MTOCs and Kinetochore Microtubule Lecture Outline
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Questions and Answers

What is a chromosome in eukaryotic cells?

  • A single strand of DNA
  • A protein wrapped around DNA
  • A double helix of DNA wrapped around histones (correct)
  • A section of RNA that codes for a protein
  • How many chromosomes do humans typically have?

  • 46 (correct)
  • 20
  • 23
  • 50
  • What is the role of cohesins in mitosis?

  • Sites where microtubules connect to chromosomes
  • Move chromosomes to the poles
  • Form rings that hold sister chromatids together (correct)
  • Intermediate filaments that form an interface between the chromosome and nuclear envelope
  • What are condensins responsible for in mitosis?

    <p>Condensing the DNA</p> Signup and view all the answers

    What do kinetochore proteins do in relation to chromosomes?

    <p>Connect microtubules to chromosomes</p> Signup and view all the answers

    What is the function of the spindle apparatus in mitosis?

    <p>Move replicated chromosomes during early mitosis</p> Signup and view all the answers

    Which structure serves as the MTOC in animal cells?

    <p>Centrioles</p> Signup and view all the answers

    What is the function of kinetochore microtubules?

    <p>Attaching to chromosomes</p> Signup and view all the answers

    Which phase of the cell cycle involves cell growth and protein content increase?

    <p>G1 phase</p> Signup and view all the answers

    What defines the two poles of the spindle apparatus?

    <p>Centrioles</p> Signup and view all the answers

    Where do polar microtubules extend from?

    <p>Spindle poles</p> Signup and view all the answers

    Which structure anchors the spindle poles in place?

    <p>Spindle poles</p> Signup and view all the answers

    What is the main difference between prokaryotic and eukaryotic cell division?

    <p>Prokaryotes divide by binary fission, while eukaryotes divide by mitosis and cytokinesis.</p> Signup and view all the answers

    What must happen for a cell to divide successfully?

    <p>Copying the DNA, separating the copies, and dividing the cytoplasm.</p> Signup and view all the answers

    How does a prokaryote differ from a eukaryote in terms of genetic material?

    <p>Prokaryotes have a single circular DNA strand, while eukaryotes have linear chromosomes.</p> Signup and view all the answers

    What are the three essential events that need to happen for a cell to divide?

    <p>Copying the DNA, separating the copies, and dividing the cytoplasm.</p> Signup and view all the answers

    How does a prokaryote cell ensure that each daughter cell gets a copy of replicated DNA?

    <p>Each daughter cell receives one copy of replicated parental DNA.</p> Signup and view all the answers

    What is the difference between prokaryotic and eukaryotic chromosome structures?

    <p>Prokaryotes have a single circular DNA strand forming a chromosome, while eukaryotes have linear chromosomes.</p> Signup and view all the answers

    What is the name of the arrested state in which nondividing cells get permanently stuck in G1 phase?

    <p>G0 state</p> Signup and view all the answers

    Which phase of the cell cycle is essentially eliminated in rapidly dividing cells?

    <p>G1 phase</p> Signup and view all the answers

    What are the two types of defects found in cancerous cells according to the text?

    <p>Defects that activate the proteins required for cell growth when they should be active, and defects that prevent tumour suppressor genes from shutting down the cell cycle.</p> Signup and view all the answers

    What might happen when cells bypass the cell-cycle checkpoints according to the text?

    <p>Cells might form malignant tumours</p> Signup and view all the answers

    How do benign tumours differ from malignant tumours as described in the text?

    <p>Benign tumours are noncancerous and noninvasive; malignant tumours are cancerous and invasive.</p> Signup and view all the answers

    What happens to cells during metastasis according to the text?

    <p>Cells invade surrounding tissues.</p> Signup and view all the answers

    During which phase of the cell cycle does DNA replication occur?

    <p>S phase</p> Signup and view all the answers

    What is the main event in mitosis?

    <p>Division of the replicated chromosomes</p> Signup and view all the answers

    How is cytokinesis different in plant cells compared to animal cells?

    <p>Animal cells form a cell plate during cytokinesis.</p> Signup and view all the answers

    What is the role of the contractile ring in animal cell cytokinesis?

    <p>Pinching the cytoplasm to form a cleavage furrow</p> Signup and view all the answers

    Which phase of the cell cycle involves the preparation for mitosis and cytokinesis?

    <p>G2 phase</p> Signup and view all the answers

    'M Phase' in the cell cycle consists of which two distinct events?

    <p>Mitosis and cytokinesis</p> Signup and view all the answers

    During binary fission, a prokaryote cell replicates its ______

    <p>DNA</p> Signup and view all the answers

    To divide successfully, a cell must satisfy the requirement of each daughter cell receiving the full complement of ______ material

    <p>genetic</p> Signup and view all the answers

    Eukaryotic cells divide by ______ and cytokinesis

    <p>mitosis</p> Signup and view all the answers

    Binary fission in prokaryotes is the process by which a single cell becomes two ______ cells

    <p>daughter</p> Signup and view all the answers

    Prokaryotic cells have a single circular strand of DNA, while eukaryotic cells have ______ chromosomes

    <p>linear</p> Signup and view all the answers

    The process of cell division must ensure that the parent cell contributes sufficient ______ components to each daughter cell

    <p>cytoplasmic</p> Signup and view all the answers

    In eukaryotic cells, a chromosome is a long double helix of DNA wrapped around proteins called __________

    <p>histones</p> Signup and view all the answers

    Every species has a characteristic number of __________

    <p>chromosomes</p> Signup and view all the answers

    Before mitosis, each chromosome is __________

    <p>replicated</p> Signup and view all the answers

    Chromatids attached together are called sister __________

    <p>chromatids</p> Signup and view all the answers

    The spindle apparatus produces mechanical forces that move replicated chromosomes during early mitosis and pull chromatids apart in late __________

    <p>mitosis</p> Signup and view all the answers

    The spindle apparatus is made of __________, formed from microtubule-organizing centres (MTOCs)

    <p>microtubules</p> Signup and view all the answers

    During mitosis, the division of the replicated chromosomes occurs in the ______ phase

    <p>M</p> Signup and view all the answers

    In animal cells, MTOCs are centrosomes, each containing a pair of ______.

