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What is the classification of medroxyPROGESTERone acetate?
What is the classification of medroxyPROGESTERone acetate?
What is the generic name of medroxyPROGESTERone acetate?
What is the generic name of medroxyPROGESTERone acetate?
medroxyPROGESTERone acetate
Which of the following is a trade name for medroxyPROGESTERone acetate?
Which of the following is a trade name for medroxyPROGESTERone acetate?
What is the action of medroxyPROGESTERone acetate?
What is the action of medroxyPROGESTERone acetate?
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What are the indications for the use of medroxyPROGESTERone acetate?
What are the indications for the use of medroxyPROGESTERone acetate?
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What are the available forms of medroxyPROGESTERone acetate?
What are the available forms of medroxyPROGESTERone acetate?
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Which of the following is a common adverse effect of medroxyPROGESTERone acetate?
Which of the following is a common adverse effect of medroxyPROGESTERone acetate?
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What interaction might occur with medroxyPROGESTERone acetate?
What interaction might occur with medroxyPROGESTERone acetate?
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Which of the following is a contraindication for medroxyPROGESTERone acetate?
Which of the following is a contraindication for medroxyPROGESTERone acetate?
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Study Notes
Classification
- Prototype progestin used in therapy
- Therapeutic class: Estrogens
- Pharmacologic class: Progestins, antineoplastic, hormone, contraceptive
Generic Name
- MedroxyPROGESTERone acetate
Trade Names
- Commonly known as Depo-Provera, Depo-subQ Provera 104, Meprogest, and Provera
Mechanism of Action
- Suppresses ovulation by potentially inhibiting pituitary gonadotropin secretion
- Prevents follicular maturation and causes thinning of the endometrium
Indications for Use
- Treats menstrual disorders and endometriosis
- Utilized in cases of endometrial carcinoma
Route and Dosage
- Forms include injectable suspensions (104 mg/0.65 mL, 150 mg/mL, 400 mg/mL) and oral tablets (2.5 mg, 5 mg, 10 mg)
- Injection: administer deep intramuscularly in gluteal or deltoid muscles; monitor for pain and rotate sites to prevent atrophy
- Subcutaneous injections: require vigorous shaking before use; given over 5 to 7 seconds into the thigh or abdomen
- Caution necessary as it's classified as a hazardous drug
Adverse Reactions/Side Effects
- Significant risks include cardiovascular complications such as stroke, heart attack, hypertension, and thromboembolic events
- Common side effects: irregular vaginal bleeding, weight gain, and fluid retention
- Other notable side effects may affect various systems, including GI (bloating, nausea), GU (breakthrough bleeding), and metabolic (weight changes)
Drug Interactions
- Certain drugs (e.g., anticonvulsants, corticosteroids) may reduce the efficacy of progestins
- St. John's wort may diminish progestin effects; caution with caffeine and grapefruit due to potential interactions
- Smoking increases CV risk; may require alternative therapy
Contraindications and Precautions
- Contraindications include allergies, pregnancy, and breastfeeding
- Black Box Warning against using estrogens with progestins for CV disease or dementia prevention
- Not recommended for patients with active thromboembolic disorders, history of stroke, or certain cancers
- Caution for long-term use of the injectable form beyond two years without adequate alternatives
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Description
Test your knowledge on Medroxyprogesterone Acetate with these flashcards. Covering classification, generic names, trade names, and pharmacologic actions, these cards are a perfect study tool for students and healthcare professionals alike. Understand the uses and impacts of this important progestin.
