Mouse Intraperitoneal Glucose Tolerance Test (IPGTT) in Diabetes Research

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Questions and Answers

What is the purpose of an intraperitoneal glucose tolerance test (IPGTT) in mice?

  • To assess insulin levels in response to glucose administration
  • To measure the clearance of an intraperitoneally injected glucose load from the body (correct)
  • To determine the fasting blood glucose levels before glucose injection
  • To evaluate the impact of medication on glucose homeostasis

What is one of the key requirements for animals undergoing IPGTT?

  • Exercising for at least 30 minutes daily
  • Being hydrated with water for 24 hours
  • Consuming a high-fat diet for 2 weeks
  • Fasting for approximately 16 hours (correct)

Which factor may vary in different GTT variations?

  • The ambient temperature during the test
  • Blood-sampling intervals (correct)
  • The color of the solution injected
  • The type of anesthesia used

What does IPGTT primarily assess in mice?

<p>Glucose homeostasis under in vivo conditions (C)</p> Signup and view all the answers

What is the duration for which blood glucose level is measured during IPGTT?

<p>2 hours (C)</p> Signup and view all the answers

In addition to blood glucose concentrations, what else may be assessed during GTT variations?

<p>Various metabolites and hormones (C)</p> Signup and view all the answers

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