    <p>centrioles</p> Signup and view all the answers

    In plant cells, MTOCs are NEDD1 ______.

    <p>complexes</p> Signup and view all the answers

    Cytokinesis in animal cells is initiated by the formation of a ring of actin filaments called the ______ ring

    <p>contractile</p> Signup and view all the answers

    Astral microtubules anchor spindle poles in ______.

    <p>place</p> Signup and view all the answers

    In plant cells, the division of the cell is achieved by constructing a new ______

    <p>cell wall</p> Signup and view all the answers

    Microtubules that attach to chromosomes are called kinetochore ______.

    <p>microtubules</p> Signup and view all the answers

    The fusion of the cell plate with the original cell wall completes cytokinesis in ______ cells

    <p>plant</p> Signup and view all the answers

    The cell cycle consists of two distinct stages: 1) M phase: the time during which the parent cell divides into two daughter ______.

    <p>cells</p> Signup and view all the answers

    During cytokinesis, the cytoplasm of the cell is pinched to form a cleavage furrow in ______ cells

    <p>animal</p> Signup and view all the answers

    The ______ phase of the cell cycle consists of interphase, mitosis, and cytokinesis

    <p>cell cycle</p> Signup and view all the answers

    Cells are growing and preparing for division or are fulfilling their specialized ______.

    <p>functions</p> Signup and view all the answers

    Cell-cycle length can vary greatly among cell types, mostly due to variation in the length of ______ phase.

    <p>G1</p> Signup and view all the answers

    Nondividing cells get permanently stuck in ______ phase. This arrested state is called the G0 state.

    <p>G1</p> Signup and view all the answers

    Cancerous cells have two types of defects: Defects that activate the proteins required for cell growth when they should not be active. Defects that prevent tumour suppressor genes from shutting down the cell cycle. Two types of tumours: Benign tumours are noncancerous and noninvasive. Malignant tumours are cancerous and ______.

    <p>invasive</p> Signup and view all the answers

    Cells that divide without control may form a ______.

    <p>tumour</p> Signup and view all the answers

    Cell-Cycle Checkpoints: There are four cell-cycle checkpoints: G1 checkpoint, G2 checkpoint, ______ checkpoints.

    <p>M-Phase</p> Signup and view all the answers

    Benign tumours are ______ and noninvasive. Malignant tumours are cancerous and invasive.

    <p>noncancerous</p> Signup and view all the answers

    In animal cells, NEDD1 complexes serve as MTOCs.

    <p>False</p> Signup and view all the answers

    The spindle apparatus defines a single pole instead of two poles.

    <p>False</p> Signup and view all the answers

    Polar microtubules extend inward towards each spindle pole.

    <p>False</p> Signup and view all the answers

    Astral microtubules play a role in moving replicated chromosomes during mitosis.

    <p>False</p> Signup and view all the answers

    Kinetochore microtubules attach to chromosomes in animal cells but not in plant cells.

    <p>False</p> Signup and view all the answers

    Centrosomes are the same as MTOCs in animal cells.

    <p>False</p> Signup and view all the answers

    NEDD1 complexes are primarily found in plant cells during cell division.

    <p>False</p> Signup and view all the answers

    Spindle apparatus is responsible for moving replicated chromosomes during late mitosis.

    <p>False</p> Signup and view all the answers

    Kinetochore microtubules attach to the centromere region of replicated chromosomes.

    <p>True</p> Signup and view all the answers

    MTOCs are essential for anchoring spindle poles in place during cell division.

    <p>True</p> Signup and view all the answers

    NEDD1 complexes are responsible for anchoring the spindle poles in place during mitosis

    <p>False</p> Signup and view all the answers

    Centrosomes in animal cells do not contain any microtubules

    <p>True</p> Signup and view all the answers

    The spindle apparatus is directly involved in the division of the cytoplasm during cytokinesis

    <p>False</p> Signup and view all the answers

    Kinetochore microtubules are responsible for anchoring the centrosomes in place during cell division

    <p>False</p> Signup and view all the answers

    Animal cells utilize NEDD1 complexes as their MTOCs during mitosis

    <p>False</p> Signup and view all the answers

    Centrosomes are found in prokaryotic cells.

    <p>False</p> Signup and view all the answers

    The NEDD1 complex is involved in forming the spindle apparatus during mitosis.

    <p>True</p> Signup and view all the answers

    Kinetochore microtubules attach to the centrosomes during cell division.

    <p>False</p> Signup and view all the answers

    MTOCs are only present in animal cells and not in plant cells.

    <p>False</p> Signup and view all the answers

    The spindle apparatus is primarily composed of DNA in eukaryotic cells.

    <p>False</p> Signup and view all the answers

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