Membranes and Receptors - Session 2
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What characteristic of phospholipids allows them to form a bilayer in the cell membrane?

  • Phosphate groups are hydrophobic.
  • Fatty acid tails are hydrophilic.
  • Both heads and tails are nonpolar.
  • Phosphate heads are hydrophilic and fatty acid tails are hydrophobic. (correct)
  • Which of the following best describes the permeability of the cell membrane?

  • It is impermeable to both polar and nonpolar substances.
  • It restricts polar molecules while allowing nonpolar molecules to easily cross. (correct)
  • It is only permeable to small nonpolar molecules.
  • It allows all substances to pass freely.
  • What role do proteins play in the uptake and extrusion of specific molecules in the cell membrane?

  • They create the membrane structure.
  • They mediate the transport of specific water molecules and ions. (correct)
  • They ensure that the membrane remains impermeable.
  • They act as permeability barriers for all substances.
  • What is the thickness of the typical cell membrane?

    <p>8 nm (B)</p> Signup and view all the answers

    Which statement is true regarding the separation provided by the cell membrane?

    <p>It defines the cell by controlling traffic in and out based on polarity. (B)</p> Signup and view all the answers

    What primarily drives secondary active transport in cells?

    <p>Ionic concentration differences created by primary active transport (C)</p> Signup and view all the answers

    What is the function of antiporters in active transport?

    <p>Move two molecules in opposite directions (C)</p> Signup and view all the answers

    In the context of active transport, symporters are used to...

    <p>Transport two molecules in the same direction (C)</p> Signup and view all the answers

    Which process connects the active transport of one solute to the transport of other solutes?

    <p>Cotransport (A)</p> Signup and view all the answers

    What role do proton pumps play in the active transport of nutrients in plants?

    <p>They create a gradient of hydrogen ions that drives nutrient transport. (A)</p> Signup and view all the answers

    The Na+-glucose co-transport system primarily exemplifies which type of transport mechanism?

    <p>Secondary active transport using a symporter (D)</p> Signup and view all the answers

    What is the outcome of phosphorylation during active transport?

    <p>Change in the configuration of the carrier protein (B)</p> Signup and view all the answers

    Which statement best describes the role of carrier proteins in active transport?

    <p>They facilitate the transport of specific solutes across the cell membrane. (D)</p> Signup and view all the answers

    What primarily characterizes a semi-permeable membrane in a cell?

    <p>Specific channels permit certain materials across (D)</p> Signup and view all the answers

    What is the function of aquaporin in bacteria?

    <p>Transport water across the cell membrane (B)</p> Signup and view all the answers

    Which of the following correctly describes passive transport?

    <p>Involves movement from high to low concentration (C)</p> Signup and view all the answers

    What distinguishes facilitated diffusion from simple diffusion?

    <p>Facilitated diffusion requires transport proteins (C)</p> Signup and view all the answers

    What is required for active transport to occur?

    <p>Conformational change in a protein pump (D)</p> Signup and view all the answers

    Which type of transport directly uses energy from ATP?

    <p>Primary active transport (A)</p> Signup and view all the answers

    How does a protein channel function during facilitated diffusion?

    <p>It changes shape to allow solutes to pass (B)</p> Signup and view all the answers

    Which of the following best defines osmosis?

    <p>Diffusion of water through a semi-permeable membrane (D)</p> Signup and view all the answers

    What role do protein pumps play in the cell membrane?

    <p>They transport substances against concentration gradients (D)</p> Signup and view all the answers

    Which statement about diffusion is true?

    <p>It occurs until equilibrium is reached (D)</p> Signup and view all the answers

    Flashcards

    Cell Membrane Barrier

    The cell membrane acts as a barrier, controlling the movement of substances into and out of the cell. It allows some substances to pass through more easily than others.

    Phospholipid Bilayer

    The cell membrane is composed of a phospholipid bilayer. The head of the phospholipid is hydrophilic, attracted to water, while the tail is hydrophobic, repelled by water.

    Hydrophilic Barrier

    Hydrophilic molecules, such as water and sugars, have a hard time crossing the cell membrane because the hydrophobic tails of the phospholipids repel them.

    Hydrophobic Passage

    Hydrophobic molecules, like lipids, can easily pass through the cell membrane because they can interact with the hydrophobic tails of the phospholipids.

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    Thin and Selective

    The cell membrane is very thin, only 8 nanometers thick, which makes it a highly selective barrier.

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    Diffusion

    The movement of molecules from an area of high concentration to an area of low concentration. This process is passive, meaning it does not require energy.

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    Facilitated Diffusion

    A type of diffusion where molecules pass through specific protein channels embedded in the cell membrane. This process is also passive.

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    Osmosis

    The movement of water across a selectively permeable membrane from a region of high water concentration to a region of low water concentration.

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    Active transport

    The movement of molecules across a cell membrane against their concentration gradient. This requires energy, usually in the form of ATP.

