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Questions and Answers

What is the primary site of drug metabolism in the body?

  • Lungs
  • Liver (correct)
  • Stomach
  • Kidneys
  • Which enzyme is primarily involved in hepatic metabolism?

  • Cytochrome P-450 (correct)
  • Lipase
  • Amylase
  • Lactase
  • What does the term 'half-life' refer to in pharmacology?

  • The time needed for a drug to be eliminated from the body completely
  • The time it takes for the body to metabolize a drug
  • The amount of time required for the drug concentration to decrease by half (correct)
  • The total duration a drug remains active in the body
  • How is pharmacokinetics primarily defined?

    <p>What the body does to the drug</p> Signup and view all the answers

    What is the main organ responsible for the excretion of drugs?

    <p>Kidneys</p> Signup and view all the answers

    What is the definition of the First-Pass Effect?

    <p>The initial metabolism of a drug in the liver before it reaches systemic circulation</p> Signup and view all the answers

    Which route of administration is considered the fastest for drug absorption?

    <p>Parenteral</p> Signup and view all the answers

    Intravenous (IV) administration bypasses which of the following?

    <p>Hepatic metabolism</p> Signup and view all the answers

    What type of gloves must be worn when administering topical medications?

    <p>STERILE gloves for open skin lesions</p> Signup and view all the answers

    What is the purpose of punctal occlusion during medication administration?

    <p>To reduce systemic absorption of the drug</p> Signup and view all the answers

    What is an important consideration when applying drug drops into the conjunctival sac?

    <p>Dropping prescribed number of drops into the conjunctival sac</p> Signup and view all the answers

    How should ocular ointments be administered?

    <p>With long, smooth strokes towards the inner canthus</p> Signup and view all the answers

    What should be done to the patient's nasolacrimal duct after administering ocular medication?

    <p>Gentle pressure should be applied for 30-60 seconds</p> Signup and view all the answers

    Why should residuals on the patient's skin be removed before applying topical medications?

    <p>To ensure the skin is clean, dry, and irritation-free</p> Signup and view all the answers

    What defines supplemental therapy?

    <p>Treatment that provides necessary substances the body lacks</p> Signup and view all the answers

    Which of the following is NOT one of the rights of medication administration?

    <p>Right Insurance</p> Signup and view all the answers

    What is the primary action of the parasympathetic nervous system neurotransmitter?

    <p>Promote digestion and decrease heart rate</p> Signup and view all the answers

    Which receptors are activated by acetylcholine to produce rest and digest effects?

    <p>Muscarinic receptors</p> Signup and view all the answers

    What is a possible adverse effect of taking antipsychotic drugs?

    <p>Weight gain</p> Signup and view all the answers

    What is the role of atropine sulfate?

    <p>Act as an antidote for cholinergic toxicity</p> Signup and view all the answers

    Which receptor type is primarily associated with increasing heart rate?

    <p>Beta 1 receptors</p> Signup and view all the answers

    Which condition is a contraindication for using antimuscarinic drugs like atropine sulfate?

    <p>Angle-closure glaucoma</p> Signup and view all the answers

    What key syndrome might occur with the use of psychotic drugs?

    <p>Serotonin Syndrome</p> Signup and view all the answers

    Which of the following is true regarding cholinergic drugs?

    <p>They are linked to increased muscle contractions and autonomic activation</p> Signup and view all the answers

    Which of the following should be monitored due to its potential risks?

    <p>Increased suicide ideations</p> Signup and view all the answers

    Which drug interaction should be considered when administering adrenergic agonists?

    <p>Competition for albumin binding</p> Signup and view all the answers

    What effect is associated with stimulation of beta 2 receptors?

    <p>Bronchodilation</p> Signup and view all the answers

    What is the primary purpose of medication reconciliation in a healthcare setting?

    <p>To assess a patient's medication history</p> Signup and view all the answers

    What does positive dromotropy indicate regarding cardiac function?

    <p>Increased AV conduction</p> Signup and view all the answers

    When should medication reconciliation occur during a patient's healthcare journey?

    <p>At multiple points including entry and transfer</p> Signup and view all the answers

    What physiological effect may result from the activation of adrenergic agonists?

    <p>Increased force of contraction</p> Signup and view all the answers

    What role does the liver play in medication metabolism?

    <p>It metabolizes drugs through the first-pass effect</p> Signup and view all the answers

    What should be avoided during the use of CNS stimulants?

    <p>Alcohol and beverages with caffeine</p> Signup and view all the answers

    What is the importance of using the SBAR format in communication?

    <p>It provides structured clarity in communication among healthcare providers</p> Signup and view all the answers

    What is a recommendation for taking medication for maximal effect?

    <p>Take medications on an empty stomach 30-45 minutes before eating</p> Signup and view all the answers

    What monitoring is important for patients following spinal anesthesia?

    <p>Strict bed rest as ordered by the doctor</p> Signup and view all the answers

    What is one critical aspect of preparing a surgical site?

