10 Questions
What happens to the activity of glycogen phosphorylase kinase, glycogen phosphorylase, and hormone-sensitive lipase of adipose tissue in their dephosphorylated form?
They are inactivated
What is the role of insulin in enzyme synthesis in the fed state?
Increase the synthesis of key enzymes
How do changes in enzyme synthesis affect enzyme molecules according to the text?
Increase or decrease the number of enzyme molecules
Why does the liver become a net consumer of glucose after a meal containing carbohydrates?
Increased activity of insulin-independent glucose transporter
Which mechanism primarily involves the regulation of enzyme synthesis through transcription?
Induction-repression of enzyme synthesis
What allows the liver to process and distribute dietary nutrients effectively?
Passage of absorbed nutrients through the hepatic portal vein
Which enzyme is allosterically inhibited by fructose 2,6-bisphosphate?
Fructose 1,6-bisphosphatase
In the well-fed state, regulatory mechanisms ensure that available nutrients are captured as which of the following?
Glycogen, TAG, and protein
Which enzymes are mostly in the dephosphorylated form and active during the absorptive state?
Covalently regulated enzymes
Which type of modification involves the addition or removal of phosphate groups from specific residues of proteins?
Covalent modification
Learn about the four mechanisms that control the flow of intermediates through metabolic pathways: substrate availability, allosteric regulation, covalent modification of enzymes, and induction-repression of enzyme synthesis. Understand how each mechanism operates on different timescales and helps the body adapt to various physiological situations.
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