Questions and Answers
What is the trade name of Mesalamine?
What is the generic name of Apriso?
Mesalamine
What is the therapeutic classification of Mesalamine?
Gastrointestinal anti-inflammatory
What are the indications for Mesalamine?
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What is the action of Mesalamine?
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List two CNS side effects of Mesalamine.
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What are some gastrointestinal side effects of Mesalamine?
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What should be assessed during therapy with Mesalamine?
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What is an important implementation instruction for taking Mesalamine orally?
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What should patients be instructed regarding the method of administration of Mesalamine?
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Study Notes
Mesalamine Overview
- Trade name: Apriso
- Generic name: Mesalamine
- Therapeutic classification: Gastrointestinal anti-inflammatory
Indications
- Used for treatment and maintenance of remission in mildly to moderately active ulcerative colitis
Mechanism of Action
- Acts locally in the colon with anti-inflammatory properties, likely by inhibiting prostaglandin synthesis
Side Effects
- CNS: Headache, dizziness, malaise, weakness
- EENT: Pharyngitis, rhinitis
- CV: Pericarditis
- GI: Diarrhea, eructation, flatulence, nausea, vomiting
- GU: Interstitial nephritis, pancreatitis, renal failure
- Dermatological: Stevens-Johnson syndrome, hair loss, rash
- Local: Anal irritation from enema administration
- Musculoskeletal: Back pain, myalgia
- Miscellaneous: Anaphylaxis, angioedema, drug reaction with eosinophilia and systemic symptoms
Assessment Considerations
- Evaluate abdominal pain and monitor stool frequency, quantity, and consistency at initiation and during therapy
- Check for allergies to sulfonamides and salicylates
- Monitor intake and output ratios
- Conduct urinalysis, BUN, and serum creatinine assessments
- Drug may elevate levels of AST, ALT, alkaline phosphate, GGTP, LDH, amylase, and lipase
Implementation Guidelines
- Oral administration should be with a full glass of water; do not crush the medication
- For rectal form, ensure bowel is emptied prior to administration
- Limit handling of suppository
- Administer 60 ml retention enema once daily at bedtime; retain solution for approximately 8 hours
Client Teaching Points
- Educate on the correct administration method
- Stress the importance of adhering to prescribed dosing
- Advise against changing medication brand without consulting healthcare provider
- Caution patients about potential dizziness affecting driving ability
- Instruct to report any skin rash, sore throat, wheezing, fever, or hives, especially if symptoms persist beyond 1-2 months
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Description
This quiz serves as a set of flashcards focusing on Mesalamine, including its trade name, generic name, therapeutic classification, indications, and mechanism of action. It's a useful tool for students and professionals looking to enhance their understanding of this gastrointestinal anti-inflammatory medication.
