Multiple Gestation and Twin Classification
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Questions and Answers

What is the definition of twin pregnancy?

Twin pregnancy is defined as the presence of two fetuses in a single pregnancy, occurring in about 1-2% of all pregnancies.

What are the primary classifications of twins?

Twins can be classified as monozygotic or dizygotic, and further categorized by their chorionicity (number of placentas) and amnionicity (number of amniotic sacs).

Identify two risk factors associated with dizygotic twin pregnancies.

Risk factors for dizygotic twins include maternal age (increased likelihood after age 35) and family history of twins.

What is one major complication associated with twin pregnancies?

<p>One major complication of twin pregnancies is preterm birth, which can lead to increased neonatal morbidity.</p> Signup and view all the answers

What methods can be used to diagnose a twin pregnancy?

<p>A twin pregnancy can be diagnosed using ultrasound imaging and measuring the fundal height.</p> Signup and view all the answers

How can multiple births be classified based on the number of fertilized eggs?

<p>Multiple births can be classified into two categories: monozygotic, derived from one fertilized egg, and dizygotic, arising from two distinct fertilized eggs.</p> Signup and view all the answers

Describe the planning considerations for delivery in twin pregnancies.

<p>Delivery planning for twin pregnancies involves assessing the presentation of the fetuses and the potential for cesarean delivery based on complications.</p> Signup and view all the answers

What is the difference between monochorionic and dichorionic twins?

<p>Monochorionic twins share a single placenta, while dichorionic twins each have their own placenta.</p> Signup and view all the answers

What is the main difference between monozygotic and dizygotic twins?

<p>Monozygotic twins develop from a single fertilized ovum that splits, making them genetically identical, while dizygotic twins arise from two separate ova fertilized by two separate sperm, making them genetically different.</p> Signup and view all the answers

What type of twin pregnancy results from the zygote splitting within three days of fertilization?

<p>This results in dichorionic diamniotic twins.</p> Signup and view all the answers

What outcomes arise from monozygotic twins splitting after the 12th day of fertilization?

<p>Splitting after the 12th day results in conjoined twins.</p> Signup and view all the answers

Describe the characteristics of monochorionic diamniotic twins.

<p>Monochorionic diamniotic twins occur when the zygote divides between days four and eight post-fertilization, having one placenta and two amniotic cavities.</p> Signup and view all the answers

How do dizygotic twins typically develop in terms of placentation and amniotic cavities?

<p>Dizygotic twins typically develop as dichorionic diamniotic twins, meaning each twin has its own placenta and amniotic cavity.</p> Signup and view all the answers

What percentage of twin pregnancies are monozygotic compared to dizygotic?

<p>Around 30% of twin pregnancies are monozygotic, while 70% are dizygotic.</p> Signup and view all the answers

What occurs if embryonic splitting happens after the 9th day following fertilization?

<p>If splitting occurs after the 9th day, it results in monoamniotic monochorionic twins.</p> Signup and view all the answers

What defines the term 'conjoined twins' in terms of embryonic development?

<p>Conjoined twins are defined as twins that result from the incomplete splitting of the zygote after day 13 of fertilization.</p> Signup and view all the answers

How does the risk of chromosomal abnormalities in monochorionic twin pregnancies compare to singleton pregnancies?

<p>The risk for abnormalities in each fetus in monochorionic twin pregnancies is four times higher than in singleton pregnancies.</p> Signup and view all the answers

What is the chance that at least one twin in a dizygotic pregnancy is affected by a chromosomal defect compared to singleton pregnancies?

<p>The chance is twice as high in dizygotic pregnancies compared to singleton pregnancies of the same maternal age.</p> Signup and view all the answers

Which screening method is considered best for detecting Trisomy 21 in twin pregnancies?

<p>The best method is measurement of fetal nuchal translucency thickness by ultrasound at 10-14 weeks.</p> Signup and view all the answers

What invasive prenatal diagnosis techniques can be performed in twin pregnancies?