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    Primary active transport

    A type of active transport where the energy source to move molecules across the membrane is directly from the breakdown of ATP.

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    Transmembrane protein

    A protein that spans the cell membrane, creating a channel that allows specific molecules to pass through.

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    Aquaporin

    A protein channel that allows water molecules to pass through the cell membrane.

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    Proton pump

    A protein channel that allows protons (H+) to pass through the cell membrane.

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    Semi-permeability

    The ability of a cell membrane to allow certain molecules to pass through while preventing others.

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    Conformational change

    A change in the shape of a protein, often used for transporting molecules across a membrane.

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    Secondary Active Transport

    Energy derived from pre-existing concentration differences across a membrane, established by primary active transport.

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    Uniporter

    Transports one molecule at a time across the membrane.

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    Symporter

    Moves two molecules in the same direction across the membrane.

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    Antiporter

    Moves two molecules in opposite directions across the membrane.

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    Cotransport

    The movement of one solute indirectly drives the transport of other solutes across the membrane.

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    Symport

    A specific type of cotransport where both solutes move in the same direction.

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    Antiport

    A specific type of cotransport where two solutes move in opposite directions.

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    Study Notes

    Membranes and Receptors - Session 2

    • Lecture Objectives: Describe the function of membranes as permeability barriers to small, hydrophilic molecules. Explore protein-mediated mechanisms allowing the uptake and extrusion of specific water molecules and ions.

    Body Fluids

    • Intracellular Fluid: Fluid within cells.
    • Extracellular Fluid: Fluid outside of cells.
      • Intravascular fluid: Blood plasma.
      • Interstitial fluid: Fluid surrounding cells.

    The Cell Membrane

    • Structure: The cell membrane is a thin barrier (8nm thick) that separates the living cell from the aqueous environment. It's primarily composed of a phospholipid bilayer with embedded proteins.

    Phospholipids

    • Structure: Phospholipids have a hydrophilic head (attracted to water) and hydrophobic tails (repelled by water).
    • Arrangement: These arrange themselves as a bilayer, with hydrophobic tails facing inwards and hydrophilic heads facing outwards.

    Phospholipid Bilayer

    • Boundary: This structure serves as a border defining the cell.
    • Impermeability: The bilayer is largely impermeable to polar molecules (e.g., water, sugar, ions) but permeable to nonpolar molecules (e.g., lipids).

    Cell Membrane Function

    • Separation: The cell membrane separates the interior of the cell from its surroundings.
    • Regulation: The cell membrane controls what enters and exits the cell. Hydrophobic (nonpolar) molecules can pass through more readily than hydrophilic (polar) molecules.
    • Thickness: The membrane is approximately 8 nanometers thick.

    Permeability to Polar Molecules

    • Semi-permeable: The membrane becomes semi-permeable due to protein channels.
    • Specific Channels: Specific protein channels allow the passage of specific materials across the membrane (e.g., water, ions, amino acids).

    Cell Membrane Components

    • Transmembrane Proteins: Transmembrane proteins embedded in the bilayer create semi-permeable channels.
    • Lipid Bilayer Membrane: The foundation of the cell membrane.

    Examples of Membrane Proteins

    • Aquaporins: Water channels found in bacteria.
    • Porins: Channels in bacterial outer membranes.
    • Proton Pump (channels): Found in photosynthetic bacteria, these proteins facilitate movement of ions by changing shape.

    Movement Across the Cell Membrane

    • Diffusion: Movement of substances from high to low concentration. This can be both simple (through the lipid bilayer) or facilitated (through protein channels). Water moves through osmosis.
    • Lipid Diffusion: Fats and other lipids can cross directly without the help of a protein.
    • Facilitated Diffusion: Movement of polar or charged molecules through channels that require no energy input.
    • Active Transport: Movement of molecules against their concentration gradient, which requires ATP.

    Types of Active Transport

    • Primary Active Transport: Requires ATP directly for transport, such as the sodium-potassium pump.
    • Secondary Active Transport (Cotransport): The energy is derived secondarily from ionic concentration gradients created by primary active transport. In this process, two or more molecules move together.
      • Symport: Two molecules move in the same direction.
      • Antiport: Two molecules move in opposite directions.
        • Examples: Na+-glucose co-transport or Na+-Ca2+ exchange

    Uniport, Symport and Antiport

    • Uniport: Moves one molecule across the membrane.
    • Symport: Moves two molecules in the same direction across the membrane.
    • Antiport: Moves two molecules in opposite directions across the membrane.

    Additional Notes

    • Diffusion: Movement of molecules from high to low concentration. This occurs naturally across a membrane.
    • Concentration Gradient: Difference in the concentration of a substance across a membrane.

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    Description

    This quiz covers the function of membranes as barriers to hydrophilic molecules and the mechanisms for the uptake and extrusion of water and ions. It includes details about intracellular and extracellular fluids, as well as the structure of cell membranes and phospholipids.

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