pathophysiology test 4 review
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Questions and Answers

Which process involves synthesizing macromolecules from building blocks?

  • Catabolism
  • Anabolism (correct)
  • Metabolism
  • Photosynthesis

What is the primary function of stage 1 in the Anabolism of food?

  • Activation of precursors
  • Production of precursors (correct)
  • Feed into the Citric Acid Cycle
  • Assembly of macromolecules

Which type of reaction requires energy from ATP for the activation of precursors?

  • Catabolic reactions
  • Photosynthesis
  • Metabolic reactions
  • Anabolic reactions (correct)

What is the major source of calories in a typical diet according to the text?

<p>Carbohydrates (C)</p> Signup and view all the answers

Which stage involves converting all basic monomers to Acetyl CoA in the Catabolism of food?

<p>Stage Two (C)</p> Signup and view all the answers

In what stage of Anabolism are activated precursors assembled into complex molecules?

<p>Stage Three (D)</p> Signup and view all the answers

What equation represents the relationship between catabolism, anabolism, and metabolism?

<p>Catabolism + Anabolism = Metabolism (B)</p> Signup and view all the answers

Which stage of the Anabolism process involves the activation of precursors into reactive forms?

<p>Stage Two (C)</p> Signup and view all the answers

What does a body mass index (BMI) over 25 signify?

<p>Being overweight (C)</p> Signup and view all the answers

What is described by the term Metabolically Healthy Obesity (MHO)?

<p>Obese individuals with no metabolic complications (A)</p> Signup and view all the answers

What is a possible factor contributing to Metabolically Healthy Obesity (MHO)?

<p>Genetics and inflammatory factors (C)</p> Signup and view all the answers

What is positively associated with Metabolically Healthy Obesity (MHO)?

<p>Absence of metabolic syndrome (D)</p> Signup and view all the answers

Which factor is NOT mentioned as potentially contributing to Metabolically Healthy Obesity (MHO)?

<p>Visceral fat accumulation (D)</p> Signup and view all the answers

How is Metabolically Healthy Obesity (MHO) defined according to the text?

<p>Obesity without metabolic-associated complications (C)</p> Signup and view all the answers

What is the primary emphasis of the text regarding health and body size?

<p>Hold space for individual experiences within health factors (B)</p> Signup and view all the answers

How is obesity defined in the adult world according to the text?

<p>Defined by a body mass index (BMI) over 30 (C)</p> Signup and view all the answers

Which of the following vitamins require a transport protein for absorption?

<p>Vitamin B12 (C)</p> Signup and view all the answers

During the absorptive state, what happens to glucose?

<p>It is stored as glycogen (B)</p> Signup and view all the answers

Which hormone is dominant in the postabsorptive state?

<p>Glucagon (D)</p> Signup and view all the answers

What is the primary function of the liver in the absorptive state?

<p>Converting glucose to triglycerides (A)</p> Signup and view all the answers

What is the result of insulin resistance?

<p>Increased insulin production (C)</p> Signup and view all the answers

What is the effect of epinephrine on glycogen breakdown?

<p>It increases glycogen breakdown (B)</p> Signup and view all the answers

What is the result of chronically elevated stress hormones on glucose levels?

<p>Increased glucose levels (B)</p> Signup and view all the answers

Which of the following is NOT a target tissue for insulin?

<p>Kidney (D)</p> Signup and view all the answers

Which macronutrient provides twice the amount of energy compared to carbohydrates?

<p>Lipids (B)</p> Signup and view all the answers

What is the primary source of nitrogen for the body?

<p>Proteins (B)</p> Signup and view all the answers

Which of the following macronutrients is stored in the liver and muscles for quick energy availability?

<p>Complex carbohydrates (A)</p> Signup and view all the answers

What are substances formed from linoleic (ω-6) and linolenic (ω-3) acids that are involved in cellular signaling and DNA regulation?

<p>Lipoxins and Resolvins (C)</p> Signup and view all the answers

Which amino acids are considered essential and cannot be synthesized by the body?

