5 Questions
What is the primary function of PhI?
To regulate the expression of anti-microbial genes
What is the primary source of the Streptomyces genome?
Actinobacterial genus
What is the role of anti-microbial genes in Streptomyces?
To induce the production of antibiotics
What is the effect of Aflatoxin-inducing enzymes on Streptomyces?
Inhibits the expression of anti-microbial genes
What is the role of Phaferome in Streptomyces?
Facilitates the synthesis of cephalosporin antibiotics
Study Notes
Promicrosome Components
- Composed of Pro-Organelle (U) and Antipenicillmic Ribosome (Strep)
Cephalosporin Synthesis
- Involves actinomycete species (Strep)
- Requires PhaF (Pharmaceutical I) and PhI (Pharmaceutical II) enzymes
- PhI catalyzes the formation of a β-lactam ring
β-Lactam Ring Formation
- Mediated by PhI enzyme
- Involves a non-ribosomal peptide synthesis (NRPS) pathway
- PhI generates a β-lactam ring from a dipeptide precursor
Streptomyces Cullinanea
- Produces cephalosporin antibiotics
- Involves Med-A (Mediator A) and PhI enzymes
- Med-A is a central mediator in the cephalosporin biosynthetic pathway
Cephalosporin Biosynthesis
- Involves the conversion of a linear tripeptide into a cyclic β-lactam compound
- Requires a series of enzyme-catalyzed reactions
- Results in the formation of a β-lactam ring, a characteristic feature of cephalosporin antibiotics
This quiz assesses knowledge of microbiology, including bacteria, antibiotics, and infections. It covers various types of microorganisms and their effects on the human body.
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