Questions and Answers
What is the mechanism of action (MOA) of Methenamine?
Must be converted to formaldehyde in the urine to be active
What pathogens does Methenamine cover?
All urinary tract pathogens
What are some adverse reactions associated with Methenamine?
GI; intestinal distress, Skin; rashes
What should you give with Methenamine to further acidify urine?
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What is the usual use of Methenamine rather than treating UTIs?
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Methenamine is NOT effective for prevention of UTIs in which patients?
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Methenamine causes a drug interaction with which drug class, and what is the outcome?
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What is the recommended dosage for Methenamine hippurate (Hiprex, Urex)?
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What is the recommended dosage for Methenamine mandelate (Mandelamine)?
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Study Notes
Methenamine Overview
- Methenamine requires conversion to formaldehyde in urine for activation.
- Effective against all pathogens causing urinary tract infections (UTIs).
Adverse Reactions
- Gastrointestinal issues may arise, including intestinal distress.
- Skin reactions, such as rashes, can occur.
Urinary Acidification
- Vitamin C is recommended to further acidify urine when using methenamine.
Preventive Use
- Primarily used to prevent recurrent UTIs rather than to treat existing infections.
Patient Limitations
- Ineffective for UTI prevention in patients with foley catheters or those undergoing intermittent catheterization.
Drug Interactions
- Methenamine interacts with sulfonamides, leading to an increased risk of crystalluria.
Dosage Information
- Methenamine hippurate (Hiprex, Urex): 500mg to 1000mg twice daily (BID).
- Methenamine mandelate (Mandelamine): 1000mg four times daily (QID).
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Description
Test your knowledge of methenamine with these flashcards. These cards cover its mechanism of action, pathogen coverage, adverse reactions, and tips for urine acidification. Perfect for students and professionals in pharmacology.
