Questions and Answers
What is the classification of medroxyPROGESTERone acetate?
What is the generic name of medroxyPROGESTERone acetate?
medroxyPROGESTERone acetate
Which of the following is a trade name for medroxyPROGESTERone acetate?
What is the action of medroxyPROGESTERone acetate?
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What are the indications for the use of medroxyPROGESTERone acetate?
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What are the available forms of medroxyPROGESTERone acetate?
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Which of the following is a common adverse effect of medroxyPROGESTERone acetate?
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What interaction might occur with medroxyPROGESTERone acetate?
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Which of the following is a contraindication for medroxyPROGESTERone acetate?
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Study Notes
Classification
- Prototype progestin used in therapy
- Therapeutic class: Estrogens
- Pharmacologic class: Progestins, antineoplastic, hormone, contraceptive
Generic Name
- MedroxyPROGESTERone acetate
Trade Names
- Commonly known as Depo-Provera, Depo-subQ Provera 104, Meprogest, and Provera
Mechanism of Action
- Suppresses ovulation by potentially inhibiting pituitary gonadotropin secretion
- Prevents follicular maturation and causes thinning of the endometrium
Indications for Use
- Treats menstrual disorders and endometriosis
- Utilized in cases of endometrial carcinoma
Route and Dosage
- Forms include injectable suspensions (104 mg/0.65 mL, 150 mg/mL, 400 mg/mL) and oral tablets (2.5 mg, 5 mg, 10 mg)
- Injection: administer deep intramuscularly in gluteal or deltoid muscles; monitor for pain and rotate sites to prevent atrophy
- Subcutaneous injections: require vigorous shaking before use; given over 5 to 7 seconds into the thigh or abdomen
- Caution necessary as it's classified as a hazardous drug
Adverse Reactions/Side Effects
- Significant risks include cardiovascular complications such as stroke, heart attack, hypertension, and thromboembolic events
- Common side effects: irregular vaginal bleeding, weight gain, and fluid retention
- Other notable side effects may affect various systems, including GI (bloating, nausea), GU (breakthrough bleeding), and metabolic (weight changes)
Drug Interactions
- Certain drugs (e.g., anticonvulsants, corticosteroids) may reduce the efficacy of progestins
- St. John's wort may diminish progestin effects; caution with caffeine and grapefruit due to potential interactions
- Smoking increases CV risk; may require alternative therapy
Contraindications and Precautions
- Contraindications include allergies, pregnancy, and breastfeeding
- Black Box Warning against using estrogens with progestins for CV disease or dementia prevention
- Not recommended for patients with active thromboembolic disorders, history of stroke, or certain cancers
- Caution for long-term use of the injectable form beyond two years without adequate alternatives
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Description
Test your knowledge on Medroxyprogesterone Acetate with these flashcards. Covering classification, generic names, trade names, and pharmacologic actions, these cards are a perfect study tool for students and healthcare professionals alike. Understand the uses and impacts of this important progestin.
