Medicine Quiz on Common Disorders and Treatments

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Questions and Answers

What is the primary treatment focus for managing GERD?

  • Medications and lifestyle changes (correct)
  • Surgery to correct the esophagus
  • High calorie and protein diet
  • Mechanical interventions for the intestines

Which of the following is among the CFTR modulators approved for therapeutic use?

  • Kalydeco (correct)
  • Trikafta (correct)
  • Lumacaftor
  • All of the above

What is the recommended approach for couples seeking prenatal care when one partner is Caucasian?

  • Biopsy of the placenta
  • No special testing needed
  • Prenatal genetic screening only
  • CF carrier testing is advised (correct)

What treatments are suggested for a female infertility rate affecting 20-35%?

<p>Hormonal therapies and IVF (A)</p> Signup and view all the answers

Which of the following options can be used for the management of the vas deferens being absent?

<p>Artificial insemination with donor sperm (A)</p> Signup and view all the answers

What is the recommended antidote for acetaminophen overdose?

<p>N-Acetylcysteine (A)</p> Signup and view all the answers

Which of the following is NOT a risk factor for developing conjunctivitis?

<p>Recently undergoing surgery (A)</p> Signup and view all the answers

Which type of hemoglobin is most commonly associated with sickle cell anemia?

<p>Hgb SS (C)</p> Signup and view all the answers

What is the purpose of hemoglobin electrophoresis?

<p>To identify the different types of hemoglobin in an individual (A)</p> Signup and view all the answers

Which treatment option is NOT typically used for conjunctivitis?

<p>Antihistamines (D)</p> Signup and view all the answers

What is a significant drawback of intensive therapy for diabetes management?

<p>Hypoglycemia (A)</p> Signup and view all the answers

What is one of the primary benefits of using an insulin pump?

<p>Continuous basal rate delivery (C)</p> Signup and view all the answers

What is the ideal carbohydrate-to-insulin ratio for an infant using an insulin pump?

<p>1 unit per 45 grams of CHO (C)</p> Signup and view all the answers

Which of the following is a complication of diabetic ketoacidosis (DKA)?

<p>Cerebral edema (B)</p> Signup and view all the answers

What is a common sign of cerebral edema in a patient?

<p>Severe headache (A)</p> Signup and view all the answers

What treatment is recommended to manage cerebral edema?

<p>Hyperventilation (A)</p> Signup and view all the answers

What routine is involved in intensive therapy for diabetes?

<p>Monitoring dietary intake and insulin dosing (A)</p> Signup and view all the answers

At what time should blood glucose be monitored at least once a week under intensive therapy?

<p>3 AM (D)</p> Signup and view all the answers

What is a common sign of insulin resistance that can be observed during a physical assessment?

<p>Acanthosis nigricans (A)</p> Signup and view all the answers

What outcome is associated with diabetes that has the lowest reported occurrence?

<p>Blindness (B)</p> Signup and view all the answers

Which statement best describes the cognitive capabilities of adolescents regarding diabetes self-care?

<p>Their desire to fit in may hinder compliance. (A)</p> Signup and view all the answers

What is the recommended treatment for growth hormone deficiency in children?

<p>Biosynthetic growth hormone injections (B)</p> Signup and view all the answers

What should be done if a toddler shows signs of extreme sleepiness or irritability?

<p>Check blood glucose levels (A)</p> Signup and view all the answers

How does regular physical activity affect insulin sensitivity?

<p>It increases insulin sensitivity. (A)</p> Signup and view all the answers

What is the role of medical alert identification for diabetics?

<p>To alert others in case of an emergency. (D)</p> Signup and view all the answers

What is a potential psychological impact of precocious puberty in children?

<p>Social stigmatization (A)</p> Signup and view all the answers

What condition is characterized by the excretion of undigested food in stool that appears increased, frothy, and foul?

<p>Cystic fibrosis (A)</p> Signup and view all the answers

What percentage of individuals with cystic fibrosis are likely to develop liver cirrhosis?

