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Questions and Answers
What is the trade name of Mesalamine?
What is the trade name of Mesalamine?
What is the generic name of Apriso?
What is the generic name of Apriso?
Mesalamine
What is the therapeutic classification of Mesalamine?
What is the therapeutic classification of Mesalamine?
Gastrointestinal anti-inflammatory
What are the indications for Mesalamine?
What are the indications for Mesalamine?
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What is the action of Mesalamine?
What is the action of Mesalamine?
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List two CNS side effects of Mesalamine.
List two CNS side effects of Mesalamine.
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What are some gastrointestinal side effects of Mesalamine?
What are some gastrointestinal side effects of Mesalamine?
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What should be assessed during therapy with Mesalamine?
What should be assessed during therapy with Mesalamine?
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What is an important implementation instruction for taking Mesalamine orally?
What is an important implementation instruction for taking Mesalamine orally?
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What should patients be instructed regarding the method of administration of Mesalamine?
What should patients be instructed regarding the method of administration of Mesalamine?
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Study Notes
Mesalamine Overview
- Trade name: Apriso
- Generic name: Mesalamine
- Therapeutic classification: Gastrointestinal anti-inflammatory
Indications
- Used for treatment and maintenance of remission in mildly to moderately active ulcerative colitis
Mechanism of Action
- Acts locally in the colon with anti-inflammatory properties, likely by inhibiting prostaglandin synthesis
Side Effects
- CNS: Headache, dizziness, malaise, weakness
- EENT: Pharyngitis, rhinitis
- CV: Pericarditis
- GI: Diarrhea, eructation, flatulence, nausea, vomiting
- GU: Interstitial nephritis, pancreatitis, renal failure
- Dermatological: Stevens-Johnson syndrome, hair loss, rash
- Local: Anal irritation from enema administration
- Musculoskeletal: Back pain, myalgia
- Miscellaneous: Anaphylaxis, angioedema, drug reaction with eosinophilia and systemic symptoms
Assessment Considerations
- Evaluate abdominal pain and monitor stool frequency, quantity, and consistency at initiation and during therapy
- Check for allergies to sulfonamides and salicylates
- Monitor intake and output ratios
- Conduct urinalysis, BUN, and serum creatinine assessments
- Drug may elevate levels of AST, ALT, alkaline phosphate, GGTP, LDH, amylase, and lipase
Implementation Guidelines
- Oral administration should be with a full glass of water; do not crush the medication
- For rectal form, ensure bowel is emptied prior to administration
- Limit handling of suppository
- Administer 60 ml retention enema once daily at bedtime; retain solution for approximately 8 hours
Client Teaching Points
- Educate on the correct administration method
- Stress the importance of adhering to prescribed dosing
- Advise against changing medication brand without consulting healthcare provider
- Caution patients about potential dizziness affecting driving ability
- Instruct to report any skin rash, sore throat, wheezing, fever, or hives, especially if symptoms persist beyond 1-2 months
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Description
This quiz serves as a set of flashcards focusing on Mesalamine, including its trade name, generic name, therapeutic classification, indications, and mechanism of action. It's a useful tool for students and professionals looking to enhance their understanding of this gastrointestinal anti-inflammatory medication.
