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Questions and Answers
What is the change in membrane potential called when it becomes less negative?
What is the change in membrane potential called when it becomes less negative?
What triggers depolarization in a cell?
What triggers depolarization in a cell?
During which phase does the membrane potential return to its normal state after depolarization?
During which phase does the membrane potential return to its normal state after depolarization?
What happens to the cell's interior during hyperpolarization?
What happens to the cell's interior during hyperpolarization?
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What is the threshold in the context of membrane potentials?
What is the threshold in the context of membrane potentials?
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Which ions are primarily involved in repolarization?
Which ions are primarily involved in repolarization?
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Which of the following represents a typical change in membrane potential during an action potential?
Which of the following represents a typical change in membrane potential during an action potential?
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Which process occurs immediately after the depolarization stage in a typical action potential?
Which process occurs immediately after the depolarization stage in a typical action potential?
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What happens during neurotransmission after neurotransmitter binds to postsynaptic receptors?
What happens during neurotransmission after neurotransmitter binds to postsynaptic receptors?
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Which type of synaptic transmission involves the receptor protein also functioning as an ion channel?
Which type of synaptic transmission involves the receptor protein also functioning as an ion channel?
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What characterizes excitatory synapses?
What characterizes excitatory synapses?
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Inhibitory post-synaptic potentials (IPSP) are typically permeable to which ions?
Inhibitory post-synaptic potentials (IPSP) are typically permeable to which ions?
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What does the Na/K- ATPase do in terms of ion movement?
What does the Na/K- ATPase do in terms of ion movement?
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What occurs during slow synaptic transmission?
What occurs during slow synaptic transmission?
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Which neurotransmitter is primarily associated with excitatory synapses?
Which neurotransmitter is primarily associated with excitatory synapses?
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How can changes in ion concentration affect membrane potential?
How can changes in ion concentration affect membrane potential?
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What effect does increasing membrane permeability to Na+ have on the membrane potential?
What effect does increasing membrane permeability to Na+ have on the membrane potential?
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Which type of ion channel is influenced by the binding of acetylcholine at the neuromuscular junction?
Which type of ion channel is influenced by the binding of acetylcholine at the neuromuscular junction?
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In which type of gating do channels respond to changes in membrane potential?
In which type of gating do channels respond to changes in membrane potential?
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What is the equilibrium potential for K+ as mentioned in the content?
What is the equilibrium potential for K+ as mentioned in the content?
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What is a characteristic of a ligand-gated channel?
What is a characteristic of a ligand-gated channel?
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What type of channels are involved in action potentials?
What type of channels are involved in action potentials?
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What happens when K+ or Cl- channels are opened?
What happens when K+ or Cl- channels are opened?
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What is the role of the presynaptic neurone in a synapse?
What is the role of the presynaptic neurone in a synapse?
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Flashcards
Depolarization
Depolarization
A decrease in the size of the membrane potential from its normal value. The cell interior becomes less negative.
Hyperpolarization
Hyperpolarization
An increase in the size of the membrane potential from its normal value. The cell interior becomes more negative.
Repolarization
Repolarization
The return of the membrane potential to its resting value after depolarization or hyperpolarization.
Threshold
Threshold
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Sodium Influx
Sodium Influx
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Potassium Efflux
Potassium Efflux
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Action Potential
Action Potential
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Resting Membrane Potential
Resting Membrane Potential
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Voltage-Gated Sodium Channel
Voltage-Gated Sodium Channel
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Voltage-Gated Potassium Channel
Voltage-Gated Potassium Channel
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Membrane Potential
Membrane Potential
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Equilibrium Potential
Equilibrium Potential
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Ligand-Gated Channel
Ligand-Gated Channel
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Synaptic Transmission
Synaptic Transmission
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Presynaptic Neuron
Presynaptic Neuron
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Postsynaptic Neuron
Postsynaptic Neuron
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What is neurotransmission?
What is neurotransmission?
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What is a synapse?
What is a synapse?
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Where do synaptic connections occur?
Where do synaptic connections occur?
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What is fast synaptic transmission?
What is fast synaptic transmission?
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What are excitatory synapses?
What are excitatory synapses?
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What are inhibitory synapses?
What are inhibitory synapses?
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What are postsynaptic potentials?
What are postsynaptic potentials?
