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Questions and Answers
What is the aim of the mixing study in checking abnormal clotting time result?
What is the aim of the mixing study in checking abnormal clotting time result?
- To immediately measure the PT or aPTT
- To confirm the presence of a circulating inhibitor
- To select the factor assay
- To differentiate clotting time prolongation due to a coagulation factor deficiency or an inhibitor (correct)
What is the basic principle behind the mixing study?
What is the basic principle behind the mixing study?
- To correct for a factor deficiency using normal plasma (correct)
- To confirm a circulating inhibitor
- To measure the PT or aPTT
- To incubate the patient plasma with normal pooled plasma
When does the mixing study take place?
When does the mixing study take place?
- After selecting the factor assay
- After confirming the presence of a circulating inhibitor
- Immediately after PT or aPTT measured or incubated (correct)
- Before measuring the PT or aPTT
What does a corrected clotting time after mixing suggest?
What does a corrected clotting time after mixing suggest?
What is the significance of confirming probable coagulation deficiencies?
What is the significance of confirming probable coagulation deficiencies?
What does a clotting time that does not correct after mixing suggest?
What does a clotting time that does not correct after mixing suggest?
In which pathway does the activation of factor 7 occur?
In which pathway does the activation of factor 7 occur?
Which factor is responsible for the activation of factor 10 in the extrinsic pathway?
Which factor is responsible for the activation of factor 10 in the extrinsic pathway?
Where does the intrinsic pathway begin?
Where does the intrinsic pathway begin?
What role does factor 13 play in the clotting process?
What role does factor 13 play in the clotting process?
Which pathway ultimately leads to the formation of a fibrin network that covers the surface of the platelet plug?
Which pathway ultimately leads to the formation of a fibrin network that covers the surface of the platelet plug?
What is the initial source of tissue factor in the extrinsic pathway?
What is the initial source of tissue factor in the extrinsic pathway?
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Study Notes
Mixing Study
- The aim of the mixing study is to check abnormal clotting time results by mixing the patient's plasma with normal plasma.
- The basic principle behind the mixing study is to identify whether the abnormal clotting time is due to a factor deficiency or an inhibitor.
Clotting Pathways
- The mixing study takes place when a patient's clotting time is abnormal to determine the cause of the abnormality.
- A corrected clotting time after mixing suggests that the abnormality is due to a factor deficiency.
- Confirming probable coagulation deficiencies is significant because it helps identify the underlying cause of bleeding disorders.
Coagulation Factors
- A clotting time that does not correct after mixing suggests the presence of an inhibitor.
- Factor 7 is activated in the extrinsic pathway.
- Factor 7 is responsible for the activation of factor 10 in the extrinsic pathway.
- The intrinsic pathway begins with the activation of factor 12 (Hageman factor).
- Factor 13 (fibrin-stabilizing factor) plays a role in the clotting process by cross-linking fibrin strands to form a stable clot.
- The extrinsic pathway ultimately leads to the formation of a fibrin network that covers the surface of the platelet plug.
- The initial source of tissue factor in the extrinsic pathway is damaged tissue cells or cells in the blood vessel wall.
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