Meta-Analysis Random Effect Model

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What is the most appropriate model to use in a meta-analysis with a moderate or high level of heterogeneity?

Mixed effect model

Fixed effect model

Random effect model (correct)

Bayesian model

Why is it better to present conservative results in meta-analyses?

To demonstrate consistency between studies

To account for variability within each experiment

To showcase diverse methodologies

Since many trials have different methodologies and patient populations (correct)

How can you determine consistency between studies in a meta-analysis?

By assessing the width of the overall pooled effect size

By measuring the heterogeneity within each study

By observing if confidence intervals overlap

By evaluating if the studies fall on the same side of the line of no effect (correct)

What does it indicate if confidence intervals do not overlap in a meta-analysis?

Heterogeneity regardless of the side of the line of no effect Signup and view all the answers

What does a larger confidence interval in a trial suggest in a meta-analysis?

Lower precision and greater uncertainty Signup and view all the answers

If the lines of confidence intervals do not overlap by at least 1/3 in a meta-analysis, what does it suggest?

Presence of inconsistency Signup and view all the answers

What does high heterogeneity in a meta-analysis suggest?

The effect demonstrated is not valid Signup and view all the answers

In meta-analysis, what does a mild heterogeneity percentage typically indicate?

Valid results Signup and view all the answers

How is heterogeneity described in the context of meta-analysis?

Variability between studies Signup and view all the answers

What does it mean if the confidence interval and diamond do not cross the line of no effect in a forest plot?

Improvement in positive outcome Signup and view all the answers

Why is high heterogeneity a concern in meta-analysis?

It may indicate invalid results Signup and view all the answers

What should researchers consider if they encounter over 70% heterogeneity in a meta-analysis?

Not meta-analyzing the results Signup and view all the answers

What does the I2 statistic measure in a meta-analysis?

Consistency of the studies Signup and view all the answers

If the I2 value is greater than 50%, what might this suggest about the studies in a meta-analysis?

The studies are inconsistent due to a reason other than chance Signup and view all the answers

What is a key factor that affects the validity of meta-analysis results?

The quality of the original study-level data Signup and view all the answers

Which model assumes all studies in a meta-analysis estimate the same quantity?

Fixed effect meta-analysis Signup and view all the answers

In a meta-analysis, what does the random effect model take into account that differs from the fixed effect model?

Heterogeneity between studies Signup and view all the answers

When can the fixed effect model be appropriately used in a meta-analysis?

When all studies estimate the same quantity Signup and view all the answers