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Questions and Answers
What is the pharmacological class of Milrinone (Primacor)?
What is the pharmacological class of Milrinone (Primacor)?
Phosphodiesterase inhibitor
What is the therapeutic class of Milrinone (Primacor)?
What is the therapeutic class of Milrinone (Primacor)?
Inotropics - vasodilator, Pregnancy Risk Class C
What are the actions/uses of Milrinone (Primacor)?
What are the actions/uses of Milrinone (Primacor)?
Short-term treatment of heart failure, inhibits phosphodiesterase leading to increased cAMP, positive inotropic response, and vasodilation.
Are there any significant interactions with Milrinone (Primacor)?
Are there any significant interactions with Milrinone (Primacor)?
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What are the contraindications for Milrinone (Primacor)?
What are the contraindications for Milrinone (Primacor)?
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What are the administration considerations for Milrinone (Primacor)?
What are the administration considerations for Milrinone (Primacor)?
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What is the toxicity/antidote information for Milrinone (Primacor)?
What is the toxicity/antidote information for Milrinone (Primacor)?
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What are the side/adverse effects of Milrinone (Primacor)?
What are the side/adverse effects of Milrinone (Primacor)?
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What nursing considerations should be taken into account when administering Milrinone (Primacor)?
What nursing considerations should be taken into account when administering Milrinone (Primacor)?
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Study Notes
Milrinone (Primacor) Overview
- Pharmacological Class: Phosphodiesterase inhibitor
- Therapeutic Class: Inotropic agent and vasodilator; classified as Pregnancy Risk Class C
Actions and Uses
- Indicated for short-term treatment of heart failure, primarily in ICU settings
- Inhibits phosphodiesterase, increasing intracellular levels of cyclic adenosine monophosphate (cAMP)
- Enhanced cAMP leads to:
- Positive inotropic effects, improving heart contractility
- Vasodilation, reducing preload and afterload on the heart
Administration Considerations
- Available only in injectable form
- Avoid injecting furosemide into IV lines with milrinone due to immediate precipitation risk
- If significant blood pressure drop occurs, slow or stop the infusion
- Continuous monitoring of EKG is required
Toxicity and Management
- No specific antidote is available for milrinone toxicity
- Excessive doses can cause hypotension due to vasodilation; may require dosage adjustment or temporary discontinuation until stabilization
Side and Adverse Effects
- Risk of dysrhythmias, particularly ventricular types (e.g., ventricular tachycardia, ventricular fibrillation)
- Potential side effects include hypotension, angina, hypokalemia, tremor, thrombocytopenia, and elevated liver enzymes
Nursing Considerations
- Essential to monitor heart rate (HR), blood pressure (BP), EKG patterns, renal function, brain natriuretic peptide (BNP) levels, and vital signs (V/S)
- Pay attention to signs of adverse effects or toxicity, facilitating prompt response if necessary
Contraindications
- Not suitable for patients with known allergies, severe aortic or pulmonary valve disease, or heart rate issues due to diastolic dysfunction
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Description
Test your knowledge about Milrinone (Primacor) with these flashcards. This quiz covers its pharmacological class, therapeutic class, and actions/uses in clinical settings. Perfect for healthcare professionals and students in pharmacology.
