Podcast
Questions and Answers
What classification does Metoprolol belong to?
What classification does Metoprolol belong to?
What is the action of Metoprolol?
What is the action of Metoprolol?
Blocks stimulation to beta1-adrenergic receptors without usually affecting beta2-adrenergic receptors.
What are the therapeutic effects of Metoprolol?
What are the therapeutic effects of Metoprolol?
Decreases BP, heart rate, angina, and controlled congestive heart failure.
What are Beta1 adrenergic receptors associated with?
What are Beta1 adrenergic receptors associated with?
Signup and view all the answers
What are the primary locations of beta2 adrenergic receptors?
What are the primary locations of beta2 adrenergic receptors?
Signup and view all the answers
With what can Metoprolol be used?
With what can Metoprolol be used?
Signup and view all the answers
How is Metoprolol absorbed?
How is Metoprolol absorbed?
Signup and view all the answers
Where is Metoprolol metabolized?
Where is Metoprolol metabolized?
Signup and view all the answers
How is Metoprolol excreted from the body?
How is Metoprolol excreted from the body?
Signup and view all the answers
What factors affect the onset and duration of Metoprolol?
What factors affect the onset and duration of Metoprolol?
Signup and view all the answers
What routes are available for Metoprolol administration?
What routes are available for Metoprolol administration?
Signup and view all the answers
What will Metoprolol do in terms of distribution in the body?
What will Metoprolol do in terms of distribution in the body?
Signup and view all the answers
What are some contraindications/cautions for Metoprolol?
What are some contraindications/cautions for Metoprolol?
Signup and view all the answers
What are some common side effects of Metoprolol?
What are some common side effects of Metoprolol?
Signup and view all the answers
What are some adverse reactions of Metoprolol?
What are some adverse reactions of Metoprolol?
Signup and view all the answers
Which medications should be monitored for interactions with Metoprolol?
Which medications should be monitored for interactions with Metoprolol?
Signup and view all the answers
What is the maximum dose of Metoprolol?
What is the maximum dose of Metoprolol?
Signup and view all the answers
What assessments should be done when administering Metoprolol?
What assessments should be done when administering Metoprolol?
Signup and view all the answers
Study Notes
Classification of Metoprolol
- A beta-adrenergic antagonist; classified as a beta-blocker antihypertensive.
Mechanism of Action
- Primarily blocks beta1-adrenergic receptors, minimal impact on beta2-adrenergic receptors.
- Reduces sympathetic nervous system effects, leading to a slower heart rate and decreased cardiac force.
- Results in lower cardiac output and blood pressure.
Therapeutic Effects
- Effective in lowering blood pressure and heart rate.
- Alleviates angina and helps to manage controlled congestive heart failure.
Beta1 Adrenergic Receptors
- Located in the myocardium, these receptors primarily influence heart function.
Beta2 Adrenergic Receptors
- Found in pulmonary, vascular, and uterine tissues, involved in various physiological responses.
Compatible Medications
- Can be safely combined with ACE inhibitors, diuretics, digoxin, and Toprol XL.
Absorption
- Metoprolol is well absorbed following oral administration.
Metabolism
- Primarily metabolized by the liver.
Excretion
- Excreted via breast milk and urine.
Onset and Duration
- The onset of effects and duration of action vary with the route of administration.
Administration Routes
- Available in oral (PO) and intravenous (IV) forms.
Distribution
- Crosses blood-brain barrier (BBB), placenta, and is present in breast milk.
Contraindications and Cautions
- Not recommended for patients with severe bradycardia, cardiogenic shock, heart failure, or respiratory distress.
Side Effects
- Common side effects include fatigue, dizziness, erectile dysfunction, depression, diarrhea, and hypoglycemia.
Adverse Reactions
- Severe adverse outcomes can include bradycardia, heart failure, pulmonary edema, AV block, and rebound hypertension upon abrupt cessation.
Drug Interactions
- Increased bradycardia when used with diltiazem; reduced metoprolol effectiveness with certain antidepressants.
- Interacts with ethanol (alcohol).
Max Dose
- Information on the maximum dosage is not provided.
Assessments
- Important to check apical and peripheral pulse. Significant monitoring if heart rate falls below certain thresholds.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Explore essential pharmacology concepts associated with Metoprolol, a beta-adrenergic antagonist. This quiz provides detailed flashcards on its classification, actions, and effects on the cardiovascular system. Test your knowledge on how this medication influences heart rate and blood pressure.
