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Questions and Answers
What is a key feature of malignant plasma cells in multiple myeloma?
What is a key feature of malignant plasma cells in multiple myeloma?
- They produce excessive amounts of antibodies.
- They differentiate into mature B cells.
- They have specific adhesion molecules for bone marrow stromal cells. (correct)
- They undergo rapid apoptosis.
Which cytokine is produced by stromal cells in the bone marrow that aids in multiple myeloma pathogenesis?
Which cytokine is produced by stromal cells in the bone marrow that aids in multiple myeloma pathogenesis?
- Interleukin-2 (IL-2)
- Interferon-gamma (IFN-γ)
- Tumor necrosis factor-alpha (TNF-α)
- Interleukin-6 (IL-6) (correct)
What role does interleukin-6 (IL-6) play in the growth of malignant plasma cells?
What role does interleukin-6 (IL-6) play in the growth of malignant plasma cells?
- It inhibits bone marrow function.
- It stimulates growth and prevents apoptosis. (correct)
- It promotes the secretion of antibodies.
- It induces differentiation into B cells.
What effect does interleukin-6 (IL-6) have on osteoclast activity?
What effect does interleukin-6 (IL-6) have on osteoclast activity?
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What is a critical event in the transformation to malignant plasma cells in multiple myeloma?
What is a critical event in the transformation to malignant plasma cells in multiple myeloma?
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Study Notes
Multiple Myeloma Pathogenesis
- Multiple myeloma develops through multiple mutations in the DNA of plasma cells, leading to malignant transformation
- Malignant plasma cells express adhesion molecules enabling them to attach to the stromal cells within the bone marrow
- Stromal cells in the bone marrow produce interleukin-6 (IL-6)
- IL-6 acts as a growth factor for plasma cells, protecting them from programmed cell death (apoptosis), and encouraging the formation of osteoclasts, which degrade bone tissue
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