Medicinal Chemistry Quiz
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Questions and Answers

Which of the following is the zinc-binding moiety of ACE inhibitors?

  • Sulfhydryl (-SH) group
  • Phosphoryl (-PO2) group
  • Carboxylate
  • Dicarboxylate (-COOH) group (correct)

    • What is the mechanism of action of AT2 antagonists?

  • They activate the AT1 receptor
  • They mimic the AT2 amino acid sequence (correct)
  • They bind to the zinc component
  • They inhibit the binding of Angiotensin II

    • Which class of calcium channel blockers is characterized by aromatic ring substitution?

  • Non-dihydropyridines
  • Diltiazem (correct)
  • 1,4 Dihydropyridines
  • Beta-blockers

    • Which position of the side-chain of the aryl ring determines the selectivity of beta-blockers?

    <p>-Para position (C)</p> Signup and view all the answers

    Which of the following beta-blockers has the highest lipid solubility?

    <p>Propranolol (A)</p> Signup and view all the answers

    Which group of drugs is classified as ACE inhibitors?

    <p>1,4 Dihydropyridines (A)</p> Signup and view all the answers

    What is the most important structure-function relationship of ACE inhibitors?

    <p>Their ability to interact with the zinc component (B)</p> Signup and view all the answers

    Which factor contributes to the incomplete absorption of atenolol?

    <p>Shorter plasma half-life (A)</p> Signup and view all the answers

    Which beta-blocker is the most lipid-soluble and can readily penetrate the blood-brain barrier?

    <p>Propanolol (B)</p> Signup and view all the answers

    Which factor contributes to the less predictable pharmacokinetics of atenolol during critical illness?

    <p>Greater protein binding (D)</p> Signup and view all the answers

    Which type of alpha/beta blockers is Prazosin?

    <p>Non-selective alpha/beta blockers (C)</p> Signup and view all the answers

    Which beta-blocker has the highest tissue penetration?

    <p>Propanolol (B)</p> Signup and view all the answers

    Which factor is responsible for the higher tissue penetration of propanolol?

    <p>Lipid solubility (D)</p> Signup and view all the answers

    Which beta-blocker has the shortest plasma half-life?

    <p>Atenolol (A)</p> Signup and view all the answers

    Which factor contributes to the less predictable pharmacokinetics of atenolol during critical illness?

    <p>Greater protein binding (C)</p> Signup and view all the answers

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