Enzyme kinetics
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Questions and Answers

Which of the following measures the speed of P formation once ES has been made?

  • Enzyme Inhibition
  • Kcat (correct)
  • Enzyme Efficiency
  • Km

    • What does Kcat/Km measure?

  • Enzyme efficiency (correct)
  • Enzyme inhibition
  • Binding affinity of E and S
  • Speed of P formation

    • What are some applications of enzyme inhibition?

  • Physiological feedback mechanisms
  • Enzyme kinetics
  • Clinical therapies (correct)
  • Enzyme efficiency

    • What type of inhibition is reversible and involves competitive binding of the inhibitor to the active site of the enzyme?

    <p>Reversible inhibition</p> Signup and view all the answers

    What is an example of a competitive inhibitor?

    <p>Methotrexate</p> Signup and view all the answers

    In competitive inhibition, does Vmax change?

    <p>No</p> Signup and view all the answers

    In uncompetitive inhibition, is Vmax lower or higher?

    <p>Lower</p> Signup and view all the answers

    What happens in irreversible enzyme inhibition?

    <p>An inhibitor forms a covalent bond with the active site of the enzyme</p> Signup and view all the answers

    What happens when an activator binds to a multi-subunit allosteric enzyme?

    <p>Enhances binding of the substrate to other subunits</p> Signup and view all the answers

    Which enzyme has a lower Vmax and lower Km compared to glucokinase?

    <p>Hexokinase</p> Signup and view all the answers

    What turns off hexokinase?

    <p>High concentrations of glucose-6-P</p> Signup and view all the answers

    Where is glucokinase predominantly found?

    <p>Liver</p> Signup and view all the answers

    Why can't other tissues convert excess glucose to glycogen?

    <p>They lack glucokinase</p> Signup and view all the answers

    What is the significance of adding a phosphate group to glucose?

    <p>It traps glucose inside the cell</p> Signup and view all the answers

    Which pathway is used for energy when glucose levels are low?

    <p>Glycolysis</p> Signup and view all the answers

    What does high Vmax indicate?

    <p>High capacity to convert substrate to product</p> Signup and view all the answers

    What is the role of aldehyde dehydrogenase?

    <p>Converts acetaldehyde to acetate</p> Signup and view all the answers

    Why is hexokinase inhibited by glucose-6-P, but glucokinase is not?

    <p>Different regulatory mechanisms</p> Signup and view all the answers

    What does a lower Km indicate?

    <p>Higher affinity for substrate</p> Signup and view all the answers

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