Mitochondrial Theory of Aging
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Questions and Answers

Which of the following is the primary cause of the decline in mitochondrial function during ageing?

  • Progressive accumulation of somatic mutations in mtDNA (correct)
  • Energy insufficiency
  • Increased reactive oxygen species production
  • Signalling defects

    • What is the consequence of impaired function of the respiratory chain?

  • Progressive accumulation of somatic mutations in mtDNA
  • Increased reactive oxygen species production (correct)
  • Energy insufficiency
  • Signalling defects

    • What is the main factor responsible for the exponential increase in oxidative damage during ageing?

  • Signalling defects
  • Reactive oxygen species vicious cycle (correct)
  • Energy insufficiency
  • Progressive accumulation of somatic mutations in mtDNA

    • What are the consequences of the eventual loss of cellular and tissue functions during ageing?

    <p>Energy insufficiency, signalling defects, apoptosis</p> Signup and view all the answers

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