Mercury Toxicity Overview
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Questions and Answers

Which treatment is part of the curative options for chronic mercury toxicity?

  • D-penicillamine as a chelation therapy (correct)
  • Hydrochloric acid for oral ingestion
  • Magnesium sulfate for muscle relaxation
  • Lidocaine injections to relieve pain
  • Among the signs of chronic mercury toxicity, which is associated with the central nervous system?

  • Dermatitis with severe itching
  • Renal failure causing oliguria
  • Melanosis of the gums
  • Kinetic tremors indicating cerebellar affection (correct)
  • What is the primary focus for prophylactic treatment of workers exposed to mercury?

  • Immediate detoxification processes
  • Daily medication of pain relievers
  • Weekly blood transfusions to remove heavy metals
  • Periodic medical examinations and proper protective measures (correct)
  • Which symptom is NOT associated with mercurial dysentery in chronic mercury toxicity?

    <p>Mouth ulcers (A)</p> Signup and view all the answers

    Which physiological antidote is specifically mentioned for managing mercury toxicity?

    <p>DMSA, the oral analog of BAL (C)</p> Signup and view all the answers

    What is a common manifestation of chronic mercury poisoning in children exposed to mercurous chloride?

    <p>Pink teeth (D)</p> Signup and view all the answers

    Which of the following clinical presentations is associated with acute mercury toxicity in the gastrointestinal tract?

    <p>Metallic taste (D)</p> Signup and view all the answers

    What type of mercury is particularly toxic to the central nervous system?

    <p>Elemental mercury vapor (C)</p> Signup and view all the answers

    Which substance is known as a disinfectant and is a form of inorganic mercury?

    <p>Mercuric chloride (D)</p> Signup and view all the answers

    What condition can arise from exposure to mercury vapor leading to nervous manifestations?

    <p>Corrosive bronchitis (D)</p> Signup and view all the answers

    Which of the following is a potential cause of death related to acute mercury toxicity?

    <p>Dehydration within 24 hours (B)</p> Signup and view all the answers

    Which type of mercury is known to be incorporated and concentrated in the aquatic food chain?

    <p>Organic mercurial salts (C)</p> Signup and view all the answers

    What does mercury react with that results in cellular enzymatic depression?

    <p>Sulfhydryl groups (D)</p> Signup and view all the answers

    Flashcards

    Mercurialism

    A medical condition caused by long-term exposure to mercury.

    Salivation (Early sign of Mercurialism)

    A common symptom of mercurialism, causing excessive salivation and a silvery line on the gum tissue.

    Chelation Therapy

    A key treatment approach for mercurialism, involving the use of drugs that bind and remove mercury from the body.

    Symptomatic treatment for Mercurialism

    A type of treatment which focuses on managing the specific symptoms of mercurialism.

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    Prophylactic treatment for Mercurialism

    A simple way to help prevent mercurialism, involving regular checkups for workers exposed to mercury.

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    Mercury Toxicity

    Mercury is a heavy metal with various forms, each posing unique toxicity risks. Elemental mercury, found in thermometers and dental fillings, is primarily dangerous upon inhalation, while inorganic salts like calomel can cause poisoning in children when absorbed through the skin, leading to pink teeth and other complications. Organic mercurial salts, often used in fungicides and diuretics, contaminate food chains and are particularly harmful as they accumulate in the environment.

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    Acrodynia (Pink Disease)

    Acrodynia is a condition caused by mercury poisoning, often in children. Exposure to mercurous chloride in lotions or powders leads to absorption and a characteristic pink coloration of the teeth. Other symptoms include insomnia, hypertension, peeling skin, alopecia, pink and painful hands, and potential acute renal failure.

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    Mercury and the CNS

    Mercury vapor, a form of elemental mercury, is particularly toxic to the central nervous system (CNS). Organic mercury compounds, like methyl and ethyl mercury, also severely impact the CNS. These forms are often absorbed through the environment, poisoning the CNS.

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    Inorganic Mercury and the Kidneys

    Inorganic mercuric salts are corrosive and specifically target the kidneys, leading to nephrotoxicity. They cause damage to the renal tubules, leading to kidney failure and other complications.

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    Acute Mercury Toxicity Symptoms

    Mercury poisoning manifests in a variety of ways affecting the gastrointestinal, renal, and respiratory systems. Symptoms include metallic taste, burning sensation in the mouth and stomach, nausea and vomiting, tenesmus (mercurial dysentery), dehydration, acute glomerulonephritis, oliguria, corrosive bronchitis, pulmonary edema, tremors, and increased excitability.