<p>Histidine, isoleucine, leucine (B)</p> Signup and view all the answers

Nutrients (except fats) absorbed by the small intestine capillaries are delivered to the liver via which system?

<p>Hepatic Portal System (B)</p> Signup and view all the answers

Which structures in the small intestine greatly enhance the absorption of nutrients due to their large surface area?

<p>Microvilli (D)</p> Signup and view all the answers

What is responsible for creating a hyponatremic intracellular environment in intestinal villus cells?

<p>Na+/K+ Pumps (D)</p> Signup and view all the answers

Which process relies on the movement of sodium through a sodium channel for transporting monosaccharides?

<p>Absorption of carbohydrates (B)</p> Signup and view all the answers

What enzyme is responsible for breaking down proteins in the small intestine?

<p>Trypsin (C)</p> Signup and view all the answers

How are monoglycerides and free fatty acids absorbed into the cells of the small intestine?

<p>Diffusion (D)</p> Signup and view all the answers

Which enzyme is responsible for the hydrolysis of macromolecules in digestion?

<p>Peptidase (A)</p> Signup and view all the answers

What happens to lipids after they are absorbed into the cells of the small intestine?

<p>They are reformed into triglycerides within the cell (A)</p> Signup and view all the answers

Which enzyme is crucial in breaking down lipids in the small intestine?

<p>Lipase (A)</p> Signup and view all the answers

What is the function of the pancreatic enzyme saccharidase?

<p>Digest carbohydrates and polysaccharides (A)</p> Signup and view all the answers

How are monosaccharides and amino acids absorbed by intestinal cells?

<p>Active transport (D)</p> Signup and view all the answers

What is the percentage of Hb A2 in adult hemoglobin?

<p>1.5-3.5% (A)</p> Signup and view all the answers

What is the function of phagocytic macrophages in the liver, spleen, bone marrow, and lymph nodes?

<p>To break down RBCs (C)</p> Signup and view all the answers

What is the PO2 at which hemoglobin is approximately 78% saturated with oxygen?

<p>40 (C)</p> Signup and view all the answers

What is the effect of increased metabolic demand on hemoglobin's oxygen affinity?

<p>It decreases hemoglobin's oxygen affinity (C)</p> Signup and view all the answers

What is the lifespan of platelets in circulation?

<p>9 days (C)</p> Signup and view all the answers

What is the function of granules in granulocytes?

<p>To kill microorganisms and catabolize debris (A)</p> Signup and view all the answers

What is the percentage of neutrophils among total white blood cells?

<p>60-70% (A)</p> Signup and view all the answers

What is the lifespan of mature neutrophils?

<p>4-5 days (A)</p> Signup and view all the answers

What is the function of thrombopoietin (TPO)?

<p>To stimulate platelet synthesis (C)</p> Signup and view all the answers

What is the primary function of leukocytes?

<p>To defend against microorganisms and remove debris (B)</p> Signup and view all the answers

What is the role of albumin in the blood?

<p>Maintenance of colloidal osmotic pressure (A)</p> Signup and view all the answers

Which of the following is NOT a function of blood as mentioned in the text?

<p>Synthesis of glucose (C)</p> Signup and view all the answers

Which type of cells produce immunoglobulins in the blood?

<p>Plasma cells (C)</p> Signup and view all the answers

Which of the following is NOT a function of plasma proteins?

<p>Synthesis of red blood cells (C)</p> Signup and view all the answers

What is the primary function of fibrinogen in the blood?

<p>Clotting (A)</p> Signup and view all the answers

In the blood, which protein plays a vital role in regulating the passage of water and solutes through capillaries?

<p>Albumin (B)</p> Signup and view all the answers

Which of the following components creates oncotic pressure in the vasculature?

<p>Plasma proteins (C)</p> Signup and view all the answers

What is the function of clotting factors in the blood?

<p>Clot formation (D)</p> Signup and view all the answers

Which component of blood is responsible for binding and carrying molecules like iron, copper, and vitamins?

