Metabolism in Medical Physiology - Dr. Derick van Vuuren
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Questions and Answers

What is the role of the slowest enzyme in a metabolic pathway?

  • It determines the overall rate of the pathway (correct)
  • It has no significant effect on the pathway rate
  • It catalyzes the first reaction in the pathway
  • It catalyzes the final reaction in the pathway

How can enzyme activity be modulated through gene expression?

  • Non-competitive inhibition
  • Repression and induction (correct)
  • Allosteric regulation
  • Competitive inhibition

What is the effect of an allosteric effector on an enzyme?

  • It non-competitively inhibits the enzyme
  • It competitively inhibits the enzyme
  • It causes a conformational change in the enzyme (correct)
  • It irreversibly inhibits the enzyme

What is the mechanism of non-competitive enzyme inhibition?

<p>The inhibitor binds to an allosteric site on the enzyme (A)</p> Signup and view all the answers

Which type of enzyme inhibition is reversible?

<p>Both competitive and non-competitive inhibition (A)</p> Signup and view all the answers

What is the effect of protein phosphorylation on enzyme activity?

<p>It can either increase or decrease enzyme activity (D)</p> Signup and view all the answers

Which type of enzyme inhibition is irreversible?

<p>Irreversible inhibition (B)</p> Signup and view all the answers

What is the relationship between the substrate and a competitive inhibitor?

<p>They bind to the same site on the enzyme (B)</p> Signup and view all the answers

Which enzyme in a metabolic pathway is the most crucial for regulation?

<p>The rate-limiting enzyme (D)</p> Signup and view all the answers

Which of the following is a mechanism by which enzyme activity can be modulated?

<p>Protein phosphorylation (A)</p> Signup and view all the answers

What is the effect of a non-competitive inhibitor on an enzyme?

<p>It binds to a site other than the active site, changing the enzyme's conformation. (A)</p> Signup and view all the answers

How does the presence of an allosteric effector affect an enzyme's activity?

<p>It changes the enzyme's conformation, either increasing or decreasing its activity. (D)</p> Signup and view all the answers

Which of the following is a mechanism by which gene expression can modulate enzyme activity?

<p>Repression or induction of enzyme synthesis (C)</p> Signup and view all the answers

What is the relationship between a competitive inhibitor and the substrate of an enzyme?

<p>The competitive inhibitor and the substrate bind to the same active site on the enzyme. (C)</p> Signup and view all the answers

Which enzyme in a metabolic pathway is the most crucial for regulation?

<p>The enzyme that catalyzes the first irreversible step in the pathway (B)</p> Signup and view all the answers

What is the effect of protein phosphorylation on enzyme activity?

<p>It can either increase or decrease the enzyme's activity, depending on the specific site of phosphorylation. (C)</p> Signup and view all the answers

What is the effect of an irreversible enzyme inhibitor?

<p>It binds to the enzyme and forms a stable complex, permanently inactivating the enzyme. (A)</p> Signup and view all the answers

Which type of enzyme inhibition is reversible?

<p>Both competitive and non-competitive inhibition (D)</p> Signup and view all the answers

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