Mepolizumab Treatment in Severe Eosinophilic Asthma - Original Article Review

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12 Questions

Which institution is Mark C. Liu affiliated with?

Johns Hopkins Asthma and Allergy Center

Where is the Lung Centre, Institute for Heart and Lung Health located?

Vancouver, BC, Canada

In which country is the Department of Clinical and Experimental Medicine located?

Italy

Which department does Guy G.Brusselle belong to?

Department of Respiratory Medicine

Where is the Department of Respiratory Medicine located?

Ghent University Hospital, Belgium

Which country is Hector G.Ortega affiliated with?

USA

What was the primary outcome measured in the study?

Forced expiratory volume in 1 second (FEV1)

What type of antibody is mepolizumab?

Humanized monoclonal antibody against interleukin-5

How often was mepolizumab or placebo administered to the patients?

Every 4 weeks

What was the purpose of assigning patients to receive either mepolizumab or placebo?

To evaluate the rate of exacerbations

Which questionnaire was used to assess asthma control in the study?

St. George’s Respiratory Questionnaire (SGRQ)

What was the total duration of the study period?

32 weeks

Review questions based on the original article 'Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma' published in The New England Journal of Medicine. Test your understanding of the study conducted by Hector G. Ortega, M.D., and colleagues.

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