<p>Plasma proteins (C)</p> Signup and view all the answers

What is the primary source of most plasma proteins in the blood?

<p>Liver (A)</p> Signup and view all the answers

What hormone or growth factor increases red blood cell (RBC) production?

<p>Erythropoietin (A)</p> Signup and view all the answers

What is the primary site of hematopoietic stem cells in adults?

<p>Bone Marrow (A)</p> Signup and view all the answers

Which component of blood undergoes differentiation to produce granulocytes and monocytes?

<p>Myeloid precursors (D)</p> Signup and view all the answers

What is the lifespan of mature red blood cells (RBCs)?

<p>120 days (A)</p> Signup and view all the answers

Which vitamin is an important cofactor for the development of red blood cells?

<p>Vitamin B12 (D)</p> Signup and view all the answers

What protein in red blood cells is responsible for transporting carbon dioxide (CO2)?

<p>Hemoglobin (A)</p> Signup and view all the answers

Which organ releases Erythropoietin (EPO) when it senses low oxygen levels?

<p>Kidneys (D)</p> Signup and view all the answers

Where do lymphopoietic stem cells become Pro NK and Pro T cells before migrating to differentiate into NK cells and T cells?

<p>Thymus (A)</p> Signup and view all the answers

Which type of bone marrow is characterized by being inactive with a large amount of fat?

<p>Yellow Marrow (C)</p> Signup and view all the answers

What is the function of a tetramer in hemoglobin with respect to oxygen?

<p>Reversibly bind one oxygen molecule (D)</p> Signup and view all the answers

What type of cells contains granules that have toxic chemicals to destroy parasites and viruses?

<p>Eosinophils (D)</p> Signup and view all the answers

Which cells differentiate in the thymus and are critical for cell-mediated immunity?

<p>T-Lymphocytes (C)</p> Signup and view all the answers

Which type of cells are involved in allergic reactions and parasitic infections?

<p>T-Lymphocytes (C)</p> Signup and view all the answers

Which white blood cells can transform into macrophages and travel to sites of inflammation?

<p>Monocytes (A)</p> Signup and view all the answers

What deficiency puts the body at high risk for atypical infections, especially from fungi?

<p>Neutropenia (C)</p> Signup and view all the answers

Which leukocytes originate from lymphoid stem cells and have a kidney-shaped nucleus?

<p>Monocytes (A)</p> Signup and view all the answers

Which cells contain granules that stain blue with basic dye and contain histamine?

<p>Basophils (B)</p> Signup and view all the answers

What is the most common agranulocyte and makes up 30% of total leukocytes?

<p>Lymphocytes (C)</p> Signup and view all the answers

Which leukocytes are characterized by high numbers during Type 1 hypersensitivity reactions and asthma?

<p>Eosinophils (B)</p> Signup and view all the answers

Which cells are similar to mast cells and are involved in allergic and hypersensitivity reactions?

<p>Basophils (D)</p> Signup and view all the answers

What is the primary function of von Willebrand factor in hemostasis?

<p>To act as a carrier protein for Factor VIII (A)</p> Signup and view all the answers

What is the consequence of platelet activation during hemostasis?

<p>Formation of a platelet plug (A)</p> Signup and view all the answers

What is the role of endothelium in normal conditions?

<p>To suppress spontaneous activation of platelets and the clotting system (D)</p> Signup and view all the answers

What is the final step in the process of hemostasis?

<p>Fibrinolysis and the beginning of the healing process (D)</p> Signup and view all the answers

What is the consequence of endothelial damage during hemostasis?

<p>Vasoconstriction and exposure of subendothelial matrix (A)</p> Signup and view all the answers

What is the role of glycoprotein Ib (GPIb) in hemostasis?

<p>To bind to von Willebrand factor (B)</p> Signup and view all the answers

What is the function of tissue factor in hemostasis?

<p>To activate the clotting system (C)</p> Signup and view all the answers

What is the consequence of platelet adhesion during hemostasis?

