Podcast
Questions and Answers
Which statement correctly describes the flow characteristics of lactose?
Which statement correctly describes the flow characteristics of lactose?
- Lactose exhibits a greater volume drop compared to corn starch.
- Lactose has a high angle of repose indicating poor flow.
- Lactose particles are too large to form cohesive bonds. (correct)
- Lactose is hygroscopic, leading to moisture interference.
What implication does a 35% drop in volume upon tapping corn starch suggest?
What implication does a 35% drop in volume upon tapping corn starch suggest?
- Corn starch has good flow characteristics.
- Corn starch particles are larger than those of lactose.
- Corn starch is unsuitable for applications requiring high density.
- Corn starch displays signs of cohesion. (correct)
What is indicated by an angle of repose greater than 40°?
What is indicated by an angle of repose greater than 40°?
- The material has excellent flow.
- The material has good powder mixing capability.
- The material exhibits poor flow characteristics. (correct)
- The material experiences pass flow conditions.
What does a low tapped bulk density indicate about a powder?
What does a low tapped bulk density indicate about a powder?
How is the angle of repose calculated in relation to a cone of powder?
How is the angle of repose calculated in relation to a cone of powder?
What is a significant disadvantage of convective mixers?
What is a significant disadvantage of convective mixers?
Which type of mixer is characterized by high rotational speeds and is used to mix powders with high energy input?
Which type of mixer is characterized by high rotational speeds and is used to mix powders with high energy input?
What is a key advantage of using cube, cone, and V mixers?
What is a key advantage of using cube, cone, and V mixers?
What potential issue is associated with the physical setup of planetary mixing?
What potential issue is associated with the physical setup of planetary mixing?
What distinguishes high shear mixers from other types of mixers?
What distinguishes high shear mixers from other types of mixers?
What characteristic of tightly packed powders results in minimal air entrapped?
What characteristic of tightly packed powders results in minimal air entrapped?
What is the porosity percentage of loosely packed powders?
What is the porosity percentage of loosely packed powders?
What packing arrangement is characterized by the densest packing and a porosity of approximately 26%?
What packing arrangement is characterized by the densest packing and a porosity of approximately 26%?
Which statement about porosity is true?
Which statement about porosity is true?
What is the primary method to determine porosity in powders?
What is the primary method to determine porosity in powders?
In powder characterization, what does 'bulk density' refer to?
In powder characterization, what does 'bulk density' refer to?
What is the relationship between the 'true density' and 'particle density'?
What is the relationship between the 'true density' and 'particle density'?
Which combination of coarse and fine particles results in the densest packing arrangement?
Which combination of coarse and fine particles results in the densest packing arrangement?
What is indicated by a Carr's compressibility index greater than 33%?
What is indicated by a Carr's compressibility index greater than 33%?
What happens to the final volume during the determination of tapped density?
What happens to the final volume during the determination of tapped density?
How does the Hausner ratio relate to powder flow properties?
How does the Hausner ratio relate to powder flow properties?
What is the primary purpose of measuring tapped density?
What is the primary purpose of measuring tapped density?
What is the relationship between bulk density and tapped density?
What is the relationship between bulk density and tapped density?
Which factor contributes to a larger difference between poured and tapped densities?
Which factor contributes to a larger difference between poured and tapped densities?
In powder flow characterization, what is the significance of added glidant?
In powder flow characterization, what is the significance of added glidant?
What does apparent porosity represent in the context of particles?
What does apparent porosity represent in the context of particles?
What is the primary aim of powder mixing in pharmaceutical processes?
What is the primary aim of powder mixing in pharmaceutical processes?
Which mixing technique involves adding a liquid phase to powders?
Which mixing technique involves adding a liquid phase to powders?
How do tumbler mixers primarily affect the mixing of powders?
How do tumbler mixers primarily affect the mixing of powders?
Which of the following describes the process of pre-mixing?
Which of the following describes the process of pre-mixing?
What is a key benefit of dry mixing compared to wet mixing?
What is a key benefit of dry mixing compared to wet mixing?
What role does mechanical screw feeding play in powder handling?
What role does mechanical screw feeding play in powder handling?
Which property of the powder mixture is most affected by the mixing process?
Which property of the powder mixture is most affected by the mixing process?
In the context of powder transport, what is the purpose of using a vacuum?
In the context of powder transport, what is the purpose of using a vacuum?
What is the primary purpose of an impaction mixer?
What is the primary purpose of an impaction mixer?
What is a primary concern when selecting a mixer for powder materials?
What is a primary concern when selecting a mixer for powder materials?
Which of the following mixing mechanisms is primarily responsible for the movement of entire groups of particles?
Which of the following mixing mechanisms is primarily responsible for the movement of entire groups of particles?
What is a potential safety hazard associated with mixing powders?
What is a potential safety hazard associated with mixing powders?
Which type of mixer is best suited for free-flowing powders?
Which type of mixer is best suited for free-flowing powders?
What loading ratio is typically optimal for convective mixers?
What loading ratio is typically optimal for convective mixers?