<p>Amniocentesis or chorion villus sampling can be performed if necessary.</p> Signup and view all the answers

How does the intrauterine death of one fetus in a twin pregnancy impact the co-twin, particularly in monochorionic pregnancies?

<p>In monochorionic pregnancies, the co-twin faces a 25% risk of death or handicap due to acute haemodynamic shifts.</p> Signup and view all the answers

What complications are unique to monochorionic twin pregnancies?

<p>Complications include placental vascular anastomoses that allow communication between the fetoplacental circulations.</p> Signup and view all the answers

Why is the outcome of a co-twin affected by the intrauterine death of another twin dependent on chorionicity?

<p>The risk level is influenced by whether the twins share the same chorion, with monochorionic twins being at greater risk.</p> Signup and view all the answers

What percentage of monochorionic twin pregnancies face risk due to acute hypotensive episodes if one twin dies?

<p>About 25 percent of cases experience risks associated with acute hypotensive episodes.</p> Signup and view all the answers

What is the chance of miscarriage in a singleton pregnancy between 12 and 23 weeks?

<p>About 1 percent.</p> Signup and view all the answers

How does the risk of premature delivery compare between monochorionic and dichorionic twins?

<p>Monochorionic twins have a 10 percent chance of delivery between 24-32 weeks, while dichorionic twins have a 5 percent chance.</p> Signup and view all the answers

What is the average gestation at delivery for twins?

<p>37 weeks.</p> Signup and view all the answers

How much higher is the perinatal mortality rate in twins compared to singletons?

<p>Around six times higher.</p> Signup and view all the answers

What is the prevalence of low birth weight in dichorionic twins compared to singletons?

<p>It is double the risk for each baby in dichorionic twins compared to singletons.</p> Signup and view all the answers

What should be considered in a dichorionic twin pregnancy where one fetus has intrauterine growth restriction?

<p>The condition of both fetuses should be considered due to the risks of prematurity-related complications.</p> Signup and view all the answers

Why is the risk of complications higher in monochorionic twins compared to dichorionic twins?

<p>Monochorionic twins face additional risks from twin-to-twin transfusion syndrome due to shared circulatory structures.</p> Signup and view all the answers

How does the prevalence of structural abnormalities in dichorionic twin pregnancies compare to singleton pregnancies?

<p>It is the same for each fetus, making the chance of at least one affected fetus twice as high in twins.</p> Signup and view all the answers

What factors contribute to the increased prevalence of gestational diabetes in multiple gestations?

<p>Elevated levels of diabetogenic placental hormones and larger placental area contribute to the increased prevalence.</p> Signup and view all the answers

Why might dietary supplementation for iron and folic acid be necessary during multiple gestations?

<p>There is an increased plasma volume expansion and heightened feto-placental demand for these nutrients, leading to a higher prevalence of anemia.</p> Signup and view all the answers

List some 'minor' symptoms of pregnancy that are more common in multiple gestations.

<p>Gastro-oesophageal reflux, abdominal discomfort, back pain, leg swelling, bladder symptoms, and haemorrhoids.</p> Signup and view all the answers

How does antepartum hemorrhage affect perinatal mortality in multiple gestations?

<p>Antepartum hemorrhage significantly contributes to perinatal mortality due to a larger placental area and additional complications.</p> Signup and view all the answers

What is the relationship between pregnancy in multiple gestations and thromboembolic disease?

<p>Pregnancy in multiple gestations is associated with a higher risk of thromboembolic disease due to physiological alterations and venous compression.</p> Signup and view all the answers

Under what conditions might vaginal delivery be allowed for multiple gestations?

<p>If the first twin is presenting by vertex and there are no other complications, vaginal delivery may be allowed.</p> Signup and view all the answers

What are some reasons obstetricians may prefer elective Caesarean Section for multiple gestations?