<p>Formation of a platelet plug (C)</p> Signup and view all the answers

What is the role of fibrin in hemostasis?

<p>To form a clot that reinforces the platelet plug (A)</p> Signup and view all the answers

What is the function of thromboxane A2 during hemostasis?

<p>To cause vasoconstriction (D)</p> Signup and view all the answers

What initiates the production of thromboxane A2 by platelets?

<p>Degranulation of platelets (C)</p> Signup and view all the answers

Which factor in the Common Pathway of the Clotting Cascade converts prothrombin into thrombin?

<p>Factor X (B)</p> Signup and view all the answers

What is the primary function of Antithrombin III in hemostasis?

<p>Inhibiting thrombin (B)</p> Signup and view all the answers

Which enzyme activates plasminogen into plasmin in the lysis of blood clots?

<p>Tissue plasminogen activator (t-PA) (B)</p> Signup and view all the answers

Which deficiency does NOT result in prolonged bleeding according to the text?

<p>Factor XII deficiency (B)</p> Signup and view all the answers

What activates Protein C and S in the presence of the thrombomodulin/thrombin complex?

<p>Thrombin (C)</p> Signup and view all the answers

What is the primary role of Warfarin (coumadin) in hemostasis?

<p>Decreasing thrombin production (B)</p> Signup and view all the answers

Which of the following is a common function of Protein C and S in hemostasis?

<p>Inactivating clotting factors Va and VIIIa (B)</p> Signup and view all the answers

In the intrinsic pathway of the Clotting Cascade, what leads to the activation of Factor XII?

<p>Contact with subendothelial collagen (B)</p> Signup and view all the answers

Which isoform converts arachidonic acid to thromboxane A2 in platelets?

<p>COX-1 (D)</p> Signup and view all the answers

What is the primary cause of microcytic-hypochromic anemia?

<p>Iron deficiency (D)</p> Signup and view all the answers

Which type of anemia is caused by a problem with RBC maturation from precursor cells?

<p>Macrocytic anemia (B)</p> Signup and view all the answers

What is the effect of acute blood loss on EPO production?

<p>Increased EPO production (A)</p> Signup and view all the answers

What is the consequence of chronic blood loss if it exceeds the replacement capacity of the bone marrow?

<p>Anemia only occurs (C)</p> Signup and view all the answers

What is the result of decreased RBC production in the bone marrow?

<p>Aplastic anemia (D)</p> Signup and view all the answers

What is the primary mechanism of anemia due to increased RBC destruction?

<p>Increased RBC destruction (D)</p> Signup and view all the answers

What is the consequence of ineffective erythropoiesis?

<p>Macrocytic anemia (A)</p> Signup and view all the answers

What is the primary cause of normocytic-normochromic anemia?

<p>Blood loss (D)</p> Signup and view all the answers

What is the effect of chronic blood loss on iron levels?

<p>Decreased iron levels (D)</p> Signup and view all the answers

What is the primary mechanism of anemia due to blood loss?

<p>Loss of red cells out of the body (C)</p> Signup and view all the answers

What is the main difference between Hemoglobin A and Hemoglobin A2?

<p>Hemoglobin A has two alpha and two beta chains, whereas Hemoglobin A2 has two alpha and two delta chains (D)</p> Signup and view all the answers

What is the primary cause of Anemia of Chronic Disease?

<p>Decreased erythropoiesis and impaired iron utilization in people with chronic systemic disease or inflammation (C)</p> Signup and view all the answers

What is the result of having four beta chains joined together in a hemoglobin molecule?

<p>Hemoglobin H, which is a pathologic hemoglobin variant (B)</p> Signup and view all the answers

What is the primary cause of Polycythemia Vera?

<p>Genetic mutation that leads to the proliferation of erythroid precursor cells in the bone marrow (A)</p> Signup and view all the answers

What is the function of cytochrome b5 reductase in the Embden-Meyerhof Pathway?

