Megaloblastic Anemia: B12 and Folate Deficiencies
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Questions and Answers

Which vitamin is involved in the conversion of Homocysteine to Methionine?

  • Vitamin D
  • Vitamin C
  • Vitamin B12 (correct)
  • Vitamin K
  • Which form of vitamin B12 is the main form in human plasma?

  • Methylcobalamin (correct)
  • Cyanocobalamin
  • Hydroxocobalamin
  • Deoxyadenosylcobalamin
  • What are the main forms of vitamin B12 in tissues?

  • Deoxyadenosylcobalamin (correct)
  • Cyanocobalamin
  • Hydroxocobalamin
  • Methylcobalamin
  • Which nutrient is essential for maintaining the active form of folate inside the cells?

    <p>Vitamin B12 (D)</p> Signup and view all the answers

    What is the main cause of megaloblastic anemia according to the given information?

    <p>Vitamin B12 deficiency (C)</p> Signup and view all the answers

    What is the most common cause of folate deficiency?

    <p>Reduced intake in strict vegetarians (C)</p> Signup and view all the answers

    Which condition is characterized by a combination of megaloblastic anemia, glossitis, and neuropathy?

    <p>Pernicious anemia (A)</p> Signup and view all the answers

    Which form of folic acid is the most important in body fluids?

    <p>Methyltetrahydrofolate monoglutamate (A)</p> Signup and view all the answers

    What is the main cause of cobalamin deficiency in the elderly?

    <p>Gastrectomy (C)</p> Signup and view all the answers

    Which blood cell abnormality is commonly seen in megaloblastic anemia?

    <p>Normochromic, macrocytosis (C)</p> Signup and view all the answers

    Which clinical feature is NOT associated with cobalamin deficiency?

    <p>Sterility (A)</p> Signup and view all the answers

    What is the most common cause of folate deficiency?

    <p>Reduced intake (D)</p> Signup and view all the answers

    What is the main form of vitamin B12 in human plasma?

    <p>Cyanocobalamin (D)</p> Signup and view all the answers

    Which condition is characterized by a combination of megaloblastic anemia, glossitis, and neuropathy?

    <p>Pernicious anemia (B)</p> Signup and view all the answers

    What is the best known megaloblastic anemia due to cobalamin deficiency?

    <p>Pernicious anemia (B)</p> Signup and view all the answers

    What is the main function of vitamin B12 in the conversion of Homocysteine to Methionine?

    <p>Maintaining the active form of folate inside the cells (D)</p> Signup and view all the answers

    Which form of vitamin B12 is primarily utilized in the treatment of B12 deficiency?

    <p>Hydroxocobalamin (D)</p> Signup and view all the answers

    What happens to Homocysteine when Vitamin B12 is not available to maintain the active form of folate?

    <p>It accumulates and leads to cardiovascular diseases (D)</p> Signup and view all the answers

    What is the main function of folate inside the cells that is important for DNA synthesis?

    <p>Serving as a precursor for nucleotide synthesis (D)</p> Signup and view all the answers

    Why is megaloblastic anemia characterized by distinctive abnormalities in blood and marrow?

    <p>Impaired DNA synthesis affects the maturation of blood cells (A)</p> Signup and view all the answers

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