Podcast
Questions and Answers
What is the primary function of helicase in DNA replication?
What is the primary function of helicase in DNA replication?
- It ligates Okazaki fragments.
- It unwinds the DNA double helix. (correct)
- It synthesizes RNA primers.
- It adds nucleotides to the growing strand.
Which enzyme is primarily responsible for adding nucleotides during DNA replication?
Which enzyme is primarily responsible for adding nucleotides during DNA replication?
- Topoisomerase
- Helicase
- Ligase
- DNA polymerase (correct)
In the context of leading and lagging strand synthesis, which statement is correct?
In the context of leading and lagging strand synthesis, which statement is correct?
- Both strands are synthesized in a continuous manner.
- Leading strand synthesis is slower than lagging strand synthesis.
- DNA polymerase moves away from the replication fork on the leading strand.
- Lagging strand synthesis requires multiple RNA primers. (correct)
What is the consequence of a loss of the 3’ hydroxyl group during nucleotide addition?
What is the consequence of a loss of the 3’ hydroxyl group during nucleotide addition?
How do topoisomerase I and topoisomerase II differ in their mechanisms?
How do topoisomerase I and topoisomerase II differ in their mechanisms?
What role does the helicase perform during the replication process?
What role does the helicase perform during the replication process?
Which statement about Okazaki fragments is correct?
Which statement about Okazaki fragments is correct?
Why are multiple origins of replication necessary in eukaryotic cells?
Why are multiple origins of replication necessary in eukaryotic cells?
What is the primary function of DNA ligase during the replication process?
What is the primary function of DNA ligase during the replication process?
What function does the primer serve during DNA replication?
What function does the primer serve during DNA replication?
During which phase of the cell cycle does DNA replication primarily occur?
During which phase of the cell cycle does DNA replication primarily occur?
What is the consequence of errors during DNA replication?
What is the consequence of errors during DNA replication?
Which mechanism is responsible for relieving torsional strain during replication?
Which mechanism is responsible for relieving torsional strain during replication?
What characterizes the early replication regions in DNA replication?
What characterizes the early replication regions in DNA replication?
Which component of the pre-replication complex (Pre-RC) is crucial for initiating replication licensing?
Which component of the pre-replication complex (Pre-RC) is crucial for initiating replication licensing?
How does transcription influence the process of DNA replication?
How does transcription influence the process of DNA replication?
What is the primary role of DNA pol I in prokaryotic DNA replication?
What is the primary role of DNA pol I in prokaryotic DNA replication?
What unique challenge does the end-replication problem present for linear chromosomes?
What unique challenge does the end-replication problem present for linear chromosomes?
What differentiates lagging strand synthesis from leading strand synthesis?
What differentiates lagging strand synthesis from leading strand synthesis?
What is the function of topoisomerases in DNA replication?
What is the function of topoisomerases in DNA replication?
Which of these DNA polymerases is primarily responsible for elongating the leading strand in eukaryotes?
Which of these DNA polymerases is primarily responsible for elongating the leading strand in eukaryotes?
Which sequence characteristic is typical of late replication regions?
Which sequence characteristic is typical of late replication regions?
What role does Flap Endonuclease (FEN1) play in the finalization of DNA synthesis?
What role does Flap Endonuclease (FEN1) play in the finalization of DNA synthesis?
How does rolling circle replication differ from conventional replication?
How does rolling circle replication differ from conventional replication?
What is the consequence of having insufficient 3’OH during DNA synthesis?
What is the consequence of having insufficient 3’OH during DNA synthesis?
In which type of DNA replication does the nuclease cut one DNA strand to initiate replication?
In which type of DNA replication does the nuclease cut one DNA strand to initiate replication?
What factors primarily determine the locations of late replication regions in organisms?
What factors primarily determine the locations of late replication regions in organisms?
Which of the following is NOT a subunit of DNA pol III in prokaryotes?
Which of the following is NOT a subunit of DNA pol III in prokaryotes?
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