<p>87% (B)</p> Signup and view all the answers

Which of the following is a significant metabolic disorder resulting from excessive water loss in cystic fibrosis patients?

<p>Hyponatremic/hypochloremic alkalosis (C)</p> Signup and view all the answers

What is the most useful diagnostic test for cystic fibrosis?

<p>Sweat Chloride Test (C)</p> Signup and view all the answers

What must be ensured for accurate results in the Sweat Chloride Test?

<p>Stimulation of maximal sweat rate (A)</p> Signup and view all the answers

Which of the following treatments is NOT commonly included for respiratory management in cystic fibrosis patients?

<p>Insulin therapy (B)</p> Signup and view all the answers

What complication can arise in cystic fibrosis patients due to lack of hydration leading to severe constipation?

<p>Rectal prolapse (D)</p> Signup and view all the answers

Which of the following vitamins is not typically given in its water-soluble form to cystic fibrosis patients?

<p>Vitamin A (C)</p> Signup and view all the answers

The treatment of cystic fibrosis often includes which of the following to improve nutritional intake?

<p>Pancreatic enzymes (B)</p> Signup and view all the answers

Delayed puberty in females can be an associated presentation of which health condition?

<p>Cystic fibrosis (D)</p> Signup and view all the answers

What is essential to obtain prior to administering immunizations?

<p>Informed consent from the parents (C)</p> Signup and view all the answers

Which of the following symptoms is NOT commonly associated with erythema infectiosum?

<p>High fever (C)</p> Signup and view all the answers

What is a key characteristic of the measles prodrome?

<p>Presence of Koplik spots (B)</p> Signup and view all the answers

Which statement regarding meningococcal disease is true?

<p>It can lead to blood infections (C)</p> Signup and view all the answers

Which of these options is NOT a recommended practice for vaccine storage?

<p>Store them at room temperature (D)</p> Signup and view all the answers

What is a key way that molluscum contagiosum spreads?

<p>Direct contact with infected objects (A)</p> Signup and view all the answers

What is the appearance of the rash in measles typically characterized by?

<p>Spreading from forehead downward (A)</p> Signup and view all the answers

Which complication is most likely to occur with untreated meningococcal disease?

<p>Death (D)</p> Signup and view all the answers

Flashcards

Meconium ileus

A condition where thickened mucus blocks the intestines, causing blockage and difficulty passing stool. Common in newborns with cystic fibrosis.

Distal intestinal obstruction syndrome

Difficulty digesting and absorbing fats, leading to bulky, foul-smelling stools. Caused by decreased pancreatic enzyme production in cystic fibrosis.

Rectal prolapse

The process of the rectum protruding outside the anus, often caused by chronic constipation. This can occur in CF due to thick mucus blocking stool passage.

Hyponatremic/Hypochloremic alkalosis

A metabolic imbalance where the body loses too much water and electrolytes (sodium, chloride), leading to increased bicarbonate levels, resulting in alkalosis. This can happen in CF due to excessive sweat.

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Hypoalbuminemia

Low levels of albumin, a protein in the blood, which can occur in CF due to malabsorption of nutrients.

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Sweat Chloride Test

A diagnostic test used to measure the chloride concentration in sweat. Elevated chloride levels in sweat are a hallmark of cystic fibrosis.

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Pulmonary Function Test (PFT)

A test used to assess the health and function of the lungs, including lung volume, airflow, and gas exchange capacity.

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Chest Physiotherapy (CPT)

A type of treatment that involves physical techniques to loosen mucus and clear airways. It often includes percussion, vibration, and postural drainage.

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Pancreatic enzymes

Enzymes that help digest food, typically taken by individuals with CF to aid in nutrient absorption.

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Vitamin Supplementation

Supplementation with essential vitamins that are often poorly absorbed in individuals with CF, such as vitamins A, D, E, and K in water-soluble form.

