Microtubule Dynamics and Anaphase Processes
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Questions and Answers

What is the main function of anaphase B in mitosis?

  • Activation of APC
  • Movement of spindle poles apart (correct)
  • Anchoring of dynein on cell cortex
  • Shortening of kinetochore microtubules

What is the role of securin in mitosis?

  • Moving spindle poles apart
  • Activating the APC
  • Inhibiting separase (correct)
  • Shortening kinetochore microtubules

How does the spindle assessment checkpoint control mitosis?

  • By moving spindle poles apart
  • By activating APC
  • By inhibiting APC (correct)
  • By dephosphorylating nuclear pore proteins

During telophase, what happens to nuclear pore proteins and nuclear lamins?

<p>They dephosphorylate (C)</p> Signup and view all the answers

What initiates cleavage furrow formation during cytokinesis?

<p>Central spindle signaling cell cortex (D)</p> Signup and view all the answers

What is the primary role of dynein in mitosis?

<p>Moving spindle poles apart (D)</p> Signup and view all the answers

What is the role of tethering proteins in vesicle trafficking?

<p>Assist in firmly docking the vesicle before fusion (D)</p> Signup and view all the answers

In the secretory pathway, what is the destination after Golgi apparatus for proteins before exocytosis?

<p>Plasma membrane (A)</p> Signup and view all the answers

Which organelle is responsible for sorting and packaging proteins destined for regulated secretion?

<p>Trans Golgi network (B)</p> Signup and view all the answers

What triggers apoptosis in response to protein misfolding in the ER?

<p>Unfolded protein response (C)</p> Signup and view all the answers

What is a characteristic feature of late endosomes compared to early endosomes?

<p>They are closer to the nucleus (D)</p> Signup and view all the answers

Which type of endocytosis involves clathrin-coated pits and vesicles?

<p>Receptor-mediated endocytosis (A)</p> Signup and view all the answers

What distinguishes the constitutive exocytosis pathway from the regulated exocytosis pathway?

<p>The requirement of a signal sequence (D)</p> Signup and view all the answers

What occurs when Cdc6 binds to the origin recognition complex (ORC) during the G1 phase of the cell cycle?

<p>Promotes assembly of proteins for replication fork formation (D)</p> Signup and view all the answers

What is the function of Cdc25 in the cell cycle control system?

<p>Removes inhibitory phosphate from M-Cdk (B)</p> Signup and view all the answers

What triggers the breakdown of the nuclear envelope in prometaphase of mitosis?

<p>Phosphorylation of nuclear pore proteins (A)</p> Signup and view all the answers

What is the role of cohesin proteins during mitosis?

<p>Holds sister chromatids together (C)</p> Signup and view all the answers

What effect does the accumulation of cyclins have on the cell cycle?

<p>Delays entry into M phase (A)</p> Signup and view all the answers

Which protein is responsible for activating transcription regulators important for initiating gene transcription in the cell cycle?

<p>Rb protein (C)</p> Signup and view all the answers

What happens when S-Cdk is activated during the S phase of the cell cycle?

<p>Blocks re-replication of DNA (B)</p> Signup and view all the answers

"Wee1" is involved in regulating which phase of the cell cycle?

<p>&quot;M Phase&quot; (C)</p> Signup and view all the answers

"Anaphase-promoting complex (APC)" is responsible for which crucial function during mitosis?

<p>&quot;Tagging cyclins with ubiquitin&quot; (A)</p> Signup and view all the answers

"Mitogens" promote the production of which cyclins that stimulate cell division?

<p>&quot;G1 Cyclins&quot; (A)</p> Signup and view all the answers

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