10 Questions
What type of docking considers both receptor and ligand flexibility?
Flexible docking
In which type of docking are both partners treated as rigid?
Rigid body docking
What is the primary goal of 'bound' docking?
Reconstructing the original complex of two molecules
What is the critical element in a search procedure according to the text?
Effectiveness in covering relevant conformational space
Which type of docking requires considering the active site of the protein?
Targeted docking
What is the primary difference between bound and unbound docking?
'Bound' docking involves splitting co-crystallized molecules, while 'unbound' uses them as is.
Which type of docking tests the validity of algorithms by reconstructing original complexes?
'Bound' docking
'(Pseudo/Semi)-Flexible ligand docking' mainly focuses on which element being flexible?
'Ligand'
'Grid Generation Construction' is primarily associated with which aspect of molecular docking?
'Blind' docking
'Speed and effectiveness in covering relevant conformational space' are highlighted as critical in which phase of molecular docking?
'Blind' docking
Learn about the common imperfections in scoring functions used in molecular docking programs, which are a major limiting factor in accuracy. Discover how simplifications and assumptions made in scoring functions can impact the evaluation of ligand affinity.
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