18 Questions
Transformations became routine after the development of recombinant DNA technology in 1980.
True
The first transgenic mouse was created through electroporation in 1982.
False
In 1999, the FDA approved the first DNA-antisense oligo called Formivirsen.
True
Jesse Gelsinger passed away in a gene therapy experiment in 1998.
False
In 2020, the Nobel Prize was awarded for the development of the CRISPR-Cas9 system to J. Douda and E. Charpentier.
True
Patisiran was the first mRNA vaccine approved in 2020 for COVID-19.
False
Gene therapy aims to correct existing abnormalities in cells using genetic material.
True
The 1944 Avery, MacLeod, and McCarty experiment proved that RNA causes genetic transformation.
False
Vaccine formulations typically do not involve the use of nanocarriers.
False
Restriction enzymes were discovered in 1953 by Lederberg and his team.
False
Vaccination concept and application routes are discussed in the American Society of Gene and Cell Therapy.
False
Gene delivery involves intracellular delivery of therapeutic material to manipulate genes.
True
The delivery of mRNA encoding the endonuclease is used for cutting the endonuclease mRNA.
False
The Zinc finger 3 (Z3) induced double-strand break is repaired through non-homologous end joining.
False
The DNA repair template for homologous recombination encodes the full protein.
False
Doxycycline removal leads to the termination of CAG promoter insertion by homology directed repair.
False
AAV6 and Chitosan-PLGA are used for Pulmonary Delivery of mRNA in the SPRIN-D project.
True
The SPRIN-D project is using the CRISPR/Cas13 system for genome editing.
False
Learn about important milestones in the history of gene therapy, from its introduction in the late 1970s to significant discoveries in the 1990s. Explore key events such as the development of electroporation, transformation of animals, RNAi discovery, and FDA approval of Formivirsen.
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