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High Calorie & Protein Diet

A high calorie and protein diet with moderate fat intake, exceeding the recommended daily allowance (RDA) by up to 150%. This type of diet is often used in medical conditions where the body needs extra energy and nutrients.

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CFTR Modulators

Medications used for treating Cystic Fibrosis (CF). These drugs work by enhancing the function of the CFTR protein, which is defective in CF patients.

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CF Carrier Testing

A genetic test offered to couples planning a pregnancy, particularly if one partner is of Caucasian ethnicity, to determine if they are carriers for Cystic Fibrosis (CF).

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Newborn Screening for CF

Mandatory screening for Cystic Fibrosis (CF) conducted on all newborns in the United States. This helps identify infants with CF early, allowing for prompt treatment and improved outcomes.

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Pulmonologist

A healthcare professional who specializes in the treatment of the lungs and respiratory system. They play a crucial role in managing Cystic Fibrosis (CF), a condition that affects the lungs and digestive system.

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Sickle Cell Anemia

A genetic disorder where abnormal hemoglobin, mainly sickle cell hemoglobin (HbS), is overproduced, leading to deformed red blood cells that can cause blockages in small blood vessels.

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Hemoglobin Electrophoresis

A blood test used to identify different types of hemoglobin in the blood. This test can help diagnose Sickle Cell Anemia.

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Sickle Cell Trait

A genetic trait carrying one sickle cell gene (HbS). People with this trait usually don't experience symptoms of sickle cell anemia, but they can pass the gene onto their children.

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Sickle Turbidity Quick Screen Test

A quick screening test performed on newborns to detect sickle cell anemia. It's based on the turbidity (cloudiness) of the blood sample.

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Naloxone (Narcan)

A drug used to treat opioid overdose. It blocks the effects of opioids on the brain, helping to reverse the overdose symptoms.

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Intensive Therapy for Diabetes

An intense diabetes management strategy focusing on frequent blood sugar checks, careful meal planning, and adjusting insulin doses based on carbohydrate intake and exercise.

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Insulin Pump

A method of delivering insulin continuously through a small pump worn on the body, mimicking the body's natural insulin release.

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Diabetic Ketoacidosis (DKA)

A severe complication of uncontrolled diabetes characterized by high blood sugar, ketones in the urine, and dehydration.

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Cerebral Edema in DKA

Swelling in the brain, a serious complication of DKA, often occurring in children.

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Hyperventilation for Cerebral Edema

Increased breathing rate to blow off excess carbon dioxide, a key treatment for cerebral edema.

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Mannitol for Cerebral Edema

A type of medication that helps reduce fluid in the brain, used to treat cerebral edema.

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Decreased Fluid Therapy for Cerebral Edema

Reduced fluid intake to help decrease brain swelling, a part of cerebral edema treatment.

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Head of Bed Elevation for Cerebral Edema

Raising the head of the bed to help reduce pressure in the brain, a part of cerebral edema treatment.

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Acanthosis nigricans

A common sign of insulin resistance, often appearing before type 2 diabetes develops in children. Characterized by thick, dark, and often velvety patches of skin, usually located in folds and creases of the body.

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Growth Hormone Deficiency in Children

Decreased levels of growth hormone due to impaired pituitary gland function, leading to shorter stature in children.

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Precocious Puberty

The onset of secondary sexual characteristics in girls before the age of 8 and boys before the age of 9. Can be problematic due to potential early closure of growth plates, affecting height, and leading to social and emotional challenges.

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Insulin Sensitivity

The body's ability to use insulin effectively is increased. This often happens with regular physical activity.

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Insulin Absorption Rate

The rate at which insulin is absorbed into the bloodstream varies depending on the injection site. The quickest absorption occurs when injected into the abdomen.

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Toddler Sleepiness or Irritability

Severe sleepiness or irritability in toddlers can indicate either low or high blood sugar levels. This requires immediate attention and blood glucose testing.