In which scenario would electrostatic charging be a significant concern during mixing?
In which scenario would electrostatic charging be a significant concern during mixing?
What is the effect of particle size, shape, and density differences during mixing?
What is the effect of particle size, shape, and density differences during mixing?
Flashcards
Porosity
Porosity
The extent to which air spaces exist between particles in a powder. It's a measure of how much air is present in a powder sample.
Poured bulk volume
Poured bulk volume
The most loosely packed state of a powder, achieved by simply pouring it into a measuring cylinder without any vibration or disturbance.
Tapped bulk volume
Tapped bulk volume
The densest packing state achieved by applying pressure or tapping the measuring cylinder to allow the particles to settle.
Packing Arrangement
Packing Arrangement
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Dense Packing
Dense Packing
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Particle Density
Particle Density
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Bulk Density
Bulk Density
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True Density
True Density
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Angle of Repose
Angle of Repose
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Funnel Flow
Funnel Flow
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Aspect Ratio (AR) > 1.7
Aspect Ratio (AR) > 1.7
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Poured Bulk Density
Poured Bulk Density
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Tapped Bulk Density
Tapped Bulk Density
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Tapped Density
Tapped Density
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Carr's Compressibility Index
Carr's Compressibility Index
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Hausner Ratio
Hausner Ratio
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Glidant
Glidant
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Density Difference
Density Difference
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Convective Mixer
Convective Mixer
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Impaction Mixer
Impaction Mixer
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High Shear Mixing
High Shear Mixing
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Nauta® Mixer
Nauta® Mixer
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Tumbling Mixer
Tumbling Mixer
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Dry mixing
Dry mixing
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Wet mixing
Wet mixing
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Pre-mixing
Pre-mixing
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Post-mixing
Post-mixing
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Tumbler mixers
Tumbler mixers
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Powder transport
Powder transport
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Powder mixing
Powder mixing
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Fluidized bed mixing
Fluidized bed mixing
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Optimal Loading Ratio
Optimal Loading Ratio
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Diffusion
Diffusion
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Convection
Convection
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Shear
Shear
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Segregation
Segregation
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Maintaining Adequate Mix
Maintaining Adequate Mix
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Study Notes
Preformulation - Bulk Powder Properties
- Powders can exist in various packing states, from loosely packed (maximum airspace) to tightly packed (minimum airspace).
- Particle size and shape influence packing density, with smaller particles filling voids between larger ones.
- Porosity, the amount of air space between particles, is inversely related to packing density.
- Loose packing has approximately 48% porosity, and dense packing has approximately 26% porosity.
- Coarse and fine particles have approximately 55% porosity.
Determination of Porosity
- Powder is placed in a measuring cylinder without vibration to determine the poured bulk volume (V₁).
- The poured bulk density (ρ♭) is the reciprocal of the poured bulk volume.
- The void volume (Vp) is the difference between the poured bulk volume and the particle volume.
- Porosity is calculated by dividing the void volume by the total bulk volume.
Determination of Tapped Density
- Powder is placed in a cylinder and tapped to determine the tapped volume (Vt).
- The tapped density (ρt) is the reciprocal of the tapped volume.
- Tapping increases packing density and reduces porosity.
- This measurement is used to evaluate the dynamic powder packing characteristics.
Flow Properties
- Interparticulate forces (e.g., Van der Waals, electrostatic) influence packing and flow.
- Difference between poured and tapped densities indicates cohesion.
- Increased tapping requires more energy for tighter packing.
- Carr's compressibility index and Hausner ratio metrics predict flow properties from packing characteristics.
Hopper Design and Flow
- Funnel flow - some powder remains stationary, while mass flow involves all powder in motion.
- Funnel flow and rat holing are associated with shallow angle orifices and can cause segregation.
- Mass flow is superior, and offers uniform flow with constant density.
- Steep orifice angles minimize rat holing problems.
Flow Improvement
- Particle size, shape, charge, and moisture influence flow.
- Glidants are utilized to improve flow by smoothing particle surfaces.
- Hoppers, aeration, and force feed mechanisms improve powder flow.
Powder Mixing
- Mixing is essential to produce homogeneous distributions of powder components.
- Components mixing variables include: particle size, shape, and density.
- Mixing's outcome influences subsequent processes like granulation, tabletting, and capsule filling.
- Mixing involves dry mixing (without liquid) and wet mixing (with liquid binder, such as granulation).
- Different mixing methods (e.g., tumbler, convective, planetary) have differing efficiency for various particle types.
Interactive Powder Mixtures
- Interactive/ordered powder mixtures result from cohesive, fine particles forming ordered units, improving homogeneity.
- Factors like particle size and density affect segregation, while vibration and segregation (including different types) relate to stability.
Segregation as a Problem
- Segregation is a problematic issue in powder mixtures due to particle differences in size and shape, potentially leading to uneven or non-homogenous mixtures.
- Strategies for mitigating segregation include the careful selection of components with similar particle size and density, and/or improved mixer/process design.
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