<p>To convert Fe+3 to Fe+2 in hemoglobin molecules (B)</p> Signup and view all the answers

What is the result of having four gamma chains joined together in a hemoglobin molecule?

<p>Hemoglobin Barts, which is a fetal hemoglobin variant (A)</p> Signup and view all the answers

What is the primary cause of Iron Deficiency Anemia?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary feature of Thalassemia?

<p>An absence of alpha globin chains in hemoglobin molecules (A)</p> Signup and view all the answers

What is the result of having Hemoglobin with Fe+3 instead of Fe+2?

<p>The hemoglobin molecule cannot bind to oxygen at all (D)</p> Signup and view all the answers

What is the primary cause of Methemoglobinemia?

<p>A genetic mutation that stabilizes iron in the Fe+3 form (B)</p> Signup and view all the answers

What is the primary source of fuel for red blood cells?

<p>Glycolysis (B)</p> Signup and view all the answers

Which pathway converts glucose to pyruvate in red blood cells?

<p>Hexose Monophosphate Shunt (B)</p> Signup and view all the answers

What is the genetic basis of G6PD Deficiency?

<p>X-Linked Recessive (D)</p> Signup and view all the answers

Which stimulus can trigger significant damage to red blood cells in those with G6PD Deficiency?

<p>Infections (A)</p> Signup and view all the answers

Why does the Hexose Monophosphate Shunt take place in red blood cells?

<p>To generate NADH (B)</p> Signup and view all the answers

Which of the following is a characteristic symptom of G6PD Deficiency?

<p>Jaundice (B)</p> Signup and view all the answers

What is the most common trigger of significant symptoms in those with G6PD Deficiency?

<p>Viral Infections (C)</p> Signup and view all the answers

Which of the following symptoms is NOT associated with Methemoglobinemia?

<p>Hyperthermia (A)</p> Signup and view all the answers

What is the main purpose of the Hexose Monophosphate Shunt in red blood cells?

<p>Generate NADH (D)</p> Signup and view all the answers

What is the primary consequence of lack of NADH in red blood cells with G6PD Deficiency under oxidative stress?

<p>Hemolysis (B)</p> Signup and view all the answers

What is the primary function of bile salts in the digestive process?

<p>Creating emulsification of fats for absorption (D)</p> Signup and view all the answers

What triggers the release of bile salts from the gallbladder into the duodenum?

<p>Entry of fatty acids and amino acids into the duodenum (A)</p> Signup and view all the answers

What is the purpose of creating micelles in the digestive process?

<p>Facilitate the absorption of fats by increasing surface area (D)</p> Signup and view all the answers

Where do triglycerides get reassembled into their original form after absorption into the small intestine cells?

<p>Ileum (C)</p> Signup and view all the answers

What is the fate of triglycerides once they are exocytosed from the cells into the lymphatic channel?

<p>Directly enter the thoracic duct near the heart (C)</p> Signup and view all the answers

What is the main function of bile salts in the digestion and absorption of fats?

<p>Aiding in the emulsification of fats for absorption (A)</p> Signup and view all the answers

What is the viral structure of hepatitis A virus (HAV)?

<p>Linear, single-stranded RNA in a protein coat (B)</p> Signup and view all the answers

Which antibody is diagnostic evidence of recent hepatitis A virus (HAV) infection?

<p>IgM (B)</p> Signup and view all the answers

In which phase of the disease does hepatitis A virus (HAV) typically cause liver cell damage?

<p>Icteric phase (D)</p> Signup and view all the answers

What is the primary mode of transmission of Hepatitis B Virus (HBV) among sexual workers?

<p>Sexual (B)</p> Signup and view all the answers

Which body fluid has the highest concentration of Hepatitis B Virus (HBV)?

<p>Blood (A)</p> Signup and view all the answers

What is a key characteristic of Hepatitis B Virus (HBV) that hinders the host immune system's response?

<p>Release of immunogenic decoy particles (A)</p> Signup and view all the answers

What is the primary function of the hepatic portal system in the liver?