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    Dehydration in Mercury Poisoning

    Dehydration is a primary cause of death in acute mercury toxicity. It occurs within 24 hours due to the combination of nausea, vomiting, and diarrhea which deplete the body of fluids. The digestive system is severely compromised by the poisoning.

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    Renal Failure in Mercury Poisoning

    Acute renal failure (RF) is a significant cause of death happening around 10 days after mercury poisoning. Inorganic mercuric salts specifically target the kidneys, causing damage and dysfunction. This leads to an inability to filter waste products efficiently, causing kidney failure.

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    Treating Mercury Poisoning

    Treatment for acute mercury poisoning involves immediate measures to stabilize the patient and prevent escalation of the condition. Dehydration and electrolyte imbalances need to be corrected promptly. Chelating agents, substances that bind to mercury and facilitate its excretion, are used to remove mercury from the body, reducing tissue damage. Supportive care, including breathing assistance and dialysis in severe cases, is crucial for recovery.

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    Study Notes

    Mercury Toxicity

    • Mercury (Hg), also known as hydrargyrum, is a toxic element.
    • Sources of mercury exposure include elemental mercury (vapour, dental amalgams, thermometers), and inorganic salts (calomel, mercurous chloride).
    • Elemental mercury is toxic only after inhalation.
    • Inorganic salts are poorly absorbed if swallowed.
    • Chronic exposure to inorganic mercury (especially in children from teething lotions or diaper powders) can cause pink teeth, a condition called Acrodynia.
    • Organic mercury salts, like methyl mercury and ethyl mercury, act as diuretics and fungicides.
    • These organic forms are significant environmental contaminants accumulating in the aquatic food chain.

    Mechanism of Action

    • Mercury reacts with sulfhydryl (-SH) groups in cells, suppressing enzymatic mechanisms.
    • Elemental mercury vapor and organic mercury compounds are especially harmful to the central nervous system (CNS).
    • Inorganic mercuric salts are corrosive and toxic to the kidneys.

    Acute Mercury Toxicity - Clinical Presentation

    • Gastrointestinal (GIT): Metallic taste, burning sensation, nausea, blood-tinged vomiting, tenesmus (leading to potentially bloody diarrhea—mercurial dysentery), dehydration and collapsing.
    • Renal: Acute toxic glomerulonephritis leading to reduced urine output (oliguria), presence of protein and blood in the urine (albumin and blood casts), and possible kidney failure (anuria and renal failure).
    • Respiratory: Corrosive bronchitis leading to pulmonary edema (fluid build-up in the lungs). Nervous system symptoms can include tremors and increased excitability.

    Acute Mercury Toxicity - Causes of Death

    • Dehydration can occur within 24 hours.
    • Renal Failure can occur within 10 days.

    Acute Mercury Toxicity - Treatment

    • Immediate action: Remove the exposed person from the source of exposure.
    • Gastric lavage: Using local antidotes like egg whites and skimmed milk (precipitating mercury albuminate) and sodium formaldehyde sulfoxylate as a reducing agent to make the mercury chloride insoluble.

    Chronic Mercury Toxicity - Mercurialism - Clinical Presentation

    • Gastrointestinal (GIT): Salivation (early sign), grey line on the gums, gingivitis (inflammation and swelling of the gums), loose teeth and gangrene (cancrum oris)
    • Renal: Albuminuria (protein in the urine), haematuria (blood in the urine), granular and hyaline casts, oliguria (reduced urine output), and renal failure.
    • Central Nervous System (CNS): Kinetic tremors (cerebellar), Hg erethism (shyness, loss of confidence, vague fears, depression, neurosis), dermatitis, and Mercurialentis (discolouration of eye lens capsule).

    Chronic Mercury Toxicity - Treatment

    • Prophylactic: Regular medical checks for exposed workers, proper ventilation and protective clothing. Ca, Zn, Fe supplements.
    • Curative: Stop further mercury exposure. Physiological antidotes via chelation therapy (D-penicillamine, BAL, DMSA, DMPS), symptomatic treatment (mouth hygiene, tranquilizers, antidotes for salivation).

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    Related Documents

    Mercury Toxicity PDF

    Description

    This quiz explores the toxic effects of mercury, its sources, and mechanisms of action. It highlights how different forms of mercury impact human health and the environment, particularly focusing on neurological and kidney toxicity. Test your knowledge on the dangers of mercury exposure and its implications.

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