Powder Properties and Mixing

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Questions and Answers

Which statement correctly describes the flow characteristics of lactose?

  • Lactose exhibits a greater volume drop compared to corn starch.
  • Lactose has a high angle of repose indicating poor flow.
  • Lactose particles are too large to form cohesive bonds. (correct)
  • Lactose is hygroscopic, leading to moisture interference.

What implication does a 35% drop in volume upon tapping corn starch suggest?

  • Corn starch has good flow characteristics.
  • Corn starch particles are larger than those of lactose.
  • Corn starch is unsuitable for applications requiring high density.
  • Corn starch displays signs of cohesion. (correct)

What is indicated by an angle of repose greater than 40°?

  • The material has excellent flow.
  • The material has good powder mixing capability.
  • The material exhibits poor flow characteristics. (correct)
  • The material experiences pass flow conditions.

What does a low tapped bulk density indicate about a powder?

<p>It may not be suitable for certain applications. (D)</p> Signup and view all the answers

How is the angle of repose calculated in relation to a cone of powder?

<p>By measuring the maximum angle between the pile surface and ground. (C)</p> Signup and view all the answers

What is a significant disadvantage of convective mixers?

<p>They can lead to dead spaces with minimal powder movement. (C)</p> Signup and view all the answers

Which type of mixer is characterized by high rotational speeds and is used to mix powders with high energy input?

<p>Impaction and high shear mixers (B)</p> Signup and view all the answers

What is a key advantage of using cube, cone, and V mixers?

<p>They allow for better addition of lubricants and glidants. (D)</p> Signup and view all the answers

What potential issue is associated with the physical setup of planetary mixing?

<p>They can create adhesion problems with blades and surfaces. (C)</p> Signup and view all the answers

What distinguishes high shear mixers from other types of mixers?

<p>They significantly shatter powder particles during mixing. (A)</p> Signup and view all the answers

What characteristic of tightly packed powders results in minimal air entrapped?

<p>Maximum interparticulate contact (A)</p> Signup and view all the answers

What is the porosity percentage of loosely packed powders?

<p>48% (A)</p> Signup and view all the answers

What packing arrangement is characterized by the densest packing and a porosity of approximately 26%?

<p>Rhombohedral packing (A)</p> Signup and view all the answers

Which statement about porosity is true?

<p>It can be influenced by particle shape. (C)</p> Signup and view all the answers

What is the primary method to determine porosity in powders?

<p>Measuring the poured bulk volume without disturbance. (D)</p> Signup and view all the answers

In powder characterization, what does 'bulk density' refer to?

<p>Density of multiple particles together. (D)</p> Signup and view all the answers

What is the relationship between the 'true density' and 'particle density'?

<p>True density is always higher than particle density. (C)</p> Signup and view all the answers

Which combination of coarse and fine particles results in the densest packing arrangement?

<p>75% coarse and 25% fine (D)</p> Signup and view all the answers

What is indicated by a Carr's compressibility index greater than 33%?

<p>Poor flow characteristics (C)</p> Signup and view all the answers

What happens to the final volume during the determination of tapped density?

<p>It achieves a minimum bulk volume (C)</p> Signup and view all the answers

How does the Hausner ratio relate to powder flow properties?

<p>Values less than 1.25 usually indicate good flow (C)</p> Signup and view all the answers

What is the primary purpose of measuring tapped density?

<p>To evaluate dynamic powder packing over time (C)</p> Signup and view all the answers

What is the relationship between bulk density and tapped density?

<p>Tapped density reflects maximum packing while bulk density represents minimum packing (A)</p> Signup and view all the answers

Which factor contributes to a larger difference between poured and tapped densities?

<p>Increased interparticulate forces (A)</p> Signup and view all the answers

In powder flow characterization, what is the significance of added glidant?

<p>It can enhance flow properties if needed based on Hausner ratio (C)</p> Signup and view all the answers

What does apparent porosity represent in the context of particles?

<p>Estimated porosity that may not account for internal cracks or pores (D)</p> Signup and view all the answers

What is the primary aim of powder mixing in pharmaceutical processes?

<p>To ensure each particle from one component contacts a particle from each additional component (A)</p> Signup and view all the answers

Which mixing technique involves adding a liquid phase to powders?

<p>Wet mixing (A)</p> Signup and view all the answers

How do tumbler mixers primarily affect the mixing of powders?

<p>By causing the powders to tumble without attrition (A)</p> Signup and view all the answers

Which of the following describes the process of pre-mixing?

<p>Initial mixing of drug components with less than 5% w/w of the drug (C)</p> Signup and view all the answers

What is a key benefit of dry mixing compared to wet mixing?

