away wastes.

Skeletal Muscle Cells (Fibers)

  • Very long
  • Multinucleated (hundreds of nuclei)
  • Develop through fusion of myoblasts (mesodermal cells).

Structure of Skeletal Muscle Fibers

  • Sacrolemma (= cell membrane)
  • Sarcoplasm (= cytoplasm)
  • Sarcosome (= mitochondrion)
  • Sarcoplasmic reticulum (= SER)
  • Transverse (T) tubule
  • Myofibrils

Sarcolemma

  • Cell membrane of muscle cell
  • Surrounds the sarcoplasm
  • Change in transmembrane potential begins muscle contraction.

Transverse (T) Tubules

  • Deep invaginations of the sarcolemma
  • Run transversely
  • Allow electrical potentials to quickly spread throughout the muscle fibers.

Sarcoplasmic Reticulum (SR)

  • Smooth endoplasmic reticulum (SER)
  • Surrounds each myofibril
  • Forms cisternae; chambers that store Ca2+
  • Releases Ca2+ into sarcomeres to begin muscle contraction.

Triad

  • Formed by 2 terminal cisternae + 1 T tubule
  • Required for excitation-contraction coupling.

Myofibrils

  • Lengthwise threads within muscle fibers
  • Divided into a number of sarcomeres
  • Made up of bundles of proteins (myofilaments).

Myofilaments

  • Part of the cytoskeleton
  • Responsible for muscle contraction
  • Composed of proteins; two types
    • Thin filaments
    • Thick filaments

Thin Filaments

  • 4 proteins: actin, nebulin, tropomyosin, troponin.

Thick Filaments

  • 2 proteins: myosin, titin

Sarcomere

  • Contractile unit of the muscle
  • Structural unit of myofibrils
  • Consists of thin and thick myofilaments
  • Contains alternating dark and light bands (striations).

Lines & Zones

  • A bands: myosin filaments (with actin on both ends)

  • M line: center of the A band

  • I bands: actin filaments only

  • Z line: center of the I bands

  • H zone (band): area around the M line; myosin filaments only

  • Zone of overlap: thick and thin filaments overlap

  • Each sarcomere is composed of one A band in the middle, and ½ of an I band on each side.

Neuromuscular Junction (NMJ)

  • Specialized intercellular connection between: a synaptic terminal of a neuron & motor end plate of a skeletal muscle fiber.

Nerve Action Potential

  • Electrical signal travels along the nerve axon ending at the synaptic terminal,
  • Synaptic terminal releases neurotransmitter acetylcholine (ACh) into the synaptic cleft (gap between synaptic terminal and motor end plate).

Acetylcholine (ACh)

  • Neurotransmitter required for muscle contraction
  • Stored in synaptic vesicles
  • Travels across synaptic cleft
  • Binds to membrane receptors on sarcolemma
  • Causes Na+ to rush into sarcoplasm
  • Initiates muscle action potential
  • Quickly breaks down by acetylcholinesterase (AChE).

Muscle Action Potential

  • Electrical signal generated by sodium influx
  • Travels along the T tubules
  • Leads to excitation-contraction coupling

Excitation-Contraction Coupling

  • Action potential reaches a triad, triggering Ca2+ release from cisternae
  • Requires myosin heads to be loaded by ATP

Muscle Contraction

  • Caused by interactions of thick and thin filaments of sarcomeres
  • Triggered by Ca2+ ions
  • Follows the sliding filament theory

Sliding Filament Theory

  • During muscle contraction, thin filaments slide between thick filaments toward the M line.
  • Z lines move closer, H zone gets narrower, A band does not change, and zone of overlap gets thicker

A Review of Muscle Contraction (Steps 1-10)

  • Steps 1-6: ACh release, Action Potential travels along T tubules, SR release of Ca2+, Active site exposure, Cross-bridge formation, and Contraction cycle begins.
  • Steps 7-10: ACh is broken down, SR reabsorbs Ca2+, Active sites covered, Contraction ends, Muscle returns to resting length

Muscle Fatigue

  • Inability of a skeletal muscle to perform required activities
  • Results
    • Depletion of metabolic reserves
    • Muscle exhaustion from lactic acid accumulation
    • Damage to sarcolemma and sarcoplasmic reticulum

Muscle Metabolism

  • At rest & mild exertion: oxygen is available, ATP generation starts in cytoplasm (glycolysis), and is completed in mitochondria (Krebs cycle - aerobic).
  • At peak exertion: muscles lack oxygen to support mitochondria, muscles rely on glycolysis for ATP, pyruvic acid builds up and is converted to lactic acid, and Sustained condition causes muscle fatigue.

Recovery Period

  • Time required by muscles after exertion to return to normal.
  • Oxygen becomes available
  • Mitochondria resume activity

Muscles & Heat Production

  • Muscle contraction produces heat
  • Up to 70% of muscle energy can be spent as heat, and helps maintain body temperature.
  • Shivering in cold weather helps enhance body heat generation.

Hormones & Muscle Metabolism

  • Growth hormone and testosterone stimulate synthesis of contractile proteins and enlargement of skeletal muscles.
  • Thyroid hormones elevate rate of energy consumption in resting and active skeletal muscles.
  • Epinephrine increases duration and force of contraction

Muscle Performance

  • Power: maximal amount of tension produced.
  • Endurance: amount of time an activity can be sustained.
  • Power and endurance depend physical condition and types of muscle fibers.

Types of Skeletal Muscle Fibers

  • Properties of fast fibers
  • Properties of slow fibers
  • Properties of intermediate fibers

Muscle Hypertrophy & Atrophy

  • Hypertrophy: increases in diameter and number of myofibrils of muscle fibers; due to heavy training.
  • Atrophy: due to lack of muscle activity; reduces muscle size, tone, and power

Use it or lose it!

  • Muscle tone indicates base activity in motor units of skeletal muscles.
  • Muscles become flaccid when inactive for days or weeks.
  • With prolonged inactivity, fibrous tissue may replace muscle fibers
  • What you don't use, you lose.

Cardiac Muscle

  • ONLY in the heart
  • Contains cardiac muscle fibers (cardiomyocytes = cardiocytes)

Characteristics of Cardiomyocytes

  • Short – branched
  • Involuntary
  • Mononucleated
  • Striated
  • Short and wide T tubules
  • SR has no terminal cisternae
  • No triads
  • Aerobic (high in myoglobin, mitochondria)
  • Have intercalated discs

Intercalated Discs

  • Specialized contact points between cardiomyocytes; join cell membranes (gap junctions, desmosomes) and branching sites.
  • Functions
    • Maintain structure
    • Enhance molecular and electrical connections
    • Conduct action potentials

Coordination of Cardiomyocytes

  • Intercalated discs connect cardiomyocytes mechanically, chemically, and electrically, causing the heart to work like a single fused mass of cells.

Physiological Characteristics of Cardiac Tissue

  • Automaticity; SA node
  • Contractibility
  • Conductivity
  • Excitability; no tetany

Smooth Muscles

  • Fusiform shaped
  • Involuntary
  • Mononucleated
  • Nonstriated
  • Controlled by pacesetter cells
  • No tendons, or aponeuroses
  • No T tubules
  • No sarcomeres: scattered myofilaments, thin filaments attached to dense bodies
  • Dense bodies; transmit contractions between cells

Comparing Skeletal, Cardiac, & Smooth Muscle Tissues

  • Properties of skeletal, cardiac, and smooth muscles

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