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Questions and Answers
What condition is mexiletine primarily indicated for?
What should be monitored due to the risk of adverse effects when using mexiletine?
Which of the following is a contraindication for the use of mexiletine?
What is a critical precaution when prescribing mexiletine?
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What is a potential interaction concern when administering mexiletine?
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What is a significant consideration when prescribing mexiletine to patients with hepatic disease?
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What common side effect might a patient experience while taking mexiletine?
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Which of the following is a serious adverse effect associated with mexiletine?
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What should patients be advised regarding the administration of mexiletine to minimize gastrointestinal side effects?
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What type of patients is mexiletine indicated for based on its black box warning (BBW)?
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Study Notes
Mexiletine
- Mexiletine is a medication used to treat life-threatening ventricular arrhythmias.
- It is resistant to first-pass metabolism, meaning it is absorbed well into the bloodstream.
- Dose reduction may be required in patients with severe hepatic disease.
- A Black Box Warning (BBW) is in place for Mexiletine. This warning advises its use only in patients with life-threatening ventricular dysrhythmias due to an increased risk of mortality.
- Contraindications include sensitivity to local anesthetics and patients with second or third-degree heart block.
- Common side effects include nausea, vomiting, and central nervous system (CNS) symptoms like dizziness, headache, lightheadedness, numbness, blurred vision, slurred speech, and paresthesia.
- Serious side effects include changes in the QRS duration of an electrocardiogram (ECG) and seizures.
- Mexiletine interacts with CYP1A2 and 2D6 inhibitors.
- It can also increase theophylline levels in the body.
- Taking Mexiletine with food can help reduce gastrointestinal side effects.
Mexiletine
- Mexiletine is a medication used to treat life-threatening ventricular arrhythmias.
- It is resistant to first-pass metabolism, meaning a large portion of the drug reaches systemic circulation.
- Mexiletine is metabolized in the liver, so dose reduction may be required in patients with severe hepatic disease.
- Mexiletine has a black box warning due to increased mortality risk.
- It is contraindicated in patients with sensitivity to local anesthetics or those with second or third-degree heart block.
- Monitor QRS duration during treatment.
- Common side effects include nausea, vomiting, dizziness, headache, lightheadedness, numbness, blurred vision, slurred speech, and paresthesia.
- Serious side effects include QRS widening and seizures.
- Mexiletine interacts with CYP1A2 and 2D6 inhibitors.
- It can also increase theophylline levels.
- Taking Mexiletine with food can help reduce gastrointestinal side effects.
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Description
This quiz covers key information about Mexiletine, a medication used to treat serious ventricular arrhythmias. It discusses its pharmacokinetics, contraindications, side effects, and important warnings related to its use. Ideal for those studying pharmacology or medicine.