<p>Dry mixing avoids introducing moisture that can affect powder properties (A)</p> Signup and view all the answers

What role does mechanical screw feeding play in powder handling?

<p>It provides a controlled flow of powders from one vessel to another (B)</p> Signup and view all the answers

Which property of the powder mixture is most affected by the mixing process?

<p>The homogeneity of drug distribution within the dosage form (B)</p> Signup and view all the answers

In the context of powder transport, what is the purpose of using a vacuum?

<p>To induce a flow of powder from one vessel to another (D)</p> Signup and view all the answers

What is the primary purpose of an impaction mixer?

<p>To break up agglomerates in dry powders (A)</p> Signup and view all the answers

What is a primary concern when selecting a mixer for powder materials?

<p>The size of the mixing vessel relative to the batch (C)</p> Signup and view all the answers

Which of the following mixing mechanisms is primarily responsible for the movement of entire groups of particles?

<p>Convection (B)</p> Signup and view all the answers

What is a potential safety hazard associated with mixing powders?

<p>Dust emissions from the powders (A)</p> Signup and view all the answers

Which type of mixer is best suited for free-flowing powders?

<p>Tumbling mixers (A)</p> Signup and view all the answers

What loading ratio is typically optimal for convective mixers?

<p>50-80% (A)</p> Signup and view all the answers

In which scenario would electrostatic charging be a significant concern during mixing?

<p>When mixing dry, fine powders (A)</p> Signup and view all the answers

What is the effect of particle size, shape, and density differences during mixing?

<p>Increased separation or segregation (B)</p> Signup and view all the answers

Flashcards

Porosity

The extent to which air spaces exist between particles in a powder. It's a measure of how much air is present in a powder sample.

Poured bulk volume

The most loosely packed state of a powder, achieved by simply pouring it into a measuring cylinder without any vibration or disturbance.

Tapped bulk volume

The densest packing state achieved by applying pressure or tapping the measuring cylinder to allow the particles to settle.

Packing Arrangement

Relates to the packing arrangement of particles in a powder. It describes how tightly the particles fit together. Cubical packing is looser, while rhombohedral packing is denser.

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Dense Packing

The densest arrangement of particles, where the particles are tightly packed together, leaving minimal air space between them. Rhombohedral packing is an example.

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Particle Density

The density of a single particle, considering its volume and weight, ignoring any internal pores or capillaries.

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Bulk Density

The density of the entire powder sample, taking into account the volume of the air spaces between the particles.

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True Density

The density of the material itself, excluding any air spaces or internal pores.

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Angle of Repose

A measure of how easily a powder flows, calculated as the angle between the surface of a heap of powder and the horizontal plane.

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Funnel Flow

A type of powder flow where particles move independently and evenly through an opening, resulting in predictable and consistent flow.

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Aspect Ratio (AR) > 1.7

Refers to elongated particles with a length-to-width ratio greater than 1.7.

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Poured Bulk Density

The density of a powder when it is packed as loosely as possible, typically measured by pouring it into a graduated cylinder without any tapping or vibration.

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Tapped Bulk Density

The density of a powder after it has been packed as tightly as possible, typically achieved by tapping or vibrating the container to allow the particles to compact.

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Tapped Density

The measured density of a powder when packed into a container and tapped until no further volume change occurs. Typically, this refers to the 'maximum bulk density' which is achieved when the powder is tapped repeatedly until a constant volume is reached.

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Carr's Compressibility Index

The ratio of the difference between tapped density and bulk density to the tapped density, expressed as a percentage. It's a measure of how much a powder can be compacted.

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Hausner Ratio

The ratio of tapped density to bulk density. It's a measure of how easily a powder flows.

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Glidant

A substance added to a powder to improve its flowability. Often used to reduce friction between particles and thus allow the powder to flow more easily.

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Density Difference

The difference between the tapped density and the bulk density of a powder. It's a direct indication of how much the powder can be compressed.

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Convective Mixer

A type of mixer where the mixing vessel is fixed, but an internal impeller moves around particles, shifting groups from one location to another within the powder bulk.

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Impaction Mixer

A mixer known for high energy input, featuring blades rotating at high speeds (2000-3000 rpm) in a static vessel. Often used to break down aggregates after other mixing processes.

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High Shear Mixing

A mixing process involving subjecting powder to very high shear forces, usually employed after convective or tumbling mixing. This process effectively breaks down aggregates and improves homogeneity.

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Nauta® Mixer

A type of mixer using a rotating impeller shaped like a 'U' to effectively move particles and blend powders.

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Tumbling Mixer

This kind of mixer features a rotating vessel, but the powder itself doesn't fall back into the mix. Instead, it uses the rotating movement to mix the powder.

