Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

5 Questions

3 Views

Multiple Myeloma Pathogenesis

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a key feature of malignant plasma cells in multiple myeloma?

They produce excessive amounts of antibodies.

They differentiate into mature B cells.

They have specific adhesion molecules for bone marrow stromal cells. (correct)

They undergo rapid apoptosis.

Which cytokine is produced by stromal cells in the bone marrow that aids in multiple myeloma pathogenesis?

Interleukin-2 (IL-2)

Interferon-gamma (IFN-γ)

Tumor necrosis factor-alpha (TNF-α)

Interleukin-6 (IL-6) (correct)

What role does interleukin-6 (IL-6) play in the growth of malignant plasma cells?

It inhibits bone marrow function.

It stimulates growth and prevents apoptosis. (correct)

It promotes the secretion of antibodies.

It induces differentiation into B cells.

What effect does interleukin-6 (IL-6) have on osteoclast activity?

<p>It stimulates osteoclast activity.</p> Signup and view all the answers

What is a critical event in the transformation to malignant plasma cells in multiple myeloma?

<p>Multiple mutational events.</p> Signup and view all the answers

Study Notes

Multiple Myeloma Pathogenesis

Multiple myeloma develops through multiple mutations in the DNA of plasma cells, leading to malignant transformation
Malignant plasma cells express adhesion molecules enabling them to attach to the stromal cells within the bone marrow
Stromal cells in the bone marrow produce interleukin-6 (IL-6)
IL-6 acts as a growth factor for plasma cells, protecting them from programmed cell death (apoptosis), and encouraging the formation of osteoclasts, which degrade bone tissue

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Explore the intricate process of multiple myeloma development through genetic mutations in plasma cells. This quiz covers the role of adhesion molecules and interleukin-6 (IL-6) in maintaining malignant plasma cells and their interaction with bone marrow stromal cells. Test your knowledge of how these factors contribute to the disease's progression.