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Questions and Answers
Which of the following is the primary cause of the decline in mitochondrial function during ageing?
Which of the following is the primary cause of the decline in mitochondrial function during ageing?
- Progressive accumulation of somatic mutations in mtDNA (correct)
- Energy insufficiency
- Increased reactive oxygen species production
- Signalling defects
What is the consequence of impaired function of the respiratory chain?
What is the consequence of impaired function of the respiratory chain?
- Progressive accumulation of somatic mutations in mtDNA
- Increased reactive oxygen species production (correct)
- Energy insufficiency
- Signalling defects
What is the main factor responsible for the exponential increase in oxidative damage during ageing?
What is the main factor responsible for the exponential increase in oxidative damage during ageing?
- Signalling defects
- Reactive oxygen species vicious cycle (correct)
- Energy insufficiency
- Progressive accumulation of somatic mutations in mtDNA
What are the consequences of the eventual loss of cellular and tissue functions during ageing?
What are the consequences of the eventual loss of cellular and tissue functions during ageing?
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