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Dry mixing

A type of powder mixing where no liquid is added, aiming to mix powders without altering their properties.

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Wet mixing

Powder mixing that involves adding a liquid binder to the powder mixture, often resulting in granules.

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Pre-mixing

A preliminary mixing step for powder mixtures containing less than 5% of the active ingredient, often followed by further processing.

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Post-mixing

The final mixing step after the initial mixing, where external phases like lubricants or glidants are added to the mixture.

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Tumbler mixers

A type of mixing equipment that uses rotating vessels to tumble powders, causing them to mix by rolling over each other.

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Powder transport

The process of moving powder from one location to another, often from a hopper to a processing machine.

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Powder mixing

The method of achieving homogeneous distribution of different powder components in a mixture by bringing particles of each component into close proximity.

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Fluidized bed mixing

A mixing technique where a powder is suspended in a flowing gas stream, resulting in increased particle mobility, turbulence, and efficient mixing.

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Optimal Loading Ratio

The ratio of powder volume to the total volume of the mixing vessel, important for efficient mixing and preventing overfilling.

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Diffusion

A mixing mechanism where individual particles move randomly within the powder system, often referred to as 'micromixing'.

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Convection

A mixing mechanism where groups of particles are transferred through the powder system, often referred to as 'macromixing'.

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Shear

A mixing mechanism where layers of particles slide past each other, creating 'slip planes'.

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Segregation

The tendency for particles of different sizes, shapes, or densities to separate during mixing, resulting in an uneven mixture.

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Maintaining Adequate Mix

The process of ensuring that the mixed powder remains homogeneous during further handling and processing, preventing segregation and maintaining a consistent mixture.

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Study Notes

Preformulation - Bulk Powder Properties

  • Powders can exist in various packing states, from loosely packed (maximum airspace) to tightly packed (minimum airspace).
  • Particle size and shape influence packing density, with smaller particles filling voids between larger ones.
  • Porosity, the amount of air space between particles, is inversely related to packing density.
  • Loose packing has approximately 48% porosity, and dense packing has approximately 26% porosity.
  • Coarse and fine particles have approximately 55% porosity.

Determination of Porosity

  • Powder is placed in a measuring cylinder without vibration to determine the poured bulk volume (V₁).
  • The poured bulk density (ρ♭) is the reciprocal of the poured bulk volume.
  • The void volume (Vp) is the difference between the poured bulk volume and the particle volume.
  • Porosity is calculated by dividing the void volume by the total bulk volume.

Determination of Tapped Density

  • Powder is placed in a cylinder and tapped to determine the tapped volume (Vt).
  • The tapped density (ρt) is the reciprocal of the tapped volume.
  • Tapping increases packing density and reduces porosity.
  • This measurement is used to evaluate the dynamic powder packing characteristics.

Flow Properties

  • Interparticulate forces (e.g., Van der Waals, electrostatic) influence packing and flow.
  • Difference between poured and tapped densities indicates cohesion.
  • Increased tapping requires more energy for tighter packing.
  • Carr's compressibility index and Hausner ratio metrics predict flow properties from packing characteristics.

Hopper Design and Flow

  • Funnel flow - some powder remains stationary, while mass flow involves all powder in motion.
  • Funnel flow and rat holing are associated with shallow angle orifices and can cause segregation.
  • Mass flow is superior, and offers uniform flow with constant density.
  • Steep orifice angles minimize rat holing problems.

Flow Improvement

  • Particle size, shape, charge, and moisture influence flow.
  • Glidants are utilized to improve flow by smoothing particle surfaces.
  • Hoppers, aeration, and force feed mechanisms improve powder flow.

Powder Mixing

  • Mixing is essential to produce homogeneous distributions of powder components.
  • Components mixing variables include: particle size, shape, and density.
  • Mixing's outcome influences subsequent processes like granulation, tabletting, and capsule filling.
  • Mixing involves dry mixing (without liquid) and wet mixing (with liquid binder, such as granulation).
  • Different mixing methods (e.g., tumbler, convective, planetary) have differing efficiency for various particle types.

Interactive Powder Mixtures

  • Interactive/ordered powder mixtures result from cohesive, fine particles forming ordered units, improving homogeneity.
  • Factors like particle size and density affect segregation, while vibration and segregation (including different types) relate to stability.

Segregation as a Problem

  • Segregation is a problematic issue in powder mixtures due to particle differences in size and shape, potentially leading to uneven or non-homogenous mixtures.
  • Strategies for mitigating segregation include the careful selection of components with similar particle size and density, and/or improved mixer/process design.

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