Meiosis and Reproductive Biology

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Questions and Answers

What is the primary cause of menopause?

  • Increased body weight
  • Hormonal imbalance due to stress
  • Depletion of ovarian follicles (correct)
  • Excessive exercise

What is the purpose of Tamoxifen in medical treatment?

  • To prevent osteoporosis
  • To block estrogen receptors in breast tissue (correct)
  • To increase estrogen production
  • To promote ovulation

Which contraceptive method is a form of permanent sterilization?

  • Condoms
  • Vasectomy (correct)
  • Hormonal pills
  • IUDs

What are common symptoms of Polycystic Ovary Syndrome (PCOS)?

<p>Irregular periods and ovarian cysts (A)</p> Signup and view all the answers

How does Raloxifene primarily function in the body?

<p>As a selective estrogen receptor modulator (SERM) (C)</p> Signup and view all the answers

Which of the following statements about vasectomy is true?

<p>It leads to sterility without affecting hormone levels (C)</p> Signup and view all the answers

What type of contraceptive is a condom?

<p>Barrier method (B)</p> Signup and view all the answers

What can insulin resistance in women with PCOS lead to?

<p>Weight gain (A)</p> Signup and view all the answers

Which of the following is NOT a type of hormonal contraceptive?

<p>Condoms (B)</p> Signup and view all the answers

What is a primary effect of lifestyle changes in managing PCOS symptoms?

<p>Improved insulin sensitivity (A)</p> Signup and view all the answers

What is the primary function of crossing over during Prophase I of meiosis?

<p>To exchange genetic material between homologous chromosomes (A)</p> Signup and view all the answers

What cellular structure is responsible for motility in sperm?

<p>Tail (flagellum) (B)</p> Signup and view all the answers

Which stage of meiosis results in the formation of haploid cells?

<p>Telophase I (A)</p> Signup and view all the answers

What is the consequence of improper chromosome segregation during meiosis?

<p>Aneuploidy or infertility (D)</p> Signup and view all the answers

At what stage does meiosis I complete in females?

<p>During ovulation (B)</p> Signup and view all the answers

What initiates the hormonal regulation of the female menstrual cycle?

<p>Gonadotropin-releasing hormone (GnRH) (D)</p> Signup and view all the answers

How many chromosome combinations can humans produce due to independent assortment during meiosis?

<p>2^23 (D)</p> Signup and view all the answers

What role do sustentacular (Sertoli) cells play in spermatogenesis?

<p>They provide structural support and nourishment to developing sperm (B)</p> Signup and view all the answers

Where does fertilization of an egg typically occur?

<p>Fallopian tube (C)</p> Signup and view all the answers

Which of the following hormones primarily stimulates spermatogenesis in males?

<p>Testosterone (A)</p> Signup and view all the answers

Flashcards

Meiosis stages

A two-part cell division process that reduces the chromosome number in gametes (sex cells).

Spermatogenesis

The process of sperm cell formation from spermatogonia in the seminiferous tubules.

Oogenesis

The process of egg cell formation, beginning in fetal life. One mature egg cell formed per cycle.

Sperm exit path

Sperm travel from epididymis, through vas deferens, ejaculatory duct, to urethra.

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Fertilization location

Fertilization occurs in the fallopian tube.

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Pap smear

A diagnostic test for abnormal cells in the cervix, aiding in early detection of cervical cancer.

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Aneuploidy

Chromosome number disorders (e.g., Down syndrome, Turner syndrome), caused by meiosis errors.

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Sperm structure

Sperm has head (nucleus, acrosome), midpiece (mitochondria), and tail (flagellum).

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Male hormone

Testosterone stimulates sperm production (spermatogenesis).

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Chromosome combinations

There are 2²³ possible chromosome combinations in humans due to independent assortment.

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Menopause definition

Permanent end of menstruation due to ovarian follicle depletion, typically 45-55 years of age.

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Tamoxifen use

Blocks estrogen receptors in breast tissue, to treat breast cancer.

