MRI Contrast Agents
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Questions and Answers

Explain the theory of operation behind MRI contrast agents.

MRI contrast agents work by shortening or altering the T1 relaxation time of nearby water protons, which affects the contrast in the MR image by changing the spin polarization detected by the receiver.

How do MRI scanners polarize the hydrogen nuclei in body tissues?

MRI scanners expose sections of the body to a strong magnetic field, causing the hydrogen nuclei of water in tissues to be polarized in the direction of the magnetic field.

What is the role of gadolinium-based contrast agents (GBCAs) in MRI?

Gadolinium-based contrast agents are the most commonly used compounds for contrast enhancement in MRI, as they help improve the visibility of internal body structures.

What is the main source of contrast in MR images, according to the text?

<p>The different T1 values of water protons in different tissues are one of the main sources of contrast in MR images.</p> Signup and view all the answers

How do contrast agents affect the T1 relaxation time of nearby water protons?

<p>Contrast agents usually shorten, but in some instances can increase, the value of T1 of nearby water protons, thereby altering the contrast in the image.</p> Signup and view all the answers

Who were the researchers who obtained the first MR images of a human brain in 1978?

<p>Ian Robert Young and Hugh Clow</p> Signup and view all the answers

What technique did Arno Villringer and colleagues demonstrate in 1988?

<p>Susceptibility contrast agents in perfusion MRI</p> Signup and view all the answers

Who recognized that oxygen-depleted blood with dHb was attracted to a magnetic field, leading to the discovery of the technique underlying Functional Magnetic Resonance Imaging (fMRI)?

<p>Seiji Ogawa at AT&amp;T Bell labs</p> Signup and view all the answers

In the early 1980s to the early 1990s, what inspiration led to the use of 'Jedi' helmets in MRI?

<p>'Return of the Jedi' Star Wars film</p> Signup and view all the answers

What was the purpose of the 'Jedi' helmets worn by children in MRI in the early 1980s to the early 1990s?

<p>To obtain good image quality and encourage children to not be frightened by the procedure</p> Signup and view all the answers

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