    <p>Checking the patient’s positioning</p> Signup and view all the answers

    What is the primary use of an EpiPen?

    <p>Responding to anaphylactic reactions</p> Signup and view all the answers

    Which adrenergic agonist is commonly used to reverse vasoconstriction caused by catecholamines?

    <p>Phentolamine</p> Signup and view all the answers

    What is a common adverse effect of adrenergic antagonists?

    <p>Abnormal ejaculation</p> Signup and view all the answers

    Which beta blocker is known for its dual action on both beta and alpha receptors?

    <p>Carvedilol</p> Signup and view all the answers

    Which of the following medications is indicated to treat benign prostatic hyperplasia (BPH)?

    <p>Tamsulosin</p> Signup and view all the answers

    What is the recommended way to administer adrenergic agonists to minimize cardiovascular complications?

    <p>Use an infusion pump and infuse slowly</p> Signup and view all the answers

    What are sympatholytics known to inhibit?

    <p>Effects of the sympathetic nervous system</p> Signup and view all the answers

    Concurrent use of which type of medication is contraindicated with adrenergic agonists like epinephrine?

    <p>Erectile dysfunction medications</p> Signup and view all the answers

    Study Notes

    Pharmacology Final Exam Study Guide

    • Otic Medications (Children & Adults):

      • Position patient in a side-lying position with affected ear facing up.
      • Older than 3 years: pull the pinna up and back.
      • Younger than 3 years: pull the pinna down and back.
      • Hold dropper 1 cm above ear canal.
      • Direct drops along the sides of ear canal.
      • Instruct patient to lie on affected side for 5-10 minutes.
      • May insert cotton loosely to prevent leakage.
      • If present, carefully remove cerumen or drainage without pushing it back into the ear canal.
    • Rectal Suppositories:

      • Contraindicated in pts with active rectal bleeding, diarrhea, low platelets, or untreated cardiac arrhythmias.
      • Position patient in Left Lateral Sims Position.
      • Use water-based lubricant.
      • Insert suppository at least 4 inches beyond internal sphincter.
      • Patient to remain on the left side for 15-20 minutes.
    • Vaginal Suppositories:

      • Patient to empty bladder before administration.
      • Absorption may take 4-12 hours.
      • Use water-based lubricant.
      • Position patient in Lithotomy position.
      • Remain in supine position for 5-10 minutes to allow absorption.
    • Transdermal Patches (RN Considerations):

      • Remove old patch and discard.
      • Cleanse skin area of old patch.
      • Observe for skin irritations.
      • Rotate patch application sites for new patches.
      • Apply new patch to a hairless, scratch-free area.
      • Avoid cutting patches; this releases all medication at once.
      • Ensure patch edges adhere flat to the skin.
      • Document the new patch location.
    • Nasal Medications:

      • Explain that temporary burning/stinging may occur.
      • Evaluate patient's history of nasal surgeries/trauma.
      • Have patient blow nose to clear passages (unless contraindicated, e.g., increased ICP or recent nasal surgery).
      • Nasal Drops: Hold dropper ½ inch above desired nostril. Instill drops per order. Maintain supine position for 5 minutes at minimum. Infants (nose breathers) should receive nasal drops 20-30 minutes before feeding.
      • Nasal Spray: Patient sitting upright. Occlude one nostril with gloved finger. Point tip toward side of nose, not center. Squeezes spray as pt inhales.
    • Ophthalmic Medications:

      • Pull lower eyelid down with one hand.
      • Hold eye drops 1-2 cm above conjunctival sac.
      • Do not touch dropper tip to eye or with fingers.
      • Apply prescribed drops to the conjunctival sac.
      • Punctial occlusion (for glaucoma patients): Occlude lacrimal punctum using finger.
      • Ointment administration: Similar to drops, but gently squeeze medication from inner to outer canthus.
    • General Medication Administration (Important Considerations):

      • Wear gloves for all medication applications, especially if applying to open skin lesions.
      • Ensure medication is applied to clean, dry, irritation-free skin.
      • Allow time for medication absorption according to the specifics of the medication.
      • Apply medications appropriately following the direction of hair growth, especially for elderly patients.

    Other Topics

    • Medication Errors: Report all medication errors and near misses, do not attempt to fix them.
    • Medication Rights: Understand the 10 Rights of Medication Administration( Right patient, drug, dose, route, time, documentation, indication, response, to refuse and education)
    • First-Pass Effect: Drug-metabolization at a specific location that reduces active drug concentration before reaching site of action.
    • Pharmacodynamics: The effect a drug has on the body.
    • Pharmacokinetics: What the body does to a drug.
    • Half-life: Defined as the time taken for a substance to reduce to half of its initial concentration.
    • Empiric Therapy: Treatment given before definite diagnosis based on experience.
    • Prophylactic Therapy: preventing a disease or condition.
    • Supplemental Therapy: Providing substances lacking in the body.
    • Parenteral Administration: Includes injections like IV, IM, subcutaneous (subQ), and intrathecal (intra-arterial/intra-articular).

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