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5 Questions

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Multiple Myeloma Pathogenesis

Created by

@ComfortableConnemara8040

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Questions and Answers

What is a key feature of malignant plasma cells in multiple myeloma?

They produce excessive amounts of antibodies.

They differentiate into mature B cells.

They have specific adhesion molecules for bone marrow stromal cells. (correct)

They undergo rapid apoptosis.

Which cytokine is produced by stromal cells in the bone marrow that aids in multiple myeloma pathogenesis?

Interleukin-2 (IL-2)

Interferon-gamma (IFN-γ)

Tumor necrosis factor-alpha (TNF-α)

Interleukin-6 (IL-6) (correct)

What role does interleukin-6 (IL-6) play in the growth of malignant plasma cells?

It inhibits bone marrow function.

It stimulates growth and prevents apoptosis. (correct)

It promotes the secretion of antibodies.

It induces differentiation into B cells.

What effect does interleukin-6 (IL-6) have on osteoclast activity?

<p>It stimulates osteoclast activity.</p> Signup and view all the answers

What is a critical event in the transformation to malignant plasma cells in multiple myeloma?

<p>Multiple mutational events.</p> Signup and view all the answers

Study Notes

Multiple Myeloma Pathogenesis

Multiple myeloma develops through multiple mutations in the DNA of plasma cells, leading to malignant transformation
Malignant plasma cells express adhesion molecules enabling them to attach to the stromal cells within the bone marrow
Stromal cells in the bone marrow produce interleukin-6 (IL-6)
IL-6 acts as a growth factor for plasma cells, protecting them from programmed cell death (apoptosis), and encouraging the formation of osteoclasts, which degrade bone tissue

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Description

Explore the intricate process of multiple myeloma development through genetic mutations in plasma cells. This quiz covers the role of adhesion molecules and interleukin-6 (IL-6) in maintaining malignant plasma cells and their interaction with bone marrow stromal cells. Test your knowledge of how these factors contribute to the disease's progression.