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Raloxifene function

SERM, used to prevent osteoporosis and act on estrogen receptors.

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Vasectomy effect

Surgical procedure that prevents sperm from reaching ejaculate.

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PCOS symptom: Irregular periods

A characteristic sign of PCOS, menstrual cycle irregularities.

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PCOS symptom: Excess androgen

Hormonal imbalance causing acne and hair growth changes.

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PCOS symptom: Ovarian cysts

Cysts that develop on the ovaries, often associated with PCOS.

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PCOS symptom: Insulin resistance

Cells resist insulin's actions, leading to higher blood sugar levels.

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Contraceptive methods: types

Barrier methods, hormonal methods, IUDs, and sterilization methods.

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Contraceptive method: Barrier methods

Methods that physically prevent sperm from reaching the egg.

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Study Notes

Meiosis Stages

  • Prophase I: Homologous chromosomes pair and exchange genetic material (crossing over).
  • Metaphase I: Homologous pairs align at the cell equator.
  • Anaphase I: Homologous chromosomes are pulled to opposite poles.
  • Telophase I: Two haploid cells form, each with half the number of chromosomes.
  • Prophase II: Chromosomes condense again without DNA replication.
  • Metaphase II: Chromosomes align at the equator.
  • Anaphase II: Sister chromatids are separated.
  • Telophase II: Four haploid gametes are formed.

Meiosis Errors

  • Errors in meiosis can cause aneuploidy (e.g., Down syndrome, Turner syndrome) or infertility.

Pap Smear

  • A diagnostic test for abnormal cells in the cervix, used to detect cervical cancer or precancerous conditions.

Sperm Structure and Spermatogenesis

  • Head: Nucleus (DNA) and acrosome (fertilization enzymes).
  • Midpiece: Mitochondria for energy.
  • Tail: Flagellum for motility.
  • Spermatogenesis: Sperm formation in seminiferous tubules, starting with spermatogonia and ending with spermatozoa.

Oogenesis Stages

  • Begins in fetal life with oogonia developing into primary oocytes.
  • Meiosis I completes during ovulation, forming a secondary oocyte.
  • Meiosis II completes upon fertilization, forming a mature ovum.

Sperm Exit Path

  • Epididymis → Vas deferens → Ejaculatory duct → Urethra

Fertilization and Early Embryo Development

  • Fertilization occurs in the fallopian tube.
  • Zygote → Morula → Blastocyst → Embryo.

Gamete Production Comparison

  • Male: Continuous sperm production after puberty.
  • Female: Fixed number of oocytes at birth; one matures per cycle.

Chromosome Combinations

  • Humans have 2²³ possible chromosome combinations due to independent assortment.

Reproductive Hormones

  • Male: Testosterone (stimulates spermatogenesis).
  • Female: Estrogen, progesterone, FSH, and LH regulate the menstrual cycle and ovulation.

Sustentacular Cell Function

  • Sustentacular (Sertoli) cells are crucial for spermatogenesis. Damage impairs sperm production, leading to infertility.

Menopause

  • Permanent cessation of menstruation due to ovarian follicle depletion, typically between ages 45-55.

Tamoxifen and Raloxifene

  • Tamoxifen: Blocks estrogen receptors in breast tissue, used for breast cancer treatment.
  • Raloxifene: A selective estrogen receptor modulator (SERM) used for osteoporosis prevention.

Contraceptives

  • Barrier methods: Condoms
  • Hormonal methods: Birth control pills, implants
  • Intrauterine devices (IUDs)
  • Sterilization: Vasectomy, tubal ligation

Vasectomy Effects

  • Vasectomy prevents sperm from reaching the ejaculate by blocking the vas deferens, resulting in sterility without affecting hormone levels.

PCOS Symptoms

  • Irregular periods.
  • Excess androgens (acne, hair growth).
  • Ovarian cysts.
  • Insulin resistance and weight gain.

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