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Questions and Answers
What is the class of mitoxantrone?
What is the class of mitoxantrone?
- Immunosuppressant (correct)
- Antibiotic
- Antitubercular
- Corticosteroid
What is the mechanism of action (MOA) of mitoxantrone?
What is the mechanism of action (MOA) of mitoxantrone?
Suppresses production of immune cells (B-cells, T-cells, macrophages)
How is mitoxantrone administered?
How is mitoxantrone administered?
IV infusion every 3 months
How is mitoxantrone metabolized?
How is mitoxantrone metabolized?
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Which of the following are adverse effects associated with mitoxantrone? (Select all that apply)
Which of the following are adverse effects associated with mitoxantrone? (Select all that apply)
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Study Notes
Mitoxantrone Overview
- Classified as an immunosuppressant, targeting the immune system to manage various conditions.
Mechanism of Action
- Suppresses the production of immune cells including B-cells, T-cells, and macrophages, reducing immune response.
Administration Protocol
- Administered via IV infusion, typically every three months for sustained effect.
Metabolism Insights
- Metabolized slowly by the liver, requiring monitoring for toxicity especially in patients with liver failure.
Adverse Effects
- Bone marrow suppression leading to increased risk of infection, necessitating precautions.
- Potential for cardiotoxicity, impacting heart function.
- Likely teratogenic effects due to its action on rapidly dividing cells, posing risks during pregnancy.
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