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Delayed Puberty in Diabetes

Insufficient diabetes management can lead to delayed puberty in children. This highlights the importance of consistent blood sugar control.

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Medical Alert Identification for Diabetics

Individuals with diabetes should always carry medical identification, ensuring emergency personnel are aware of their condition and can provide appropriate help if needed.

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What is Molluscum Contagiosum?

A viral skin infection that causes round, firm, painless bumps. It spreads through contact and usually disappears on its own.

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What is Meningococcal disease?

A rare, serious bacterial infection that can affect the brain, spinal cord, and blood. It can be fatal.

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What is Erythema Infectiosum (Fifth Disease)?

A highly contagious childhood illness characterized by a distinctive facial rash that looks like slapped cheeks.

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What is Measles?

A viral infection that causes a characteristic prodrome (early symptoms) with fever, cough, runny nose, and conjunctivitis. A rash develops later.

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What is Mononucleosis?

A viral infection that can cause sore throat, fever, fatigue, swollen lymph nodes, and other symptoms. It is often associated with swollen tonsils.

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What is the Measles prodrome?

The period before the rash appears in measles, characterized by fever, cough, runny nose, and conjunctivitis.

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What are Koplik spots?

Tiny white spots that appear inside the cheeks during the measles prodrome.

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What is photophobia?

A common symptom of measles that involves sensitivity to light.

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Study Notes

HIRSCHSPRUNG DISEASE

  • Also called congenital aganglionic megacolon
  • Mechanical obstruction from inadequate motility of the intestine
  • Incidence: 1 in 5,000 live births; more common in males and Down syndrome
  • Birth defect; nerve cells missing in intestines, lacking ganglion cells
  • Typically affects the rectum, preventing relaxation and defecation
  • Gold standard: Rectal biopsy showing absence of ganglion cells in the colon
  • Due to the inability to pass stool, the sphincter doesn't relax, causing stool to back up
  • Results in a megacolon (distended sigmoid colon)

PATHOPHYSIOLOGY

  • Aganglionic segment usually includes rectum and proximal colon
  • Accumulation of stool with distention
  • Failure of internal anal sphincter to relax
  • Enterocolitis may occur
  • Ribbon-like stools common

CHILD WITH A COLOSTOMY

  • When lacking ganglion cells, portions of the intestine are removed
  • May be temporary or permanent
  • Temporary: bowel rest for 6 months
  • Permanent: removal of more than 1 foot of intestine
  • Megacolon is treated with resection/colostomy surgery.
  • May need resection repeatedly to treat affected portions

INTUSSUSCEPTION

  • Telescoping or invagination of one part of the intestine into another
  • Usually involves the ileum
  • Cutting off blood supply
  • Occasionally tied to intestinal lesions, sometimes unknown cause
  • Abdominal pain, abdominal mass and blood stools are classic triad
  • Ileum telescopes into itself

MANIFESTATIONS

  • Acute abdominal pain alternating with intervals of no pain
  • Empty RLQ, but all issues within RUQ causing intervals.
  • Passage of red currant jelly stools
  • Sausage-shaped mass in RUQ

CYSTIC FIBROSIS

  • Exocrine gland dysfunction leading to multisystem involvement
  • Most common lethal genetic illness among white children
  • Approximately 1,000 new diagnoses per year in the US

PATHOPHYSIOLOGY

  • In normal cells, chloride channels actively transport chloride to the cell surface, hydrating secretions (e.g., mucus in the lungs).
  • In CF, chloride channels are abnormal in all exocrine glands.
  • Water doesn't follow chloride, making secretions thick and viscous.
  • Increased viscosity of mucus-producing glands
  • Mechanical obstruction, thick secretions, and concretions in glands and ducts lead to problems
  • Primarily affects the respiratory tract and pancreas.

RESPIRATORY MANIFESTATIONS

  • Mucus does not carry inhaled materials out of the lungs.

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