<p>Mixing nutrient-rich and oxygen-poor blood from the gut (A)</p> Signup and view all the answers

What is the main role of sinusoids in the liver lobules?

<p>Functioning as the capillaries of the liver (A)</p> Signup and view all the answers

In which zone of the liver lobules do hepatocytes specialize in glycolysis and lipogenesis?

<p>Zone III (B)</p> Signup and view all the answers

What best describes the role of a bile canaliculus in the liver?

<p>Diluted intercellular spaces between hepatocytes (A)</p> Signup and view all the answers

What is the main purpose of liver sinusoids in relation to blood flow?

<p>Allowing significant flow of larger molecules (C)</p> Signup and view all the answers

What distinguishes a bile canaliculus from a duct in the liver?

<p>Intercellular space vs. hollow tubular structure (B)</p> Signup and view all the answers

What is the primary role of conjugated bilirubin in the body?

<p>Turns feces brown upon excretion (D)</p> Signup and view all the answers

Why does the liver convert unsoluble bilirubin into conjugated bilirubin?

<p>To make it water-soluble for excretion (B)</p> Signup and view all the answers

What happens to unconjugated bilirubin after binding to albumin in the bloodstream?

<p>Travels to the liver for conjugation (D)</p> Signup and view all the answers

How is biliverdin produced in the breakdown of hemoglobin?

<p>By separation of globin from heme (A)</p> Signup and view all the answers

When is bilirubin considered a bad thing in the body?

<p>When it is constantly being created in large amounts (B)</p> Signup and view all the answers

Why is the passive process of reabsorption of bile salts in the colon important?

<p>To facilitate the recycling of bile salts (A)</p> Signup and view all the answers

What is one of the major functions of the liver described in the text?

<p>Creation and secretion of bile (C)</p> Signup and view all the answers

Where do the absorbed nutrients go first upon arriving in the body?

<p>Liver (A)</p> Signup and view all the answers

Which vessel carries absorbed nutrients to the liver for processing?

<p>Hepatic portal vein (A)</p> Signup and view all the answers

Apart from filtering, what is another function of the liver mentioned in the text?

<p>Synthesis of plasma proteins (D)</p> Signup and view all the answers

Where does the blood go after traveling through the Hepatic Veins?

<p>Superior vena cava (B)</p> Signup and view all the answers

What does the liver serve as before nutrients enter the general circulation?

<p>A processing site for absorbed nutrients (B)</p> Signup and view all the answers

What is the primary function of HBeAg in Hepatitis B infection?

<p>Reflects active replication of the virus (A)</p> Signup and view all the answers

What is the significance of anti-HBs Ab’s in Hepatitis B infection?

<p>Documents recovery and/or immunity to HBV infection (A)</p> Signup and view all the answers

Which sexually transmitted infection is most commonly transmitted through sharing injection equipment and in healthcare settings?

<p>Hepatitis C (B)</p> Signup and view all the answers

What is the risk of developing cirrhosis of the liver within 20 years for people with chronic HCV infection?

<p>15–30% (A)</p> Signup and view all the answers

Which is the primary cause of Cirrhosis?

<p>Chronic alcohol abuse (D)</p> Signup and view all the answers

What is the primary diagnostic test for assessing the degree of liver damage in patients with chronic Hepatitis C infection?

<p>Liver biopsy (D)</p> Signup and view all the answers

How is chronic Hepatitis C diagnosed after testing positive for anti-HCV antibodies?

<p>Nucleic acid test for HCV RNA (A)</p> Signup and view all the answers

What does cirrhosis of the liver result from?

<p>Chronic inflammation (C)</p> Signup and view all the answers

What causes capillary hydrostatic pressure to exceed capillary osmotic pressure in the context of Cirrhosis?

<p>Reduced serum albumin levels (B)</p> Signup and view all the answers

What is the primary function of anti-HBe in Hepatitis B infection?

<p>Confirms immunity to HBV (D)</p> Signup and view all the answers

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