Microbial Cross-Resistance Quiz
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Questions and Answers

What is the first-line prophylaxis therapy for acute or recurrent urinary tract infections?

  • Nitrofurantoin (correct)
  • Nifuroxazide
  • Nitrofurazone
  • Furazolidone
  • Which drug is used to treat enteric infections in small animals?

  • Nifuroxazide
  • Nitrofurantoin
  • Furazolidone (correct)
  • Nitrofurazone
  • Which drug was discovered to cause ovarian and mammary tumors in non-food animals?

  • Nifuroxazide
  • Nitrofurazone (correct)
  • Furazolidone
  • Nitrofurantoin
  • Which of the following drugs is banned for use in food animals in the EU, USA, and Canada?

    <p>Ronidazole</p> Signup and view all the answers

    Which drug is considered first-line prophylaxis therapy for urinary tract infections but has little to no activity against Proteus and none whatsoever against Pseudomonas?

    <p>Nitrofurantoin</p> Signup and view all the answers

    What is the mechanism by which nitrofurazone causes ovarian and mammary tumors in non-food animals?

    <p>By inducing oxidative DNA damage through its metabolites</p> Signup and view all the answers

    Which of the following drugs is NOT absorbed from the gastrointestinal tract?

    <p>Furazolidone</p> Signup and view all the answers

    Which class of drugs have antimicrobial activity against both anaerobic bacteria and protozoa?

    <p>Nitroimidazoles</p> Signup and view all the answers

    Which drug is first-line prophylaxis therapy for urinary tract infections but has little to no activity against Proteus and none whatsoever against Pseudomonas?

    <p>Nitrofurantoin</p> Signup and view all the answers

    Which drugs are banned for use in food animals in the EU, USA, and Canada?

    <p>Nitrofurantoin and nitrofurazone</p> Signup and view all the answers

    Which of the following breeds is predisposed to hypersensitivity due to their reduced ability to detoxify hydroxylamine groups?

    <p>German shepherd</p> Signup and view all the answers

    What condition can occur due to prolonged use of some sulfonamides?

    <p>Keratoconjunctivitis sicca (KCS)</p> Signup and view all the answers

    Which drug combination is known as potentiated sulfonamide?

    <p>Sulfonamide + folic acid antimetabolite</p> Signup and view all the answers

    Which type of reaction in dogs occurs due to hydroxylamine metabolite?

    <p>Hepatitis</p> Signup and view all the answers

    What is the cytotoxic metabolite formed by oxidation that can lead to hypersensitivity reactions in dogs?

    <p>Hydroxylamine</p> Signup and view all the answers

    Which GI disturbance can be caused by sulfonamides?

    <p>Photosensitivity</p> Signup and view all the answers

    What can occur due to the prolonged use of sulfasalazine for the treatment of ulcerative colitis?

    <p>Keratoconjunctivitis sicca (KCS)</p> Signup and view all the answers

    What is the cytotoxic metabolite formed by oxidation that can lead to hypersensitivity reactions in dogs?

    <p>Hydroxylamine</p> Signup and view all the answers

    Which breeds are predisposed to hypersensitivity due to their reduced ability to detoxify hydroxylamine groups?

    <p>Dobermanns and Pinschers</p> Signup and view all the answers

    What can occur due to prolonged use of sulfasalazine for the treatment of ulcerative colitis?

    <p>KCS (Keratoconjunctivitis Sicca)</p> Signup and view all the answers

    Which drugs are banned for use in food animals in the EU, USA, and Canada due to their potential to cause ovarian and mammary tumors?

    <p>Folic acid and Nitrofurazone</p> Signup and view all the answers

    Which drug, when used in conjunction with antimetabolites of the folic group, achieves an extra-powerful effect due to potentiation?

    <p>Sulfasalazine</p> Signup and view all the answers

    What do sulphonamides work in conjunction with in order to achieve an extra-powerful effect?

    <p>Antimetabolites of the folic group</p> Signup and view all the answers

    Which condition can occur due to prolonged use of some sulfonamides?

    <p>Photosensitivity</p> Signup and view all the answers

    What type of reaction in dogs occurs due to hydroxylamine metabolite?

    <p>Polyarthritis</p> Signup and view all the answers

    What is the mechanism by which potentiated sulfonamide achieves an extra-powerful effect?

    <p>Combining with antimetabolites of the folic group</p> Signup and view all the answers

    Which class of drugs have antimicrobial activity against both anaerobic bacteria and protozoa?

    <p>Sulfonamides</p> Signup and view all the answers

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