Metabolism and Energy Pathways
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Questions and Answers

In the context of weight loss, what physiological basis is mentioned in the reading material as a cause for weight regain?

  • Metabolic adaptations (correct)
  • Reduced appetite
  • Increased resting heart rate
  • Improved insulin sensitivity

During prolonged fasting, what is the primary source of energy for the brain?

  • Fatty acids
  • Gluconeogenesis from glycerol
  • Ketone bodies (correct)
  • Glucose from glycogen

In prolonged fasting, what is the primary origin of blood glucose?

  • Exogenous
  • Glycogen; Hepatic gluconeogenesis (correct)
  • Glucose, ketone bodies
  • Glucose

In the context of fuel utilization during early fasting, which statement is true?

<p>Relies mainly on glucose from glycogen stores (A)</p> Signup and view all the answers

What physiological changes occur in severe weight loss with respect to cardiovascular and renal functions?

<p>Development of tachycardia as a compensatory mechanism (A)</p> Signup and view all the answers

What is the primary goal of adapting to fasting?

<p>Meet energy needs (D)</p> Signup and view all the answers

Why does the brain require a consistent supply of glucose?

<p>To prevent coma and death (A)</p> Signup and view all the answers

What is the energy paradox in relation to the brain's energy needs?

<p>The brain requires glucose but almost all energy is stored as fatty acids (C)</p> Signup and view all the answers

Which macronutrient is the most likely to favor energy storage and weight gain according to the carbohydrate-insulin model of obesity?

<p>Carbohydrates (C)</p> Signup and view all the answers

Why does burning glycogen and protein result in a greater weight loss that is mostly due to water loss?

<p>Glycogen binds more water during metabolism (A)</p> Signup and view all the answers

What is the primary purpose of liver glycogen?

<p>Immediate release of glucose into the blood (A)</p> Signup and view all the answers

What is the main reason for sparing protein during fasting?

<p>To maintain muscle mass (C)</p> Signup and view all the answers

How do high carbohydrate and high fat intake together cause fat storage?

<p>By causing excess energy intake (D)</p> Signup and view all the answers

What is the role of insulin in response to a meal?

<p>To promote glucose uptake by tissues (B)</p> Signup and view all the answers

What happens to blood glucose levels in early diabetes or insulin resistance?

<p>Blood glucose levels increase significantly (A)</p> Signup and view all the answers

How does the body adapt to fasting in terms of protein usage?

<p>The body spares protein to maintain lean tissue mass (B)</p> Signup and view all the answers

What is the consequence of decreased insulin sensitivity in the context of the carbohydrate-insulin model of obesity?

<p>Increased fat storage and weight gain (B)</p> Signup and view all the answers

According to the meta-analysis, what is the main driver of weight gain?

<p>Excess energy (B)</p> Signup and view all the answers

What is the impact of a higher protein diet during energy-reduced low-fat diets?

<p>Offsets REE by about 150 kcal/d (A)</p> Signup and view all the answers

What is the body's main adaptation to fasting, according to the study?

<p>Switching main fuels from glucose to fatty acids and keto acids (C)</p> Signup and view all the answers

In weight-reducing diets, what effect does macronutrient composition (fat to carbohydrate ratio) have on total weight loss?

<p>Has no effect on total weight loss (A)</p> Signup and view all the answers

What signals does energy restriction and weight loss induce, according to the study?

<p>Increase appetite and food intake, decrease metabolism (B)</p> Signup and view all the answers

What did the study find about the effect of high-protein diets on weight maintenance after weight loss?

<p>Aids in weight maintenance after weight loss (A)</p> Signup and view all the answers

What is the body's main response to increase in appetite and food intake during energy restriction and weight loss?

<p>Decrease in metabolism (B)</p> Signup and view all the answers

What are the metabolic complications associated with nutritional repletion, as discussed in the text?

<p>Rapid shift of electrolytes and intracellular anions and cations to extracellular space (B)</p> Signup and view all the answers

During refeeding, what is a physiological change that may lead to edema?

<p>Increased glycogen synthesis (C)</p> Signup and view all the answers

What is the aim of providing 100-150g of glucose during refeeding?

<p>To avoid refeeding syndrome (C)</p> Signup and view all the answers

In response to diet-induced weight loss, what physiological change leads to a decrease in energy expenditure?

<p>Reduction in physical activity (D)</p> Signup and view all the answers

What is the primary cause of decreased energy expenditure after weight loss, as mentioned in the text?

<p>Reduced sympathetic drive (D)</p> Signup and view all the answers

What is the effect of increasing exercise on energy expenditure, according to the text?

<p>Initial increments in energy expenditure can be greater than expected (B)</p> Signup and view all the answers

What may be the result of consuming a diet high in carbohydrates according to the carbohydrate-insulin model?

<p>Increased insulin secretion and fat storage (C)</p> Signup and view all the answers

What is the basis for the 'metabolic advantage' associated with low-carb diets as mentioned in the text?

<p>'Increased lipolysis and use of free fatty acids' (B)</p> Signup and view all the answers

What did the 6-year follow-up study reveal about the magnitude of metabolic adaptation and its relation to weight regain?

<p>The magnitude of metabolic adaptation increased after 6 years but was not related to weight regain (C)</p> Signup and view all the answers

What is a likely consequence of consuming an isocaloric diet high in carbohydrates based on energy partitioning?

<p>Preferential energy storage as body fat over body protein (C)</p> Signup and view all the answers

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