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Questions and Answers
What is the brand name for Midazolam?
What classification does Midazolam fall under?
Amnesic Agent, Sedative/Hypnotic, Anticonvulsant, Benzodiazepine, Anti-anxiety
The MOA of Versed involves binding to __________.
Benzodiazepine receptors
Which of the following are indications for Versed?
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What is NOT a contraindication for Versed?
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Name two common side effects of Versed.
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Which patients require precautions when using Versed?
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What should be avoided when administering Versed?
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What are the routes of administration for Versed?
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What is the onset time for Versed when administered IVP?
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What is the initial dosage of Versed for adult pre-cardioversion?
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Study Notes
Midazolam Overview
- Brand Name: Versed
- Classification:
- Amnesic Agent
- Sedative/Hypnotic
- Anticonvulsant
- Benzodiazepine
- Anti-anxiety
Mechanism of Action
- Binds to benzodiazepine receptors
- Enhances GABA, leading to:
- Decreased agitation
- Muscle relaxation
- Induction of sleep at high doses
Indications
- Treatment of seizures
- Premedication for synchronized cardioversion/transcutaneous pacing (TCP)
- One of the options for Rapid Sequence Intubation (RSI) premedication
- Management of anxiety disorders
Contraindications
- Not to be used in acute narrow-angle glaucoma
- Should be avoided in shock due to hypovolemia
- Contraindicated in cases of alcohol or drug intoxication
Side Effects
- Cardiovascular:
- Bradycardia
- Hypotension
- Rebound tachycardia
- Neurological:
- Amnesia
- Drowsiness
- Agitation
- Altered Level of Consciousness (ALOC)
- Respiratory:
- Potential respiratory depression or arrest
- Gastrointestinal:
- Nausea and vomiting (N/V)
Precautions
- Caution in elderly patients with impaired respiratory function
- Use carefully in patients with:
- Renal failure
- Liver failure
- Chronic Obstructive Pulmonary Disease (COPD)
Drug Interactions
- Enhanced effects when combined with other CNS depressants or benzodiazepines
Routes of Administration
- Administered via:
- IV Push (IVP)
- Intraosseous (IO)
- Intramuscular (IM)
- Intranasal (IN)
Onset and Duration
- Rapid onset:
- 1-5 minutes via IVP/IO/IN
- 5-15 minutes via IM
- Duration of effect is approximately 2-6 hours
Dosages
-
Adult:
- Pre-cardioversion or TCP: 1.0 - 2.5 mg slow IVP/IO/IN
- For seizures: 0.1 mg/kg slow IVP/IO/IN or 0.2 mg/kg IM, max 5 mg
-
Pediatric:
- For seizures: 0.1 mg/kg slow IVP/IO/IN or 0.2 mg/kg IM, max 5 mg
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Description
Test your knowledge on Midazolam, also known as Versed, through these flashcards. Learn about its classification, mechanism of action, and indications in a fun and interactive way. Perfect for students and professionals in the medical field!