<p>Obstetricians may prefer it due to potential complications during the delivery of the second twin that may require instrumental intervention.</p> Signup and view all the answers

What factors should be considered when making a delivery decision in multiple gestations?

<p>Consider previous obstetric history, presentation of the twins, presence of complications, and maternal preferences.</p> Signup and view all the answers

Study Notes

Multiple Gestation (Twin Pregnancy)

  • Multiple gestation is a pregnancy with more than one fetus, occurring in 1-2% of pregnancies.
  • Two-thirds of twin pregnancies are dizygotic, and one-third are monozygotic.

Types and Classification of Twins

  • Dizygotic (Non-identical) Twins
    • Result from the fertilization of two separate eggs.
    • Each twin has its own placenta and amniotic sac (dichorionic diamniotic).
    • Fetuses can be different sexes.
  • Monozygotic (Identical) Twins
    • Result from the splitting of a single fertilized egg.
    • Can share the same placenta (monochorionic), amniotic sac (monoamniotic), or even fetal organs (conjoined twins).
    • Chorionicity and amnionicity depend on the timing of the split:
      • Dichorionic diamniotic: Splitting within the first 3 days after fertilization.
      • Monochorionic diamniotic: Splitting between days 4-8 after fertilization.
      • Monochorionic monoamniotic: Splitting between days 8-12 after fertilization.
      • Conjoined: Splitting after day 13.

Predisposing Factors

  • Dizygotic Twins

    • Ethnic group: Higher in African populations, lower in Asian populations.
    • Maternal age: Increases with age, reaching 2% at age 35.
    • Parity: Increases after four pregnancies.
    • Method of conception: 20% with ovulation induction.
    • Family history
  • Monozygotic Twins

    • No identifiable risk factors.

Complications of Twin Pregnancy

  • Prematurity: Half of twins are delivered preterm (before 37 weeks).
  • Perinatal mortality: Six times higher than singleton pregnancies.
    • Caused mainly by prematurity and twin-to-twin transfusion syndrome (TTTS) in monochorionic twins.
  • Intrauterine growth restriction (IUGR):
    • Higher risk in twins, especially monochorionic twins.
    • Can affect one or both fetuses.
  • Fetal abnormalities:
    • Prevalence of structural abnormalities is higher in twins, especially monochorionic twins.
    • Chromosomal defects are more common in monozygotic twins.
  • Death of one fetus:
    • Can be associated with poor outcomes for the co-twin.
    • Higher risk of death or handicap for co-twin in monochorionic twins due to placental vascular anastomoses.

Management of Twin Pregnancy

  • Antepartum:
    • Gestational diabetes: Routine screening due to increased diabetogenic hormones.
    • Anaemia: Increased prevalence due to increased plasma volume and fetal demand for iron and folic acid.
    • ‘Minor’ symptoms: More common and severe due to increased uterine size and hormones.
    • Antepartum haemorrhage: Increased prevalence due to larger placental area and other complications (hypertensive disease).
    • Thromboembolic disease: Increased risk due to physiological changes and vascular compression.
  • Intrapartum:
    • Mode of delivery:
      • Vaginal delivery possible if the first twin presents vertex and there are no complications.
      • Elective Caesarean section is preferred by some obstetricians.
      • Decision based on obstetric history, presentation, complications, and maternal preference.

Tests for Multiple Gestations

  • Ultrasound: To diagnose multiple gestation and determine chorionicity and amnionicity.
  • Maternal serum biochemistry: Less effective for screening for Trisomy 21 in multiple gestations.
  • Nuchal translucency: Ultrasound measurement at 10-14 weeks to screen for chromosomal defects in each fetus.
  • Invasive prenatal diagnosis: Amniocentesis or chorionic villus sampling performed in specialized centers for accurate and safe fetal sampling.

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Explore the fascinating world of multiple gestation, focusing on twin pregnancies. Learn about the differences between dizygotic and monozygotic twins, including their classifications and unique characteristics. This quiz delves into the intricacies of how twins are formed and their developmental stages.

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