Membrane Transporters and Drug Response

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Which of the following is true about membrane transporters in pharmacokinetics?

They function in the pathogenesis of neuropsychiatric disorders

They enhance the efflux of hydrophobic drugs

They decrease the uptake of drugs

They are involved in the selective absorption and elimination of drugs (correct)

Which transporter is overexpressed in tumor cells after exposure to cytotoxic anticancer agents?

Influx transporters

MRP4

Efflux transporters

BCRP (ABCG2) (correct)

What is the consequence of decreased expression of influx transporters required for certain drugs to access the tumor?

Decreased drug uptake (correct)

Enhanced drug efflux

Increased drug resistance

Selective absorption of drugs

Which category of adverse drug responses is associated with decreased uptake or excretion at clearance organs?

Category 1 Signup and view all the answers

Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?

MRP4 Signup and view all the answers

Which of the following is NOT a function of membrane transporters in pharmacokinetics?

Selective absorption of endogenous substances Signup and view all the answers

Which of the following drug classes is NOT associated with decreased uptake mediated by reduced expression of influx transporters?

Antiviral nucleoside analogues Signup and view all the answers

Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?

BCRP (ABCG2) Signup and view all the answers

Which category of adverse drug responses is associated with increased efflux of hydrophobic drugs?

Increased efflux at clearance organs Signup and view all the answers

What is the consequence of reduced expression of influx transporters required for certain drugs to access the tumor?

Decreased efficacy of drugs Signup and view all the answers

Membrane Transporters and Drug Response

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Questions and Answers

Which of the following is true about membrane transporters in pharmacokinetics?

Which transporter is overexpressed in tumor cells after exposure to cytotoxic anticancer agents?

What is the consequence of decreased expression of influx transporters required for certain drugs to access the tumor?

Which category of adverse drug responses is associated with decreased uptake or excretion at clearance organs?

Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?

Which of the following is NOT a function of membrane transporters in pharmacokinetics?

Which of the following drug classes is NOT associated with decreased uptake mediated by reduced expression of influx transporters?

Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?

Which category of adverse drug responses is associated with increased efflux of hydrophobic drugs?

What is the consequence of reduced expression of influx transporters required for certain drugs to access the tumor?

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