Podcast
Questions and Answers
Which of the following is true about membrane transporters in pharmacokinetics?
Which of the following is true about membrane transporters in pharmacokinetics?
- They function in the pathogenesis of neuropsychiatric disorders
- They enhance the efflux of hydrophobic drugs
- They decrease the uptake of drugs
- They are involved in the selective absorption and elimination of drugs (correct)
Which transporter is overexpressed in tumor cells after exposure to cytotoxic anticancer agents?
Which transporter is overexpressed in tumor cells after exposure to cytotoxic anticancer agents?
- Influx transporters
- MRP4
- Efflux transporters
- BCRP (ABCG2) (correct)
What is the consequence of decreased expression of influx transporters required for certain drugs to access the tumor?
What is the consequence of decreased expression of influx transporters required for certain drugs to access the tumor?
- Decreased drug uptake (correct)
- Enhanced drug efflux
- Increased drug resistance
- Selective absorption of drugs
Which category of adverse drug responses is associated with decreased uptake or excretion at clearance organs?
Which category of adverse drug responses is associated with decreased uptake or excretion at clearance organs?
Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?
Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?
Which of the following is NOT a function of membrane transporters in pharmacokinetics?
Which of the following is NOT a function of membrane transporters in pharmacokinetics?
Which of the following drug classes is NOT associated with decreased uptake mediated by reduced expression of influx transporters?
Which of the following drug classes is NOT associated with decreased uptake mediated by reduced expression of influx transporters?
Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?
Which transporter is associated with resistance to antiviral nucleoside analogues when overexpressed?
Which category of adverse drug responses is associated with increased efflux of hydrophobic drugs?
Which category of adverse drug responses is associated with increased efflux of hydrophobic drugs?
What is the consequence of reduced expression of influx transporters required for certain drugs to access the tumor?
What is the consequence of reduced expression of influx transporters required for certain drugs to access the tumor?
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