Mometasone and Cromolyn

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Questions and Answers

What is the primary mechanism of action of mometasone in treating allergic rhinitis?

  • Blocking histamine receptors to alleviate symptoms.
  • Stabilizing mast cells to prevent histamine release.
  • Decongesting nasal passages by constricting blood vessels.
  • Reducing inflammation by inhibiting the release of inflammatory mediators. (correct)

A patient using mometasone for allergic rhinitis reports experiencing frequent nosebleeds. What is the most appropriate initial recommendation?

  • Reduce the dosage of mometasone and use a nasal saline spray to moisten the nasal passages. (correct)
  • Add an oral decongestant to counteract the nosebleeds.
  • Discontinue mometasone use immediately and switch to an antihistamine.
  • Increase the dosage of mometasone to reduce inflammation more effectively.

Which allergic symptom is mometasone most effective in treating?

  • Nasal congestion and inflammation associated with allergic rhinitis. (correct)
  • Bronchospasm and wheezing due to allergic asthma.
  • Immediate relief from acute urticaria (hives).
  • Gastrointestinal symptoms related to food allergies.

What is the mechanism of action of cromolyn sodium in managing allergic symptoms?

<p>Stabilizing mast cells, preventing the release of histamine and other inflammatory mediators. (C)</p> Signup and view all the answers

A patient using a cromolyn nebulizer reports experiencing a burning sensation in their throat. What is the proper course of action?

<p>Temporarily stop using the nebulizer and consult with their healthcare provider for guidance. (B)</p> Signup and view all the answers

Which allergic symptom is cromolyn primarily used to manage?

<p>Prevention of exercise-induced asthma symptoms. (D)</p> Signup and view all the answers

What is a significant limitation associated with cromolyn use for allergy management?

<p>It requires frequent administration and has a delayed onset of action. (A)</p> Signup and view all the answers

A patient is prescribed both intranasal mometasone and intranasal cromolyn. How should they be advised to use these medications?

<p>Use cromolyn first as a preventative measure, followed by mometasone to address breakthrough symptoms. (C)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with intranasal cromolyn but NOT with mometasone?

<p>Sneezing after administration. (D)</p> Signup and view all the answers

Why is adherence to the prescribed regimen particularly important for patients using cromolyn?

<p>Due to its short half-life and need for consistent mast cell stabilization. (A)</p> Signup and view all the answers

Which statement best describes the mechanism by which mometasone reduces allergic rhinitis symptoms?

<p>It binds to intracellular glucocorticoid receptors, modifying gene transcription to reduce inflammation. (C)</p> Signup and view all the answers

A patient with severe seasonal allergies is not responding adequately to intranasal mometasone. What is the most appropriate next step in managing this patient's symptoms?

<p>Prescribe a short course of oral corticosteroids while continuing mometasone. (D)</p> Signup and view all the answers

A patient using intranasal mometasone complains of a persistent sore throat and hoarseness. What is the most likely cause?

<p>Improper administration technique causing deposition of the medication in the oropharynx. (A)</p> Signup and view all the answers

Which aspect of allergic rhinitis is mometasone LEAST effective in treating?

<p>Ocular pruritus. (D)</p> Signup and view all the answers

How does cromolyn sodium prevent allergic reactions at the cellular level?

<p>By inhibiting the release of inflammatory mediators from mast cells. (B)</p> Signup and view all the answers

A patient using a cromolyn nebulizer for asthma reports developing a persistent dry cough. What is the most appropriate intervention?

<p>Ensure adequate hydration and consider using a bronchodilator prior to cromolyn inhalation. (B)</p> Signup and view all the answers

For which specific allergic symptom is cromolyn considered a first-line treatment?

<p>Prophylaxis of exercise-induced bronchospasm. (D)</p> Signup and view all the answers

What is the primary limitation of cromolyn sodium compared to other allergy medications like antihistamines and corticosteroids?

<p>Requires frequent administration for optimal effect. (C)</p> Signup and view all the answers

A patient is using both intranasal mometasone and intranasal cromolyn for seasonal allergies. What instruction regarding their use is MOST important?

<p>Administer mometasone first to reduce nasal congestion and allow better penetration of cromolyn. (D)</p> Signup and view all the answers

Why is patient education regarding proper administration technique particularly critical for cromolyn, compared to other intranasal medications?

<p>Cromolyn requires direct contact with mast cells to be effective, necessitating precise application. (B)</p> Signup and view all the answers

Flashcards

Mometasone MOA

Reduces inflammation in the nasal passages by inhibiting the release of inflammatory mediators.

Mometasone Adverse Effects

Local irritation, nosebleeds, headache.

Symptoms Mometasone Treats

Nasal congestion, sneezing, runny nose, itchy nose.

Cromolyn MOA

Prevents the release of histamine and other inflammatory substances from mast cells, reducing allergic reactions.

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Cromolyn Adverse Effects

Intranasal: nasal irritation; Nebulizer: cough, wheezing.

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Cromolyn Treatable Symptoms

Runny nose, sneezing, itching. Best for preventing symptoms before exposure.

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Cromolyn Use Issues

Requires frequent administration (several times daily) and needs to be started before exposure to allergens for best effect.

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Study Notes

  • Mometasone is an intranasal corticosteroid.

Mometasone

  • Mechanism of Action: It reduces inflammation.
  • Adverse Effects: Can lead to local irritation, nosebleeds, and rarely, systemic effects.
  • Allergic Symptoms: Effective for nasal congestion, sneezing, and runny nose.

Cromolyn

  • Cromolyn is a mast cell stabilizer.
  • Mechanism of Action: Prevents the release of histamine and other inflammatory mediators from mast cells.
  • Adverse Effects:
    • Intranasal: Nasal irritation and stinging.
    • Nebulizer: Cough and wheezing.
  • Allergic Symptoms: Works best for preventing allergic rhinitis symptoms, such as sneezing and runny nose.
  • Issues with Use and Administration: Requires frequent administration and is less potent than corticosteroids.

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