15 Questions
Which of the following is the zinc-binding moiety of ACE inhibitors?
Dicarboxylate (-COOH) group
What is the mechanism of action of AT2 antagonists?
They mimic the AT2 amino acid sequence
Which class of calcium channel blockers is characterized by aromatic ring substitution?
Diltiazem
Which position of the side-chain of the aryl ring determines the selectivity of beta-blockers?
-Para position
Which of the following beta-blockers has the highest lipid solubility?
Propranolol
Which group of drugs is classified as ACE inhibitors?
1,4 Dihydropyridines
What is the most important structure-function relationship of ACE inhibitors?
Their ability to interact with the zinc component
Which factor contributes to the incomplete absorption of atenolol?
Shorter plasma half-life
Which beta-blocker is the most lipid-soluble and can readily penetrate the blood-brain barrier?
Propanolol
Which factor contributes to the less predictable pharmacokinetics of atenolol during critical illness?
Greater protein binding
Which type of alpha/beta blockers is Prazosin?
Non-selective alpha/beta blockers
Which beta-blocker has the highest tissue penetration?
Propanolol
Which factor is responsible for the higher tissue penetration of propanolol?
Lipid solubility
Which beta-blocker has the shortest plasma half-life?
Atenolol
Which factor contributes to the less predictable pharmacokinetics of atenolol during critical illness?
Greater protein binding
Test your knowledge of the medicinal chemistry of ACE inhibitors and ARBs, focusing on their structure-activity relationships and their interaction with the zinc component of ACE.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
