Metabolism in Medical Physiology - Dr. Derick van Vuuren
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Questions and Answers

What is the role of the slowest enzyme in a metabolic pathway?

  • It determines the overall rate of the pathway (correct)
  • It has no significant effect on the pathway rate
  • It catalyzes the first reaction in the pathway
  • It catalyzes the final reaction in the pathway

    • How can enzyme activity be modulated through gene expression?

  • Non-competitive inhibition
  • Repression and induction (correct)
  • Allosteric regulation
  • Competitive inhibition

    • What is the effect of an allosteric effector on an enzyme?

  • It non-competitively inhibits the enzyme
  • It competitively inhibits the enzyme
  • It causes a conformational change in the enzyme (correct)
  • It irreversibly inhibits the enzyme

    • What is the mechanism of non-competitive enzyme inhibition?

    <p>The inhibitor binds to an allosteric site on the enzyme</p> Signup and view all the answers

    Which type of enzyme inhibition is reversible?

    <p>Both competitive and non-competitive inhibition</p> Signup and view all the answers

    What is the effect of protein phosphorylation on enzyme activity?

    <p>It can either increase or decrease enzyme activity</p> Signup and view all the answers

    Which type of enzyme inhibition is irreversible?

    <p>Irreversible inhibition</p> Signup and view all the answers

    What is the relationship between the substrate and a competitive inhibitor?

    <p>They bind to the same site on the enzyme</p> Signup and view all the answers

    Which enzyme in a metabolic pathway is the most crucial for regulation?

    <p>The rate-limiting enzyme</p> Signup and view all the answers

    Which of the following is a mechanism by which enzyme activity can be modulated?

    <p>Protein phosphorylation</p> Signup and view all the answers

    What is the effect of a non-competitive inhibitor on an enzyme?

    <p>It binds to a site other than the active site, changing the enzyme's conformation.</p> Signup and view all the answers

    How does the presence of an allosteric effector affect an enzyme's activity?

    <p>It changes the enzyme's conformation, either increasing or decreasing its activity.</p> Signup and view all the answers

    Which of the following is a mechanism by which gene expression can modulate enzyme activity?

    <p>Repression or induction of enzyme synthesis</p> Signup and view all the answers

    What is the relationship between a competitive inhibitor and the substrate of an enzyme?

    <p>The competitive inhibitor and the substrate bind to the same active site on the enzyme.</p> Signup and view all the answers

    Which enzyme in a metabolic pathway is the most crucial for regulation?

    <p>The enzyme that catalyzes the first irreversible step in the pathway</p> Signup and view all the answers

    What is the effect of protein phosphorylation on enzyme activity?

    <p>It can either increase or decrease the enzyme's activity, depending on the specific site of phosphorylation.</p> Signup and view all the answers

    What is the effect of an irreversible enzyme inhibitor?

    <p>It binds to the enzyme and forms a stable complex, permanently inactivating the enzyme.</p> Signup and view all the answers

    Which type of enzyme inhibition is reversible?

    <p>Both competitive and non-competitive inhibition</p> Signup and view all the answers

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