Pharm - Osteoporosis

loss

<p>True</p> Signup and view all the answers

<p>Vitamin D</p> Signup and view all the answers

<p>800-1,000</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>5,000 IU daily x 8-12 weeks</p> Signup and view all the answers

<p>Patient with a history of hip / vertebral fracture = YES Patient with a T-score ≤ -2.5 at femoral neck or spine = YES Patient with a Z-score ≤ -2.5 at femoral neck or spine = NO Patient's T score shows osteopenia (-1.0 to -2.5) and FRAX ≥ 3% hip fracture or FRAX ≥ 20% major osteoporosis-related fracture = YES</p> Signup and view all the answers

<p>Hypocalcemia; Esophageal stricture or inability to sit/ stand upright x30mins (PO formulations); eGFR &lt; 30-35</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>Osteonecrosis of the jaw and atypical fractures</p> Signup and view all the answers

<p>moderate-risk patient that is taking PO bisphosphonate = Holiday after 5 years moderate-risk patient using IV bisphosphonate = Holiday after 3 years In high-risk patient that is taking PO bisphosphonate = Holiday after 6-10 years In high-risk patient using IV bisphosphonate = Holiday after 6 years</p> Signup and view all the answers

<p>Renal insufficiency</p> Signup and view all the answers

<p>Dermatologic (rash/dermatitis, eczema)</p> Signup and view all the answers

<p>IV given annually to target mostly spine and hip fracture prevention = Zoledronic acid Tablets given weekly to decrease mostly spine risk of fracture = Risendronate ablets, Effervescent, Solution given weekly to decrease risk of fracture in all risk areas = Alendronate NOT a first line = Ibandronate</p> Signup and view all the answers

<p>PTH analogs (teriparatide and abaloparatide) = Stimulates osteoblasts for anabolic bone building, but only indicated for very high-risk fracture (T-score &lt; -3 or fracture while on tx) Estrogen agonist/antagonist (Envista/raloxifene) = Selectively activates estrogenic pathways in some tissues (e.g., bone) and antagonizes in other tissues; Useful for those with osteoporosis AND history/high risk of breast CA Estrogens = Relief of vasomotor sx associated with menopause and maintenance of BMD post-menopause; Limit to those recently postmenopausal and should be used at lowest effective dose for shortest duration possible Miacalcin(calcitonin) intranasal = Antagonizes effects of parathyroid hormone and Inhibits osteoclast bone resorption; Useful for osteoporotic vertebral fracture pain relief</p> Signup and view all the answers

<p>Evenity(romosozumab)</p> Signup and view all the answers

<p>Good for high risk (hx fx on tx) Reduces fractures = PTH analogs (e.g., Forteo, teriparatide) Good for osteoporosis + breast CA = Estrogren agonist/antagonists (e.g., Evista/raloxefine) Good for recently post-menopausal = Estrogens Good for reducing pain associated with vertebral fractures = Calcitonin</p> Signup and view all the answers

<p>Osteosarcoma Black box warning; Max 2 years lifetime use = PTH analogs (e.g., Forteo, teriparatide) Women only; Caution: Hot flashes, VTE = Estrogren agonist/antagonists (e.g., Evista/raloxefine) Caution: Breast cancer, VTE, stroke = Estrogens Nasal spray (irritating) and no fracture data = Calcitonin</p> Signup and view all the answers

<p>True</p> Signup and view all the answers

<p>Estrogen agonist/antagonist = Inhibits osteoClasts Estrogens = Inhibits osteoClasts Calcitonin = Inhibits osteoClasts PTH analogues = Stimulates osteoBlasts</p> Signup and view all the answers

<p>Acetaminophen</p> Signup and view all the answers

<p>6</p> Signup and view all the answers

<p>1200 mg</p> Signup and view all the answers