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What is slow synaptic transmission?
What is slow synaptic transmission?
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Study Notes
Membranes and Receptors - Session 3
- This lecture focuses on the resting cell membrane and changing membrane potentials.
- The lecturer is Dr. Safa Amir.
- Changes in membrane potential are fundamental to cell signaling, both between and within cells.
Changing Membrane Potentials
- Examples of processes involving changing membrane potentials:
- Action potentials in nerve and muscle cells
- Muscle contraction initiation and regulation
- Hormone and neurotransmitter secretion control
- Sensory information transduction into electrical signals
- Synaptic transmission (especially fast synaptic transmission)
- Depolarization: A decrease in membrane potential from its normal value, making the cell interior less negative.
- Example: A change from -70 mV to -50 mV.
- Hyperpolarization: An increase in membrane potential from its normal value, making the cell interior more negative.
- Example: A change from -70 mV to -90 mV.
Voltage-Gated Sodium Channels
- Sodium ion channels are involved in action potential generation.
- The specific ion channels have different stages:
- Inactivated
- Activation gate
- Inactivation gate
- Resting
Voltage-Gated Potassium Channels
- Potassium channels are also crucial for action potentials and return to the resting state. Like sodium channels, these can be categorized in different states.
- Resting
- Slow activation
Action Potential Summary
- This graph shows the voltage changes over time in an action potential.
- Key stages to remember:
- Depolarization
- Repolarization
- Refractory Period.
Changing Membrane Ion Permeability
- Membrane permeability changes influence the membrane potential according to the equilibrium potential of the ions.
- Equilibrium potentials for specific ions (important in determining permeability) :
- K+: -95 mV
- Na+: +70 mV
- Ca2+: +122 mV
- Cl-: -96 mV
- Changes in membrane potential arise from changes in ion channel activity.
Nicotinic Acetylcholine Receptors
- These receptors are found at neuromuscular junctions.
- They have an intrinsic ion channel and open in response to acetylcholine.
- They allow both sodium (Na+) and potassium (K+) ions to pass but not anions.
- They shift membrane potential toward 0 mV, intermediate between ENa and EK.
Controlling Channel Activity
- Channels can be gated (open or close in response to stimuli).
- Types of gating:
- Ligand Gating: Channels respond to the binding of chemical ligands, like neurotransmitters or hormones. (e.g., at synapses)
- Voltage Gating: Channels open or close in response to changes in membrane potential, as in action potentials.
- Mechanical Gating: Channels respond to mechanical forces that stretch or deform the membrane.
Synaptic Transmission
- Synapses are gaps between neurons or neurons and other cells (e.g., muscle cells, gland cells) allowing signal transmission.
- A signal travels from the pre-synaptic neuron, across the synapse using neurotransmitters to the postsynaptic neuron.
- Starts with neurotransmitter release from the pre-synaptic neuron to connect with receptors on the post-synaptic membranes.
- Neurotransmitters are removed after their task to allow another transmission cycle.
Fast Synaptic Transmission
- In fast synaptic transmission, the receptor protein is an ion channel.
- Neurotransmitter binding opens the channel, allowing ion flow and altering the postsynaptic membrane potential
Excitatory and Inhibitory Synapses
- Excitatory Postsynaptic Potentials (EPSPs): Excitatory transmitters depolarize the postsynaptic membrane. (e.g., Glutamate, some types of acetylcholine).
- Inhibitory Postsynaptic Potentials (IPSPs): Inhibitory transmitters hyperpolarize the postsynaptic cell membrane (e.g., GABA, glycine).
Postsynaptic Potentials
- Postsynaptic potentials (PSPs) can be excitatory or inhibitory.
Slow Synaptic Transmission
- Receptors and channels are separate proteins.
- Types:
- Direct G-protein gating
- Gating via an intracellular messenger (like Receptor G-protein Channel)
Other Factors Affecting Membrane Potential
- Changes in ion concentration (particularly extracellular potassium) can affect membrane excitability.
- Electrogenic pumps (e.g., Na+/K+ ATPase) contribute to membrane potential directly in some cells.
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Description
Explore the dynamics of resting cell membranes and changing membrane potentials in this lecture by Dr. Safa Amir. Understand how these changes are critical for cell signaling in various biological processes, including muscle contractions and synaptic transmission.