Medicinal Chemistry Unit I: Drug Design & Pharmacokinetics

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Questions and Answers

What is the primary goal of combinatorial synthesis in drug discovery?

  • To design a single drug with multiple receptors
  • To generate a large number of compounds to screen for activity (correct)
  • To create a drug that can cure multiple diseases
  • To develop a specific drug for a particular disease

What is the primary mechanism of action of alkylating agents in cancer chemotherapy?

  • Activation of immune cells
  • Induction of apoptosis
  • Inhibition of DNA replication (correct)
  • Inhibition of protein synthesis

Which of the following pharmacokinetic parameters is used to determine the duration of drug action?

  • Bioavailability
  • Volume of distribution
  • Clearance
  • Half-life (correct)

What is the primary mode of action of direct-acting arteriolar dilators?

<p>Relaxation of smooth muscle in arterioles (B)</p> Signup and view all the answers

What is the primary mechanism of action of sulphonamides?

<p>Inhibition of folic acid synthesis in bacteria (A)</p> Signup and view all the answers

What is the primary goal of receptor site theory approach to drug design?

<p>To design a drug that binds to a specific receptor (C)</p> Signup and view all the answers

What is the primary function of B-lactam ring antibiotics?

<p>Inhibiting cell wall biosynthesis (B)</p> Signup and view all the answers

Which of the following drugs is NOT a CNS depressant?

<p>Antibiotics (B)</p> Signup and view all the answers

What is the name of the process by which Antipsychotic drugs, also known as neuroleptics, were discovered?

<p>Serendipity (D)</p> Signup and view all the answers

Which of the following books is NOT a suggested reading for Medical Chemistry?

<p>The Organic Chemistry of Life, R.B.Silverrman (D)</p> Signup and view all the answers

Which of the following drugs is synthesized from butyrophenones?

<p>Haloperidol (A)</p> Signup and view all the answers

What is the name of the process by which cell walls are formed in bacteria?

<p>Cell wall biosynthesis (A)</p> Signup and view all the answers

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