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Questions and Answers
What is the generic name of Microzide?
What is the generic name of Microzide?
What drug class does Microzide belong to?
What drug class does Microzide belong to?
Diuretic
What are the dosage forms of Microzide?
What are the dosage forms of Microzide?
Capsules: 12.5 mg; Tablets: 12.5, 25, 50 mg
What are the indications for using Microzide?
What are the indications for using Microzide?
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What is the normal starting dose of Microzide?
What is the normal starting dose of Microzide?
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What is the recommended dosing for hypertension control with Microzide?
What is the recommended dosing for hypertension control with Microzide?
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What is the dosing recommendation for children taking Microzide?
What is the dosing recommendation for children taking Microzide?
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What is Microzide's mechanism of action?
What is Microzide's mechanism of action?
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How long does it take for Microzide to reach peak plasma levels?
How long does it take for Microzide to reach peak plasma levels?
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What is the half-life of Microzide?
What is the half-life of Microzide?
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What are the potential drug interactions when taking Microzide?
What are the potential drug interactions when taking Microzide?
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What are the contraindications and precautions for using Microzide?
What are the contraindications and precautions for using Microzide?
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What are the common adverse effects of Microzide?
What are the common adverse effects of Microzide?
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What patient consultation advice should be given when prescribing Microzide?
What patient consultation advice should be given when prescribing Microzide?
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Study Notes
Microzide Overview
- Generic name is Hydrochlorothiazide, classified as a diuretic.
- Available in capsule (12.5 mg) and tablet forms (12.5 mg, 25 mg, 50 mg).
Indications
- Used to treat edema related to congestive heart failure, hepatic cirrhosis, corticosteroid and estrogen therapy, and renal dysfunction.
- Effective for controlling hypertension.
Dosage Information
- Normal starting dose ranges from 25-100 mg daily, either as a single or divided oral dose.
- For hypertension management, usually prescribed at 25 mg daily, though some patients may need up to 50 mg in divided doses.
- Pediatric dosing involves 1-2 mg/kg/day, with infants under 6 months allowed up to 3 mg/kg/day in two divided doses.
Pharmacokinetics
- Peak plasma levels occur approximately 4 hours after administration.
- Half-life of the drug ranges from 6 to 15 hours.
Mechanism of Action
- Functions by inhibiting the reabsorption of sodium and chloride in the distal renal tubule.
Drug Interactions
- May reduce the hypoglycemic effects of sulfonylureas.
- Electrolyte imbalances can lead to digitalis-induced arrhythmias.
- Diazide can induce hyperglycemia.
- Can increase serum lithium levels.
Contraindications and Precautions
- Contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs.
- Caution advised for those with cirrhosis, gout, renal or hepatic impairment, diabetes, and those on corticosteroids or ACTH.
- Classified as pregnancy category B.
Adverse Effects
- Possible side effects include dry mouth, muscle cramps, nausea, vomiting, anemia, weakness, dizziness, hypotension, anorexia, gastrointestinal distress, hyperglycemia, photosensitivity, rash, and transient blurred vision.
Patient Consultation
- Can be taken with food or milk if GI upset occurs.
- Importance of timing; best taken in the early morning to mitigate increased diuresis.
- Advise against excessive sun exposure.
- Store medication in a cool, dry place.
- Patients should contact their physician if persistent side effects arise.
- If a dose is missed, skip it and continue with the regular schedule.
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Test your knowledge of Microzide with these flashcards. Learn about its generic name, drug class, dosage forms, and indications. Perfect for students and professionals in the medical field.