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Microbiology and Infections

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Questions and Answers

What is the primary function of PhI?

To catalyze the degradation of Streptomyces peptides

To facilitate the synthesis of cephalosporin antibiotics

To regulate the expression of anti-microbial genes (correct)

To inhibit the activity of aflatoxin-inducing enzymes

What is the primary source of the Streptomyces genome?

Fermentation broth

Sporulating bacteria

Actinobacterial genus (correct)

Fungal pathogens

What is the role of anti-microbial genes in Streptomyces?

To induce the production of antibiotics (correct)

To regulate the expression of virulence factors

To protect against fungal invasion

To enhance the potency of toxins

What is the effect of Aflatoxin-inducing enzymes on Streptomyces?

<p>Inhibits the expression of anti-microbial genes</p> Signup and view all the answers

What is the role of Phaferome in Streptomyces?

<p>Facilitates the synthesis of cephalosporin antibiotics</p> Signup and view all the answers

Study Notes

Promicrosome Components

Composed of Pro-Organelle (U) and Antipenicillmic Ribosome (Strep)

Cephalosporin Synthesis

Involves actinomycete species (Strep)
Requires PhaF (Pharmaceutical I) and PhI (Pharmaceutical II) enzymes
PhI catalyzes the formation of a β-lactam ring

β-Lactam Ring Formation

Mediated by PhI enzyme
Involves a non-ribosomal peptide synthesis (NRPS) pathway
PhI generates a β-lactam ring from a dipeptide precursor

Streptomyces Cullinanea

Produces cephalosporin antibiotics
Involves Med-A (Mediator A) and PhI enzymes
Med-A is a central mediator in the cephalosporin biosynthetic pathway

Cephalosporin Biosynthesis

Involves the conversion of a linear tripeptide into a cyclic β-lactam compound
Requires a series of enzyme-catalyzed reactions
Results in the formation of a β-lactam ring, a characteristic feature of cephalosporin antibiotics

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Description

This quiz assesses knowledge of microbiology, including bacteria, antibiotics, and infections. It covers various types of microorganisms and their effects on the human body.