Skills: Inflammatory & Rheumatologic Disorders Diagnostics
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Questions and Answers

Which of the following conditions is associated with an elevated erythrocyte sedimentation rate (ESR)?

  • Osteoarthritis
  • Gout
  • Rheumatoid arthritis (RA) (correct)
  • Systemic lupus erythematosus (SLE)

    • Compared to the erythrocyte sedimentation rate (ESR), the C-reactive protein (CRP) is considered:

  • More sensitive for detecting inflammation (correct)
  • Unrelated to the detection of inflammation
  • Equally sensitive as ESR for detecting inflammation
  • Less sensitive for detecting inflammation

    • The antinuclear antibody (ANA) test is ordered when there is a suspicion of:

  • Osteoarthritis
  • Gout
  • Systemic lupus erythematosus (SLE) or other connective tissue disease (correct)
  • Rheumatoid arthritis

    • A high ANA titer suggests:

    <p>The patient is more likely to have a connective tissue disease</p> Signup and view all the answers

    In the context of ANA testing, the 'homogenous/rim pattern' on immunofluorescence is associated with:

    <p>Systemic lupus erythematosus (SLE)</p> Signup and view all the answers

    The 'speckled pattern' on ANA immunofluorescence is associated with:

    <p>Sjögren's syndrome</p> Signup and view all the answers

    Which condition is most commonly associated with a positive antinuclear antibody (ANA) test?

    <p>Systemic lupus erythematosus (SLE)</p> Signup and view all the answers

    Which antibody test is considered the hallmark for the diagnosis of systemic lupus erythematosus (SLE)?

    <p>Anti-double-stranded DNA antibodies</p> Signup and view all the answers

    Which condition is most strongly associated with the presence of anti-cyclic citrullinated peptide antibodies (anti-CCP)?

    <p>Rheumatoid arthritis (RA)</p> Signup and view all the answers

    Which antibody test is considered to have the greatest specificity for systemic lupus erythematosus (SLE), but low sensitivity?

    <p>Anti-Smith antibodies</p> Signup and view all the answers

    Which condition is most strongly associated with elevated uric acid levels?

    <p>Gout</p> Signup and view all the answers

    Which antibody test is recommended for patients with pulmonary-renal syndrome, rapidly progressive renal failure, mononeuritis multiplex, or pulmonary hemorrhage?

    <p>Antineutrophil cytoplasmic antibodies (ANCA)</p> Signup and view all the answers

    In the context of ANA testing, a "nucleolar pattern" on immunofluorescence is associated with:

    <p>Scleroderma</p> Signup and view all the answers

    Hallmark test of ankylosing spondylitis (present in 95% of those with disease):

    <p>HLA-B27</p> Signup and view all the answers

    synovial fluid findings!

    Signup and view all the answers

    Compare and contrast the exam/diagnostic findings and common rheumatologic diseases associated with the following types of joint fluid:

    <p>joint fluid may be found in healthy individuals or those with mild joint irritation = Normal CBC is mildly elevated, usually less than 2000 cells/μL, primarily mononuclear cells = Non-inflammatory WBC elevated, often greater than 2000 cells/μL, predominantly neutrophils = Inflammatory WBC: Markedly elevated, often greater than 50,000 cells/μL, predominantly neutrophils = Purulent/septic</p> Signup and view all the answers

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