Mesalamine Flashcards

Mesalamine Overview

• Trade name: Apriso
• Generic name: Mesalamine
• Therapeutic classification: Gastrointestinal anti-inflammatory

Indications

• Used for treatment and maintenance of remission in mildly to moderately active ulcerative colitis

Mechanism of Action

• Acts locally in the colon with anti-inflammatory properties, likely by inhibiting prostaglandin synthesis

Side Effects

• CNS: Headache, dizziness, malaise, weakness
• EENT: Pharyngitis, rhinitis
• CV: Pericarditis
• GI: Diarrhea, eructation, flatulence, nausea, vomiting
• GU: Interstitial nephritis, pancreatitis, renal failure
• Dermatological: Stevens-Johnson syndrome, hair loss, rash
• Local: Anal irritation from enema administration
• Musculoskeletal: Back pain, myalgia
• Miscellaneous: Anaphylaxis, angioedema, drug reaction with eosinophilia and systemic symptoms

Assessment Considerations

• Evaluate abdominal pain and monitor stool frequency, quantity, and consistency at initiation and during therapy
• Check for allergies to sulfonamides and salicylates
• Monitor intake and output ratios
• Conduct urinalysis, BUN, and serum creatinine assessments
• Drug may elevate levels of AST, ALT, alkaline phosphate, GGTP, LDH, amylase, and lipase

Implementation Guidelines

• Oral administration should be with a full glass of water; do not crush the medication
• For rectal form, ensure bowel is emptied prior to administration
• Limit handling of suppository
• Administer 60 ml retention enema once daily at bedtime; retain solution for approximately 8 hours

Client Teaching Points

• Educate on the correct administration method
• Stress the importance of adhering to prescribed dosing
• Advise against changing medication brand without consulting healthcare provider
• Caution patients about potential dizziness affecting driving ability
• Instruct to report any skin rash, sore throat, wheezing, fever, or hives, especially if symptoms persist beyond 1-2 months

This quiz serves as a set of flashcards focusing on Mesalamine, including its trade name, generic name, therapeutic classification, indications, and mechanism of action. It's a useful tool for students and professionals looking to enhance their understanding of this gastrointestinal anti-inflammatory medication.