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Questions and Answers
What regions of the antibody molecule are responsible for facilitating interaction with antigens?
What regions of the antibody molecule are responsible for facilitating interaction with antigens?
- CH2 and VH
- CDR1 and CDR3
- Hinge region
- CH1 and CL domains (correct)
Which antibody chains contain an extended sequence with no homology with other domains, called the hinge region?
Which antibody chains contain an extended sequence with no homology with other domains, called the hinge region?
- β and γ heavy chains
- γ, δ and α heavy chains (correct)
- κ and λ light chains
- β and ε heavy chains
What component of the antibody molecule contributes to increasing the maximum rotation of the Fab arms?
What component of the antibody molecule contributes to increasing the maximum rotation of the Fab arms?
- CH1 and CL domains (correct)
- CH2 and CH3 domains
- CDR1 and CDR3
- VH and VL interactions
Which part of the heavy chain is rich in proline residues and provides segmental flexibility to IgG, IgD, and IgA?
Which part of the heavy chain is rich in proline residues and provides segmental flexibility to IgG, IgD, and IgA?
What part of the antibody molecule has conformational changes that can move 2.7Ã…?
What part of the antibody molecule has conformational changes that can move 2.7Ã…?
What is the difference between immunogenicity and antigenicity?
What is the difference between immunogenicity and antigenicity?
What are epitopes?
What are epitopes?
What family do antibodies belong to?
What family do antibodies belong to?
What are haptens?
What are haptens?
Which scientist worked on the recognition of haptens by antibodies?
Which scientist worked on the recognition of haptens by antibodies?
What happens when haptens are modified in the para position with nonionic derivatives according to Karl Landsteiner's work?
What happens when haptens are modified in the para position with nonionic derivatives according to Karl Landsteiner's work?
What is the role of oligosaccharide side chains in antibody molecules?
What is the role of oligosaccharide side chains in antibody molecules?
Which domain of IgG, IgD, and IgA is separated by oligosaccharide side chains?
Which domain of IgG, IgD, and IgA is separated by oligosaccharide side chains?
What is the composition of the carboxy-terminal domain in secreted immunoglobulins (sIg)?
What is the composition of the carboxy-terminal domain in secreted immunoglobulins (sIg)?
Which type of B cell expresses mIgM and mIgD before antigen activation?
Which type of B cell expresses mIgM and mIgD before antigen activation?
What promotes opsonization in the immune response?
What promotes opsonization in the immune response?
How do the hinge-like features contribute to the function of μ and ε chains in antibodies?
How do the hinge-like features contribute to the function of μ and ε chains in antibodies?
Which type of molecular size is considered an active immunogen?
Which type of molecular size is considered an active immunogen?
What is the effect of adjuvants when mixed with an antigen?
What is the effect of adjuvants when mixed with an antigen?
Which type of antigen presentation route is commonly used for boosters?
Which type of antigen presentation route is commonly used for boosters?
What is the role of the genotype of the recipient animal in immunogenicity?
What is the role of the genotype of the recipient animal in immunogenicity?
Which type of antigens can induce B cell responses when appropriately presented?
Which type of antigens can induce B cell responses when appropriately presented?
What is the main function of Freund's incomplete adjuvant?
What is the main function of Freund's incomplete adjuvant?
What is the characteristic composition of B cell epitopes on native proteins?
What is the characteristic composition of B cell epitopes on native proteins?
Which type of epitopes in glucagon elicited an antibody response in mice?
Which type of epitopes in glucagon elicited an antibody response in mice?
How do B cell epitopes on protein antigens differ from T cell epitopes?
How do B cell epitopes on protein antigens differ from T cell epitopes?
What was the outcome of the experiment conducted by A Tiselius and E Kabat in 1939?
What was the outcome of the experiment conducted by A Tiselius and E Kabat in 1939?
What type of cells are often found at the site of adjuvant injection?
What type of cells are often found at the site of adjuvant injection?
Which part of a protein is usually recognized by B cell epitopes?
Which part of a protein is usually recognized by B cell epitopes?
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