Molecular Biology of the Cell (6th Edition) Quiz
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Questions and Answers

What happens to properly folded proteins in the ER?

  • They stay in the ER indefinitely.
  • They leave the ER to take different routes in biosynthetic-secretory pathways. (correct)
  • They are transported back to the cytoplasm.
  • They are degraded in the ER.
  • Which process involves the retrograde transport of proteins from the Golgi apparatus back to the ER?

  • Endocytosis
  • Exocytosis
  • Anterograde transport
  • Retrograde transport (correct)
  • In vesicular traffic, what is the function of different coats?

  • Prevent vesicle formation
  • Aid in protein synthesis
  • Regulate vesicle transport between different compartments (correct)
  • Only provide structural support to vesicles
  • In a polarised cell, what process involves the internalization of extracellular substances through invagination of the cell membrane?

    <p>Endocytosis</p> Signup and view all the answers

    Which organelle is involved in post-translational modification and packaging of proteins before they move via Golgi?

    <p>Endoplasmic reticulum</p> Signup and view all the answers

    What is the main mechanism cells use to package and transport proteins for export?

    <p>Exocytosis</p> Signup and view all the answers

    What is the primary function of the endoplasmic reticulum mentioned in the text?

    <p>Protein biosynthesis</p> Signup and view all the answers

    How are signal sequences typically positioned in proteins targeted to the endoplasmic reticulum?

    <p>N-terminus</p> Signup and view all the answers

    Which process involves the removal of signal sequences by signal peptidases?

    <p>Protein translocation</p> Signup and view all the answers

    In cotranslational translocation to the ER, where does the polypeptide chain pass through?

    <p>Aqueous pore in the Sec61 complex</p> Signup and view all the answers

    How are membrane proteins typically inserted into the ER membranes?

    <p>Lipid-anchored protein</p> Signup and view all the answers

    Which cellular process involves the use of different coats for vesicular traffic?

    <p>Exocytosis</p> Signup and view all the answers

    What is the main mechanism by which proteins are sent for degradation if they fail to fold in the ER?

    <p>Proteins are tagged with ubiquitin for degradation</p> Signup and view all the answers

    How does the ER determine if a protein is ready to leave after folding?

    <p>By interactions with ER-resident chaperones</p> Signup and view all the answers

    In the context of ER protein folding and quality control, what role do chaperones play?

    <p>Chaperones facilitate protein folding and prevent aggregation</p> Signup and view all the answers

    Which process occurs during protein post-translational modification in the ER?

    <p>Removal of signal peptides from newly synthesized proteins</p> Signup and view all the answers

    What is the fate of misfolded proteins in the ER that cannot be properly refolded?

    <p>They are targeted for degradation by the proteasome</p> Signup and view all the answers

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