Enzyme kinetics

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Questions and Answers

Which of the following measures the speed of P formation once ES has been made?

  • Enzyme Inhibition
  • Kcat (correct)
  • Enzyme Efficiency
  • Km

What does Kcat/Km measure?

  • Enzyme efficiency (correct)
  • Enzyme inhibition
  • Binding affinity of E and S
  • Speed of P formation

What are some applications of enzyme inhibition?

  • Physiological feedback mechanisms
  • Enzyme kinetics
  • Clinical therapies (correct)
  • Enzyme efficiency

What type of inhibition is reversible and involves competitive binding of the inhibitor to the active site of the enzyme?

<p>Reversible inhibition (D)</p> Signup and view all the answers

What is an example of a competitive inhibitor?

<p>Methotrexate (A)</p> Signup and view all the answers

In competitive inhibition, does Vmax change?

<p>No (A)</p> Signup and view all the answers

In uncompetitive inhibition, is Vmax lower or higher?

<p>Lower (C)</p> Signup and view all the answers

What happens in irreversible enzyme inhibition?

<p>An inhibitor forms a covalent bond with the active site of the enzyme (D)</p> Signup and view all the answers

What happens when an activator binds to a multi-subunit allosteric enzyme?

<p>Enhances binding of the substrate to other subunits (B)</p> Signup and view all the answers

Which enzyme has a lower Vmax and lower Km compared to glucokinase?

<p>Hexokinase (B)</p> Signup and view all the answers

What turns off hexokinase?

<p>High concentrations of glucose-6-P (C)</p> Signup and view all the answers

Where is glucokinase predominantly found?

<p>Liver (A)</p> Signup and view all the answers

Why can't other tissues convert excess glucose to glycogen?

<p>They lack glucokinase (C)</p> Signup and view all the answers

What is the significance of adding a phosphate group to glucose?

<p>It traps glucose inside the cell (B)</p> Signup and view all the answers

Which pathway is used for energy when glucose levels are low?

<p>Glycolysis (B)</p> Signup and view all the answers

What does high Vmax indicate?

<p>High capacity to convert substrate to product (B)</p> Signup and view all the answers

What is the role of aldehyde dehydrogenase?

<p>Converts acetaldehyde to acetate (A)</p> Signup and view all the answers

Why is hexokinase inhibited by glucose-6-P, but glucokinase is not?

<p>Different regulatory mechanisms (A)</p> Signup and view all the answers

What does a lower Km indicate?

<p>Higher affinity for substrate (C)</p> Signup and view all the answers

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