Podcast
Questions and Answers
What is the general shape of an antibody protein structure?
What is the general shape of an antibody protein structure?
- Y-shaped (correct)
- Triangular
- Linear
- Circular
What type of bonds stabilize the antibody chains?
What type of bonds stabilize the antibody chains?
- Disulphide bonds (correct)
- Peptide bonds
- Hydrogen bonds
- Ionic bonds
How many variable domains are present in a light chain?
How many variable domains are present in a light chain?
- Four
- Two
- One (correct)
- Three
What is the main function of the Fc region?
What is the main function of the Fc region?
What is the smallest part of an antibody that maintains antigen binding affinity?
What is the smallest part of an antibody that maintains antigen binding affinity?
What do the heavy chains of an antibody consist of?
What do the heavy chains of an antibody consist of?
What determines the antibody specificity to bind antigen?
What determines the antibody specificity to bind antigen?
How are the five classes of antibodies classified?
How are the five classes of antibodies classified?
What is the name of the heavy chain in IgG antibodies?
What is the name of the heavy chain in IgG antibodies?
How are the subclasses of antibodies further divided?
How are the subclasses of antibodies further divided?
What are the two types of light chains found in antibodies?
What are the two types of light chains found in antibodies?
What technique is used to generate murine monoclonal antibodies?
What technique is used to generate murine monoclonal antibodies?
What is the primary reason for generating chimeric monoclonal antibodies?
What is the primary reason for generating chimeric monoclonal antibodies?
What is the key difference between chimeric and humanized monoclonal antibodies?
What is the key difference between chimeric and humanized monoclonal antibodies?
What is the primary function of phage display technology in antibody production?
What is the primary function of phage display technology in antibody production?
What is the significance of using transgenic mouse strains in antibody production?
What is the significance of using transgenic mouse strains in antibody production?
What is the primary advantage of humanized and fully human antibodies over chimeric antibodies?
What is the primary advantage of humanized and fully human antibodies over chimeric antibodies?
What is the characteristic of humanized and fully human antibodies that is similar to human endogenous IgGs?
What is the characteristic of humanized and fully human antibodies that is similar to human endogenous IgGs?
What is the characteristic of monoclonal antibodies?
What is the characteristic of monoclonal antibodies?
What is the limitation of naked antibody molecules in cancer therapy?
What is the limitation of naked antibody molecules in cancer therapy?
What is the optimal characteristic of an antibody for efficacious therapy?
What is the optimal characteristic of an antibody for efficacious therapy?
What is the difference between monoclonal and polyclonal antibodies?
What is the difference between monoclonal and polyclonal antibodies?
What is the advantage of linking antibody molecules to cytotoxic drugs, toxins, or radionuclides?
What is the advantage of linking antibody molecules to cytotoxic drugs, toxins, or radionuclides?
What type of antibodies are expressed in transgenic mice?
What type of antibodies are expressed in transgenic mice?
What is a key factor to consider in Ab-based therapy design?
What is a key factor to consider in Ab-based therapy design?
What is the main difference between a chimeric antibody and a humanized antibody?
What is the main difference between a chimeric antibody and a humanized antibody?
Which type of antibody is entirely of human origin?
Which type of antibody is entirely of human origin?
What is the purpose of considering the isotype of the mAb in Ab-based therapy design?
What is the purpose of considering the isotype of the mAb in Ab-based therapy design?
What is a characteristic of a murine antibody?
What is a characteristic of a murine antibody?
What is the purpose of grafting a murine CDR region onto a human variable region in humanized antibody production?
What is the purpose of grafting a murine CDR region onto a human variable region in humanized antibody production?
What is the primary mechanism by which antibody-dependent cytotoxicity (ADCC) eliminates targeted cells?
What is the primary mechanism by which antibody-dependent cytotoxicity (ADCC) eliminates targeted cells?
What is the main difference between a humanized antibody and a fully human antibody?
What is the main difference between a humanized antibody and a fully human antibody?
What is the primary advantage of using chimeric antibodies over murine antibodies in Ab-based therapy?
What is the primary advantage of using chimeric antibodies over murine antibodies in Ab-based therapy?
What is the primary function of the constant region in an antibody?
What is the primary function of the constant region in an antibody?
What is the primary mechanism by which complement-dependent cytotoxicity (CDC) eliminates targeted cells?
What is the primary mechanism by which complement-dependent cytotoxicity (CDC) eliminates targeted cells?
What is the primary characteristic of a murine antibody that makes it less suitable for human therapy?
What is the primary characteristic of a murine antibody that makes it less suitable for human therapy?
What is the primary advantage of using fully human antibodies over humanized antibodies in Ab-based therapy?
What is the primary advantage of using fully human antibodies over humanized antibodies in Ab-based therapy?
What is the primary function of the variable region in an antibody?
What is the primary function of the variable region in an antibody?
What is the primary mechanism by which naked antibody molecules induce cell death in cancer therapy?
What is the primary mechanism by which naked antibody molecules induce cell death in cancer therapy?
What is the primary characteristic of an antibody that determines its ability to induce antibody-dependent cellular cytotoxicity (ADCC)?
What is the primary characteristic of an antibody that determines its ability to induce antibody-dependent cellular cytotoxicity (ADCC)?
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