Metaxalone Overview and Uses

What is the brand name of Metaxalone?

What drug class does Metaxalone belong to?

What are the routes of administration for Metaxalone?

What is the common FDA indication for Metaxalone?

What is the typical dosing for Metaxalone?

What is known about the mechanism of action of Metaxalone?

Renal dose adjustment is not required for Metaxalone.

Which of the following are contraindications for Metaxalone?

Are there any boxed warnings for Metaxalone?

What types of agents interact with Metaxalone?

What is a common adverse reaction to Metaxalone?

Rare but serious adverse reactions of Metaxalone include ________.

What are the efficacy monitoring parameters for Metaxalone?

What are the toxicity monitoring parameters for Metaxalone?

Metaxalone Overview

Brand name for Metaxalone is Skelaxin.
Classified as a centrally acting skeletal muscle relaxant.

Administration and Dosage

Available in oral tablet form: 400 mg and 800 mg dosages.
Common dosing regimen is 800 mg by mouth 3 to 4 times daily.

Indications and Uses

Primarily indicated for the treatment of musculoskeletal pain or spasms.

Mechanism of Action

Mechanism has not been fully established but may involve general central nervous system depression.
Does not have a direct effect on striated muscle’s contractile mechanisms or nerve fibers.

Considerations for Use

Renal dose adjustments are necessary; start with lower initial doses and increase carefully.
Contraindicated in individuals with hypersensitivity or significantly impaired renal or hepatic function.

Safety Information

There are no boxed warnings associated with Metaxalone.
Be cautious of drug interactions with CNS depressants (e.g., opioids, benzodiazepines, alcohol) due to additive sedative effects; monitor for toxicity signs.

Adverse Reactions

Common adverse reaction includes dizziness.
Rare but serious reactions can occur, such as hemolytic anemia, leukopenia, jaundice, immune hypersensitivity, maculopapular rash, and respiratory issues when combined with opioids.

Monitoring Parameters

Efficacy monitored by reduction in pain and muscle spasms.
Toxicity should be monitored by periodic checks of liver function tests (LFTs) and complete blood count (CBC).

This quiz covers important information about Metaxalone, including its classification, administration, dosage, indications, and mechanism of action. Understand key safety considerations and the proper use of this muscle relaxant to manage musculoskeletal pain effectively.