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Questions and Answers
Transformations became routine after the development of recombinant DNA technology in 1980.
Transformations became routine after the development of recombinant DNA technology in 1980.
True
The first transgenic mouse was created through electroporation in 1982.
The first transgenic mouse was created through electroporation in 1982.
False
In 1999, the FDA approved the first DNA-antisense oligo called Formivirsen.
In 1999, the FDA approved the first DNA-antisense oligo called Formivirsen.
True
Jesse Gelsinger passed away in a gene therapy experiment in 1998.
Jesse Gelsinger passed away in a gene therapy experiment in 1998.
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In 2020, the Nobel Prize was awarded for the development of the CRISPR-Cas9 system to J. Douda and E. Charpentier.
In 2020, the Nobel Prize was awarded for the development of the CRISPR-Cas9 system to J. Douda and E. Charpentier.
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Patisiran was the first mRNA vaccine approved in 2020 for COVID-19.
Patisiran was the first mRNA vaccine approved in 2020 for COVID-19.
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Gene therapy aims to correct existing abnormalities in cells using genetic material.
Gene therapy aims to correct existing abnormalities in cells using genetic material.
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The 1944 Avery, MacLeod, and McCarty experiment proved that RNA causes genetic transformation.
The 1944 Avery, MacLeod, and McCarty experiment proved that RNA causes genetic transformation.
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Vaccine formulations typically do not involve the use of nanocarriers.
Vaccine formulations typically do not involve the use of nanocarriers.
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Restriction enzymes were discovered in 1953 by Lederberg and his team.
Restriction enzymes were discovered in 1953 by Lederberg and his team.
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Vaccination concept and application routes are discussed in the American Society of Gene and Cell Therapy.
Vaccination concept and application routes are discussed in the American Society of Gene and Cell Therapy.
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Gene delivery involves intracellular delivery of therapeutic material to manipulate genes.
Gene delivery involves intracellular delivery of therapeutic material to manipulate genes.
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The delivery of mRNA encoding the endonuclease is used for cutting the endonuclease mRNA.
The delivery of mRNA encoding the endonuclease is used for cutting the endonuclease mRNA.
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The Zinc finger 3 (Z3) induced double-strand break is repaired through non-homologous end joining.
The Zinc finger 3 (Z3) induced double-strand break is repaired through non-homologous end joining.
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The DNA repair template for homologous recombination encodes the full protein.
The DNA repair template for homologous recombination encodes the full protein.
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Doxycycline removal leads to the termination of CAG promoter insertion by homology directed repair.
Doxycycline removal leads to the termination of CAG promoter insertion by homology directed repair.
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AAV6 and Chitosan-PLGA are used for Pulmonary Delivery of mRNA in the SPRIN-D project.
AAV6 and Chitosan-PLGA are used for Pulmonary Delivery of mRNA in the SPRIN-D project.
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The SPRIN-D project is using the CRISPR/Cas13 system for genome editing.
The SPRIN-D project is using the CRISPR/Cas13 system for genome editing.
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